Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

2021 ◽  
Author(s):  
Cecilia Bottecchia ◽  
François Lévesque ◽  
Jonathan P. McMullen ◽  
Yining Ji ◽  
Mikhail Reibarkh ◽  
...  
Keyword(s):  
Visible Light ◽  
Manufacturing Process ◽  
Continuous Flow ◽  
Process Development

Visible Light-Mediated Oxidative Debenzylation

2020 ◽  
Author(s):  
Cristian Cavedon ◽  
Eric T. Sletten ◽  
Amiera Madani ◽  
Olaf Niemeyer ◽  
Peter H. Seeberger ◽  
...  
Keyword(s):  
Reaction Time ◽  
Visible Light ◽  
Functional Groups ◽  
Continuous Flow ◽  
Protecting Groups ◽  
Benzyl Ether ◽  
Complex Molecules ◽  
Protective Groups ◽  
Benzyl Ethers ◽  
Harsh Conditions

Protecting groups are key in the synthesis of complex molecules such as carbohydrates to distinguish functional groups of similar reactivity. The harsh conditions required to cleave stable benzyl ether protective groups are not compatible with many other protective and functional groups. The mild, visible light-mediated debenzylation disclosed here renders benzyl ethers orthogonal protective groups. Key to success is the use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as stoichiometric or catalytic photooxidant such that benzyl ethers can be cleaved in the presence of azides, alkenes, and alkynes. The reaction time for this transformation can be reduced from hours to minutes in continuous flow. <br>

Visible light-induced iniferter polymerization of methacrylates enhanced by continuous flow

2017 ◽  
Vol 8 (42) ◽  
pp. 6496-6505 ◽  
Author(s):  
Maarten Rubens ◽  
Phanumat Latsrisaeng ◽  
Tanja Junkers
Keyword(s):  
Block Copolymers ◽  
Visible Light ◽  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Visible-light induced photoiniferter polymerization in continuous flow reactors is very efficient in yielding low dispersity methacrylate block copolymers.

Manufacturing Process Development for Thin Film Filaments as a New Product

2020 ◽  
pp. 513-522
Author(s):  
Bahadır Tunaboylu ◽  
Biset Toprak ◽  
Ahmet Korhan Binark ◽  
Osman Öztürk ◽  
Selim Zaim
Keyword(s):  
Thin Film ◽  
Manufacturing Process ◽  
Process Development ◽  
New Product

scholarly journals Photonic contacting of gas–liquid phases in a falling film microreactor for continuous-flow photochemical catalysis with visible light

2016 ◽  
Vol 1 (6) ◽  
pp. 636-648 ◽  
Author(s):  
Thomas H. Rehm ◽  
Sylvain Gros ◽  
Patrick Löb ◽  
Albert Renken
Keyword(s):  
Visible Light ◽  
Process Evaluation ◽  
Continuous Flow ◽  
Falling Film ◽  
Dye Sensitized ◽  
Photochemical Conversion ◽  
Liquid Phases ◽  
Film Reactor ◽  
Photochemical Catalysis

A microstructured falling film reactor was applied to the dye-sensitized photochemical conversion of 1,5-dihydroxynaphthalene to juglone for reactor and process evaluation.

Generic Modular Operations for Virtual Manufacturing Process Engineering

1997 ◽  
Author(s):  
David E. Lee ◽  
H. Thomas Hahn
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Process Engineering ◽  
Virtual Manufacturing ◽  
Control Approach ◽  
Computational Costs ◽  
Direct Mechanism ◽  
Novel Approach ◽  
Operation Control ◽  
Virtual Process

Abstract In order to address the computational costs of modeling and analyzing manufacturing processes, a novel approach to virtual manufacturing process engineering using generic modular operations is presented. Relying on a state based representation of operation control for a simplified virtual manufacturing workcell, the valid states for each sequence of generic modular operations are aggregated and both operation state and processing constraints applied to specify the subtasks required to complete each step in a product’s process plan. By adopting this state based control approach, virtual process engineering provides a direct mechanism to map virtual process representations onto actualized processes. Using these generic modular operations and their temporal and processing dependencies, the computationally complex elements of virtual manufacturing process simulation can be directly identified and an architecture for virtual process development specified. Examples from both machining and assembly processes are provided.

scholarly journals Metal-Free Visible-Light-Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow

2019 ◽  
Vol 2020 (10) ◽  
pp. 1429-1432 ◽  
Author(s):  
Anne-Laure Barthelemy ◽  
Guillaume Dagousset ◽  
Emmanuel Magnier
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Metal Free
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