Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation

Author(s):  
Zhiwei Chen ◽  
Nastaran Salehi Marzijarani ◽  
Scott Quirie ◽  
Gregory F. Pirrone ◽  
Stephen M. Dalby ◽  
...  
Author(s):  
Bahadır Tunaboylu ◽  
Biset Toprak ◽  
Ahmet Korhan Binark ◽  
Osman Öztürk ◽  
Selim Zaim

Author(s):  
David E. Lee ◽  
H. Thomas Hahn

Abstract In order to address the computational costs of modeling and analyzing manufacturing processes, a novel approach to virtual manufacturing process engineering using generic modular operations is presented. Relying on a state based representation of operation control for a simplified virtual manufacturing workcell, the valid states for each sequence of generic modular operations are aggregated and both operation state and processing constraints applied to specify the subtasks required to complete each step in a product’s process plan. By adopting this state based control approach, virtual process engineering provides a direct mechanism to map virtual process representations onto actualized processes. Using these generic modular operations and their temporal and processing dependencies, the computationally complex elements of virtual manufacturing process simulation can be directly identified and an architecture for virtual process development specified. Examples from both machining and assembly processes are provided.


2009 ◽  
Author(s):  
Dirk Ortloff ◽  
Kai Hahn ◽  
Jens Popp ◽  
Thilo Schmidt ◽  
Rainer Brück

2016 ◽  
Vol 18 (24) ◽  
pp. 6564-6572 ◽  
Author(s):  
Valerio Isoni ◽  
Loretta L. Wong ◽  
Hsien H. Khoo ◽  
Iskandar Halim ◽  
Paul Sharratt

A practicable, LCA based methodology has been developed to evaluate the sustainability implications of solvent selection during early process development for a batch manufacturing process for an API.


2005 ◽  
Vol 9 (6) ◽  
pp. 1003-1008 ◽  
Author(s):  
Flavio Chavez Lopez ◽  
Ashish Shankar ◽  
Maethonia Thompson ◽  
Brandon Shealy ◽  
Dobbert Locklear ◽  
...  

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