Hybridization of Poly(oxazoline) and Poly(ethylene oxide)-Based Amphiphilic Copolymers into Thermosensitive Mixed Micelles of Tunable Cloud Point

Langmuir ◽  
2021 ◽  
Author(s):  
Alice Gontier ◽  
Frédéric Renou ◽  
Olivier Colombani ◽  
Fabrice Burel ◽  
Gaëlle Morandi
2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Gregory J. Zilinskas ◽  
Abdolrasoul Soleimani ◽  
Elizabeth R. Gillies

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.


2020 ◽  
Vol 69 (5) ◽  
pp. 449-453
Author(s):  
Tasuku Horiuchi ◽  
Kazuaki Rikiyama ◽  
Kenji Sakanaya ◽  
Yusuke Sanada ◽  
Keisuke Watanabe ◽  
...  

2017 ◽  
Vol 134 (44) ◽  
pp. 45492 ◽  
Author(s):  
Irene D. Grozdova ◽  
Gennadiy A. Badun ◽  
Maria G. Chernysheva ◽  
Victor N. Orlov ◽  
Andrey V. Romanyuk ◽  
...  

Langmuir ◽  
2009 ◽  
Vol 25 (1) ◽  
pp. 515-521 ◽  
Author(s):  
Frédéric Renou ◽  
Taco Nicolai ◽  
Erwan Nicol ◽  
Lazhar Benyahia

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