scholarly journals Nanoparticles To Study Lectins in Caenorhabditis elegans: Multivalent Galactose β1-4 Fucose-Functionalized Dendrimers Provide Protection from Oxidative Stress

2021 ◽  
Author(s):  
Harrison W. VanKoten ◽  
Rebecca S. Moore ◽  
Mary J. Cloninger
Chemosphere ◽  
2021 ◽  
Vol 272 ◽  
pp. 129642
Author(s):  
Haibo Chen ◽  
Xin Hua ◽  
Hui Li ◽  
Chen Wang ◽  
Yao Dang ◽  
...  

2021 ◽  
pp. 1-17
Author(s):  
Mani Iyer Prasanth ◽  
James Michael Brimson ◽  
Dicson Sheeja Malar ◽  
Anchalee Prasansuklab ◽  
Tewin Tencomnao

BACKGROUND: Streblus asper Lour., has been reported to have anti-aging and neuroprotective efficacies in vitro. OBJECTIVE: To analyze the anti-aging, anti-photoaging and neuroprotective efficacies of S. asper in Caenorhabditis elegans. METHODS: C. elegans (wild type and gene specific mutants) were treated with S. asper extract and analyzed for lifespan and other health benefits through physiological assays, fluorescence microscopy, qPCR and Western blot. RESULTS: The plant extract was found to increase the lifespan, reduce the accumulation of lipofuscin and modulate the expression of candidate genes. It could extend the lifespan of both daf-16 and daf-2 mutants whereas the pmk-1 mutant showed no effect. The activation of skn-1 was observed in skn-1::GFP transgenic strain and in qPCR expression. Further, the extract can extend the lifespan of UV-A exposed nematodes along with reducing ROS levels. Additionally, the extract also extends lifespan and reduces paralysis in Aβ transgenic strain, apart from reducing Aβ expression. CONCLUSIONS: S. asper was able to extend the lifespan and healthspan of C. elegans which was independent of DAF-16 pathway but dependent on SKN-1 and MAPK which could play a vital role in eliciting the anti-aging, anti-photoaging and neuroprotective effects, as the extract could impart oxidative stress resistance and neuroprotection.


PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82657 ◽  
Author(s):  
I-Ling Tseng ◽  
Ying-Fei Yang ◽  
Chan-Wei Yu ◽  
Wen-Hsuan Li ◽  
Vivian Hsiu-Chuan Liao

2017 ◽  
Vol 20 (1) ◽  
pp. 32-41 ◽  
Author(s):  
Yanxia Xiang ◽  
Ju Zhang ◽  
Haifeng Li ◽  
Qiangqiang Wang ◽  
Lingyun Xiao ◽  
...  

2018 ◽  
Vol 128 ◽  
pp. S125
Author(s):  
Edson Lucas dos Santos ◽  
Natasha Leite ◽  
Laura Costa Alves de Araújo ◽  
José Tarcisio Giffoni de Carvalho ◽  
Kely de Picoli Souza

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Stephen Rigoulot ◽  
Sarah Blondeaux ◽  
Matthew Russo ◽  
Patti T. Erickson

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