Asymmetric Synthesis of N–N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

2021 ◽  
Author(s):  
Ming Pan ◽  
Ying-Bo Shao ◽  
Qun Zhao ◽  
Xin Li
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer ◽  
Chiral Compounds ◽  
Axially Chiral

scholarly journals Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides

2017 ◽  
Vol 13 ◽  
pp. 1518-1523 ◽  
Author(s):  
Ryota Miyaji ◽  
Yuuki Wada ◽  
Akira Matsumoto ◽  
Keisuke Asano ◽  
Seijiro Matsubara
Keyword(s):  
Asymmetric Synthesis ◽  
Functional Groups ◽  
Enantioselective Synthesis ◽  
Chiral Compounds ◽  
Axially Chiral ◽  
Electrophilic Bromination ◽  
Mechanistic Investigations ◽  
Molecular Skeleton

Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination. The results demonstrate the versatility of bifunctional organocatalysts for the enantioselective construction of axially chiral compounds. Moderate to good enantioselectivities were afforded with a range of benzamide substrates. Mechanistic investigations were also carried out.

Phase-Transfer-Catalyzed Asymmetric Synthesis of Axially Chiral Anilides

2013 ◽  
Vol 8 (12) ◽  
pp. 3214-3221 ◽  
Author(s):  
Kun Liu ◽  
Xiangfei Wu ◽  
S. B. Jennifer Kan ◽  
Seiji Shirakawa ◽  
Keiji Maruoka
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer ◽  
Axially Chiral

scholarly journals Asymmetric Synthesis of N-N Axially Chiral Compounds via Organocatalytic Atroposelective N-Acylation

2021 ◽  
Author(s):  
Wei Lin ◽  
Qun Zhao ◽  
Yao Li ◽  
Ming Pan ◽  
Chen Yang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Acylation Reaction ◽  
Axial Chirality ◽  
Chiral Compounds ◽  
Axially Chiral

Compared with the well-developed C-C and C-N axial chirality, asymmetric synthesis of N-N axial chirality remains elusive and challenging. Herein we report the first atroposelective N-acylation reaction of quinazolinone type benzamides...

ChemInform Abstract: Phase-Transfer-Catalyzed Asymmetric Synthesis of Axially Chiral Anilides.

ChemInform ◽  
2014 ◽  
Vol 45 (19) ◽  
pp. no-no
Author(s):  
Kun Liu ◽  
Xiangfei Wu ◽  
S. B. Jennifer Kan ◽  
Seiji Shirakawa ◽  
Keiji Maruoka
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer ◽  
Axially Chiral

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert
Keyword(s):  
Chiral Compounds ◽  
The Past ◽  
Recent Advances ◽  
New Concepts ◽  
Axially Chiral ◽  
Recent Developments ◽  
Synthetic Routes

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.

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