scholarly journals Elucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate Reductase

Biochemistry ◽  
2013 ◽  
Vol 52 (41) ◽  
pp. 7318-7326 ◽  
Author(s):  
Kristen M. Lamb ◽  
Narendran G-Dayanandan ◽  
Dennis L. Wright ◽  
Amy C. Anderson
Keyword(s):  
Crystal Structures ◽  
Dihydrofolate Reductase ◽  
Human Dihydrofolate Reductase

Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Biochemistry ◽  
1990 ◽  
Vol 29 (40) ◽  
pp. 9467-9479 ◽  
Author(s):  
Jay F. Davies ◽  
Tavner J. Delcamp ◽  
Neal J. Prendergast ◽  
Victor A. Ashford ◽  
James H. Freisheim ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Dihydrofolate Reductase ◽  
Human Dihydrofolate Reductase

Electronic properties investigation of human dihydrofolate reductase complexes with ligands

2020 ◽  
pp. 1-16
Author(s):  
Vladislav Naumovich ◽  
Maria Grishina ◽  
Jurica Novak ◽  
Prateek Pathak ◽  
Vladimir Potemkin ◽  
...  
Keyword(s):  
Electronic Properties ◽  
Dihydrofolate Reductase ◽  
Human Dihydrofolate Reductase

scholarly journals Assignment of the human dihydrofolate reductase gene to the q11----q22 region of chromosome 5.

1984 ◽  
Vol 4 (10) ◽  
pp. 2010-2016 ◽  
Author(s):  
V L Funanage ◽  
T T Myoda ◽  
P A Moses ◽  
H R Cowell
Keyword(s):  
Dihydrofolate Reductase ◽  
Hybrid Cell ◽  
Chinese Hamster ◽  
Ovary Cell ◽  
Chromosome 5 ◽  
Dhfr Gene ◽  
Reductase Gene ◽  
Ovary Cell Line ◽  
Biochemical Analyses ◽  
Human Dihydrofolate Reductase

Cells from a dihydrofolate reductase-deficient Chinese hamster ovary cell line were hybridized to human fetal skin fibroblast cells. Nineteen dihydrofolate reductase-positive hybrid clones were isolated and characterized. Cytogenetic and biochemical analyses of these clones have shown that the human dihydrofolate reductase (DHFR) gene is located on chromosome 5. Three of these hybrid cell lines contained different terminal deletions of chromosome 5. An analysis of the breakpoints of these deletions has demonstrated that the DHFR gene resides in the q11----q22 region.

scholarly journals A DFT-based QSAR study on inhibition of human dihydrofolate reductase

2016 ◽  
Vol 70 ◽  
pp. 23-29 ◽  
Author(s):  
Sedat Karabulut ◽  
Natalia Sizochenko ◽  
Adnan Orhan ◽  
Jerzy Leszczynski
Keyword(s):  
Dihydrofolate Reductase ◽  
Qsar Study ◽  
Human Dihydrofolate Reductase
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