Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

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Design of dual stimuli responsive polymer modified magnetic nanoparticles for targeted anti-cancer drug delivery and enhanced MR imaging

New Journal of Chemistry ◽

10.1039/c5nj02504d ◽

2016 ◽

Vol 40 (1) ◽

pp. 545-557 ◽

Cited By ~ 33

Author(s):

Dipsikha Bhattacharya ◽

Birendra Behera ◽

Sumanta Kumar Sahu ◽

Rajakumar Ananthakrishnan ◽

Tapas Kumar Maiti ◽

...

Keyword(s):

Cancer Drug ◽

Acidic Ph ◽

Stimuli Responsive ◽

Triggered Release ◽

Dual Responsive ◽

Anti Cancer ◽

Responsive Polymer ◽

Modified Magnetic Nanoparticles ◽

Cancer Drug Delivery ◽

Stimuli Responsive Polymer

Stimuli triggered release of DOX from dual responsive theranostic nanocarriers mimicking lysosomal conditions i.e. physiological temperature (37 °C) and acidic pH (5.5).

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An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

Nanoscale ◽

10.1039/c8nr05061a ◽

2018 ◽

Vol 10 (43) ◽

pp. 20126-20130 ◽

Cited By ~ 9

Author(s):

Anna Wang ◽

Ling Yin ◽

Lei He ◽

Huawei Xia ◽

Fei Chen ◽

...

Keyword(s):

Tumour Microenvironment ◽

Ct Imaging ◽

Nanoparticle Assembly ◽

Acidic Ph ◽

Stimuli Responsive ◽

Enhanced Ct ◽

Ph Reduction

A smart acidic pH/glutathione (GSH) dual-stimuli responsive nanoprobe (1) was designed and synthesized herein. This probe could undergo intermolecular CBT condensation to form nanoparticle assembly in tumour microenvironment, resulting in enhanced tumour CT imaging.

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Design and Engineering of Hypoxia and Acidic pH Dual‐Stimuli‐Responsive Intelligent Fluorescent Nanoprobe for Precise Tumor Imaging

Small ◽

10.1002/smll.202100243 ◽

2021 ◽

pp. 2100243

Author(s):

Shiya Chen ◽

Mingjian Chen ◽

Jinfeng Yang ◽

Xianqing Zeng ◽

Yibo Zhou ◽

...

Keyword(s):

Tumor Imaging ◽

Acidic Ph ◽

Stimuli Responsive ◽

Fluorescent Nanoprobe

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Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine

Nanotechnology Reviews ◽

10.1515/ntrev-2021-0067 ◽

2021 ◽

Vol 10 (1) ◽

pp. 933-953

Author(s):

Baranya Murugan ◽

Suresh Sagadevan ◽

Is Fatimah ◽

Won-Chun Oh ◽

Mohd Abd Motalib Hossain ◽

...

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Controlled Release ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Release Profile ◽

Acidic Ph ◽

Stimuli Responsive ◽

External Stimuli

Abstract Nanomedicine is ongoing current research in the applications of nanotechnology for cancer therapy. Simply from a technology perspective, this field of research has an enormous broadening and success to date. Recently, nanomedicine has also made inroads in the treatment of cancer. Stimuli-responsive nanoparticles are an emerging field of research because its targeting capacity is of great interest in the treatment of cancer. The responsive nanoparticles are efficient in encountering different internal biological stimuli (acidic, pH, redox, and enzyme) and external stimuli (temperature, ultrasounds, magnetic field, and light), which are used as smart nanocarriers for delivery of the chemotherapeutic and imaging agents for cancer therapy. In-depth, the responsive nanocarrier that responds to the biological cues is of pronounced interest due to its capability to provide a controlled release profile at the tumor-specific site. The outlook of this review focuses on the stimuli-responsive nanocarrier drug delivery systems in sequence to address the biological challenges that need to be evaluated to overcome conventional cancer therapy.

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Amino-functional polyethers: versatile, stimuli-responsive polymers

Polymer Chemistry ◽

10.1039/d0py00466a ◽

2020 ◽

Vol 11 (24) ◽

pp. 3940-3950 ◽

Cited By ~ 2

Author(s):

Patrick Verkoyen ◽

Holger Frey

Keyword(s):

Ring Opening ◽

Review Article ◽

Stimuli Responsive ◽

New Class ◽

Stimuli Responsive Polymers ◽

Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

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4D printing technology, modern era: A short review

International Journal of Energy Technology ◽

10.32438//ijet.203015 ◽

2020 ◽

pp. 92-111

Author(s):

Khodadad Mostakim ◽

Nahid Imtiaz Masuk ◽

Md. Rakib Hasan ◽

Md. Shafikul Islam

Keyword(s):

Smart Materials ◽

Computer Aided Design ◽

Short Review ◽

Stimuli Responsive ◽

4D Printing ◽

Space Applications ◽

Printing Technology ◽

Practical Applications ◽

Biomedical Technologies ◽

Novel Material

The advancement in 3D printing has led to the rapid growth of 4D printing technology. Adding time, as the fourth dimension, this technology ushered the potential of a massive evolution in fields of biomedical technologies, space applications, deployable structures, manufacturing industries, and so forth. This technology performs ingenious design, using smart materials to create advanced forms of the 3-D printed specimen. Improvements in Computer-aided design, additive manufacturing process, and material science engineering have ultimately favored the growth of 4-D printing innovation and revealed an effective method to gather complex 3-D structures. Contrast to all these developments, novel material is still a challenging sector. However, this short review illustrates the basic of 4D printing, summarizes the stimuli responsive materials properties, which have prominent role in the field of 4D technology. In addition, the practical applications are depicted and the potential prospect of this technology is put forward.

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Synthesis of Smart Mesoporous Materials

MRS Proceedings ◽

10.1557/proc-775-p7.8 ◽

2003 ◽

Vol 775 ◽

Author(s):

G.V.Rama Rao ◽

Qiang Fu ◽

Linnea K. Ista ◽

Huifang Xu ◽

S. Balamurugan ◽

...

Keyword(s):

Mesoporous Silica ◽

Mesoporous Materials ◽

Fluorescent Dyes ◽

Thermo Gravimetric Analysis ◽

Molecular Transport ◽

Solute Diffusion ◽

Gravimetric Analysis ◽

Stimuli Responsive ◽

Porous Network ◽

Hybrid Mesoporous Materials

AbstractThis study details development of hybrid mesoporous materials in which molecular transport through mesopores can be precisely controlled and reversibly modulated. Mesoporous silica materials formed by surfactant templating were modified by surface initiated atom transfer radical polymerization of poly(N-isopropyl acrylamide) (PNIPAAm) a stimuli responsive polymer (SRP) within the porous network. Thermo gravimetric analysis and FTIR spectroscopy were used to confirm the presence of PNIPAAm on the silica surface. Nitrogen porosimetry, transmission electron microscopy and X-ray diffraction analyses confirmed that polymerization occurred uniformly within the porous network. Uptake and release of fluorescent dyes from the particles was monitored by spectrofluorimetry and scanning laser confocal microscopy. Results suggest that the presence of PNIPAAm, a SRP, in the porous network can be used to modulate the transport of aqueous solutes. At low temperature, (e.g., room temperature) the PNIPAAm is hydrated and extended and inhibits transport of analytes; at higher temperatures (e.g., 50°C) it is hydrophobic and is collapsed within the pore network, thus allowing solute diffusion into or out of the mesoporous silica. The transition form hydrophilic to hydrophobic state on polymer grafted mesoporous membranes was determined by contact angle measurements. This work has implications for the development of materials for the selective control of transport of molecular solutes in a variety of applications.

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Smart Polymers and their Applications: A Review

International Journal of Current Pharmaceutical Review and Research ◽

10.25258/ijcprr.v8i03.9220 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Gore S. A. ◽

Gholve S. B. ◽

Savalsure S. M. ◽

Ghodake K. B. ◽

Bhusnure O. G. ◽

...

Keyword(s):

Oil Recovery ◽

Water Soluble ◽

Solution Temperature ◽

Smart Polymers ◽

Stimuli Responsive ◽

Responsive Materials ◽

Water Soluble Polymers ◽

Commercial Applications ◽

Stimuli Sensitive ◽

External Stimuli

Smart polymers are materials that respond to small external stimuli. These are also referred as stimuli responsive materials or intelligent materials. Smart polymers that can exhibit stimuli-sensitive properties are becoming important in many commercial applications. These polymers can change shape, strength and pore size based on external factors such as temperature, pH and stress. The stimuli include salt, UV irradiation, temperature, pH, magnetic or electric field, ionic factors etc. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications. Water soluble polymers with tunable lower critical solution temperature (LCST) are of increasing interest for biological applications such as cell patterning, smart drug release, DNA sequencing etc.

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Revisiting the High-Pressure Properties of the Metal-Organic Frameworks ZIF-8 and ZIF-67

10.26434/chemrxiv.13146278.v1 ◽

2020 ◽

Author(s):

Pia Vervoorts ◽

Stefan Burger ◽

Karina Hemmer ◽

Gregor Kieslich

Keyword(s):

High Pressure ◽

State Of The Art ◽

Energy Landscape ◽

Structural Flexibility ◽

Zeolitic Imidazolate Frameworks ◽

Stimuli Responsive ◽

X Ray Diffraction ◽

X Ray ◽

Open Questions ◽

Metal Organic

The zeolitic imidazolate frameworks ZIF-8 and ZIF-67 harbour a series of fascinating stimuli responsive properties. Looking at their responsitivity to hydrostatic pressure as stimulus, open questions exist regarding the isotropic compression with non-penetrating pressure transmitting media. By applying a state-of-the-art high-pressure powder X-ray diffraction setup, we revisit the high-pressure behaviour of ZIF-8 and ZIF-67 up to p = 0.4 GPa in small pressure increments. We observe a drastic, reversible change of high-pressure powder X-ray diffraction data at p = 0.3 GPa, discovering large volume structural flexibility in ZIF-8 and ZIF-67. Our results imply a shallow underlying energy landscape in ZIF-8 and ZIF-67, an observation that might point at rich polymorphism of ZIF-8 and ZIF-67, similar to ZIF-4(Zn).

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