Ureasil–Polyether–CoFe2O4 Nanocomposites: Coupling a Drug Delivery System and Magnetic Hyperthermia

Author(s):  
Willian Max O. S. de Santana ◽  
Sébastien Abramson ◽  
Rodolfo Fini ◽  
Bruno L. Caetano ◽  
Christine Ménager ◽  
...  
Nanoscale ◽  
2021 ◽  
Author(s):  
Shuangyu Liu ◽  
Dongsheng Shi ◽  
Ling Chen ◽  
Yu Yan ◽  
Xingqi Wang ◽  
...  

Combination of chemotherapy and targeted magnetic hyperthermia (TMH) via designed magnetic nanocrystals (MNCs) drug delivery system was considered as an effective tumor synergistic therapy strategy. In this paper, we successfully...


Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi

Drug Research ◽  
2013 ◽  
Vol 63 (04) ◽  
pp. 203-209 ◽  
Author(s):  
G.-H. Choo ◽  
S.-J. Park ◽  
S.-J. Hwang ◽  
M.-S. Kim

2014 ◽  
Vol 9 (9) ◽  
pp. 561-565 ◽  
Author(s):  
Liu Guoqing ◽  
Zhou Huafeng ◽  
Zhang Jing ◽  
Yan Zemin ◽  
Duan Mingxing ◽  
...  

2004 ◽  
Vol 68A (3) ◽  
pp. 489-495 ◽  
Author(s):  
Deenu Kanjickal ◽  
Stephanie Lopina ◽  
M. Michelle Evancho-Chapman ◽  
Steven Schmidt ◽  
Duane Donovan ◽  
...  

2018 ◽  
Vol 11 (8) ◽  
pp. e201700401 ◽  
Author(s):  
Honoka Fujii ◽  
Sachiko Horie ◽  
Kazu Takeda ◽  
Shiro Mori ◽  
Tetsuya Kodama

Drug Research ◽  
2013 ◽  
Vol 63 (10) ◽  
pp. 501-509 ◽  
Author(s):  
Y. Xie ◽  
Y. Hu ◽  
M. Shen ◽  
Y. Ma ◽  
J. Zhong ◽  
...  

Planta Medica ◽  
2020 ◽  
Author(s):  
Patcharawalai Jaisamut ◽  
Subhaphorn Wanna ◽  
Surasak Limsuwan ◽  
Sasitorn Chusri ◽  
Kamonthip Wiwattanawongsa ◽  
...  

AbstractBoth quercetin and resveratrol are promising plant-derived compounds with various well-described biological activities; however, they are categorized as having low aqueous solubility and labile natural compounds. The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol. The suitable self-microemulsifying formulation containing quercetin together with resveratrol comprised 100 mg Capryol 90, 700 mg Cremophor EL, 200 mg Labrasol, 20 mg quercetin, and 20 mg resveratrol, which gave a particle size of 16.91 ± 0.08 nm and was stable under both intermediate and accelerated storage conditions for 12 months. The percentages of release for quercetin and resveratrol in the self-microemulsifying formulation were 75.88 ± 1.44 and 86.32 ± 2.32%, respectively, at 30 min. In rats, an in vivo pharmacokinetics study revealed that the area under the curve of the self-microemulsifying formulation containing quercetin and resveratrol increased approximately ninefold for quercetin and threefold for resveratrol compared with the unformulated compounds. Moreover, the self-microemulsifying formulation containing quercetin and resveratrol slightly enhanced the in vitro antioxidant and cytotoxic effects on AGS, Caco-2, and HT-29 cells. These findings demonstrate that the self-microemulsifying formulation containing quercetin and resveratrol could successfully enhance the oral bioavailability of the combination of quercetin and resveratrol without interfering with their biological activities. These results provide valuable information for more in-depth research into the utilization of combined quercetin and resveratrol.


2016 ◽  
Vol 06 (01) ◽  
pp. 074-079
Author(s):  
Amitha Ramesh ◽  
Agumbe Priyanka Prakash ◽  
Biju Thomas

AbstractPeriodontitis is an immuno-inflammatory disease of the tissues surrounding the teeth. Various treatment modalities like mechanical debridement and use of antimicrobials have been followed in the treatment of such conditions. Introduction of local drug delivery system in the periodontal pocket is a promising therapeutic modality for achieving better clinical outcomes when used as an adjunct to conventional non surgical periodontal therapy. Intensive research efforts are now focussed on the development of new strategies for more effective treatment.


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