Cholesterol-Modified Oligonucleotides as Internal Reaction Controls during DNA-Encoded Chemical Library Synthesis

2021 ◽  
Vol 32 (4) ◽  
pp. 667-671
Author(s):  
Guanyu Yang ◽  
Dou He ◽  
Yijun Zhu ◽  
Weiwei Zhu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Modified Oligonucleotides ◽  
Library Synthesis ◽  
Chemical Library ◽  
Internal Reaction

Microwave-Assisted Solid-Phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis

ChemInform ◽  
2004 ◽  
Vol 35 (7) ◽  
Author(s):  
Fahad Al-Obeidi ◽  
Richard E. Austin ◽  
John F. Okonya ◽  
Daniel R. S. Bond
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Library Synthesis ◽  
Chemical Library ◽  
Phase Synthesis ◽  
Microwave Assisted

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

2021 ◽  
Author(s):  
Jonas Rein ◽  
James R. Annand ◽  
Michael K. Wismer ◽  
Jiantao Fu ◽  
Juno C. Siu ◽  
...  
Keyword(s):  
High Throughput ◽  
Electrochemical Reaction ◽  
Electrochemical Reactor ◽  
Constant Current ◽  
Library Synthesis ◽  
Chemical Library ◽  
Reaction Discovery ◽  
Reaction Optimization ◽  
High Throughput Experimentation ◽  
Broad Array

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community and, especially in industrial settings, has been hindered by the dearth of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HT<i>e<sup>-</sup></i>Chem, a high-throughput microscale electrochemical reactor that is compatible with existing HTE infrastructure, and enables rapid evaluation of a broad array of electrochemical reaction parameters. Utilizing the HT<i>e<sup>-</sup></i>Chem to accelerate reaction optimization, reaction discovery, and chemical library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochemical conditions.

scholarly journals C–N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis

2020 ◽  
Vol 31 (3) ◽  
pp. 770-780 ◽  
Author(s):  
Ying-Chu Chen ◽  
John C. Faver ◽  
Angela F. Ku ◽  
Gabriella Miklossy ◽  
Kevin Riehle ◽  
...  
Keyword(s):  
Library Synthesis ◽  
Chemical Library ◽  
Aryl Bromides

ChemInform Abstract: Polymer-Assisted Solution-Phase Methods for Chemical Library Synthesis

ChemInform ◽  
2001 ◽  
Vol 32 (1) ◽  
pp. no-no
Author(s):  
Daniel L. Fiynn ◽  
Rajesh V. Devraj ◽  
John J. Parlow
Keyword(s):  
Solution Phase ◽  
Library Synthesis ◽  
Chemical Library

ChemInform Abstract: Polymer-Assisted Solution Phase (PASP) Chemical Library Synthesis

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
Daniel L. Flynn ◽  
Rajesh V. Devraj ◽  
Win Naing ◽  
John J. Parlow ◽  
John J. Weidner ◽  
...  
Keyword(s):  
Solution Phase ◽  
Library Synthesis ◽  
Chemical Library

scholarly journals A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis

2019 ◽  
Vol 21 (10) ◽  
pp. 650-655 ◽  
Author(s):  
Anokha S. Ratnayake ◽  
Mark E. Flanagan ◽  
Timothy L. Foley ◽  
Justin D. Smith ◽  
Jillian G. Johnson ◽  
...  
Keyword(s):  
Chemical Reaction ◽  
Solution Phase ◽  
Library Synthesis ◽  
Chemical Library
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