scholarly journals Correction to “Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability”

Author(s):  
Md. Shafikur Rahman ◽  
Shikha Kumari ◽  
Shiva Hadi Esfahani ◽  
Saeideh Nozohouri ◽  
Srinidhi Jayaraman ◽  
...  
Keyword(s):  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.


1997 ◽  
Vol 38 (2) ◽  
pp. 268-272 ◽  
Author(s):  
F. Luzzani ◽  
P. Cipolla ◽  
M. L. Pelaprat ◽  
F. Robert ◽  
C. Gotti ◽  
...  

1991 ◽  
Vol 56 (11) ◽  
pp. 2448-2455 ◽  
Author(s):  
C. Robin Ganellin ◽  
Dalia Jayes ◽  
Yasmin S. Khalaf ◽  
Wasyl Tertiuk ◽  
Jean-Michel Arrang ◽  
...  

The synthesis and evaluation as H3-receptor histamine antagonists is described of novel isoteric analogues of thioperamide. The compounds are designed to have fewer NH groups in order to assist brain penetration. However none of the compounds is sufficiently active as an antagonist in vitro. The 2-pyridyl analogue II has Ki = 13 μmol 1-1.


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