Synthesis and Iron Sequestration Equilibria of Novel Exocyclic 3-Hydroxy-2-pyridinone Donor Group Siderophore Mimics

We have designed and synthesized a new chromophore having a 1,1,7,7-tetramethyljulolidine fused furan ring as the electron donor group to systematically investigate the role of the benzo[b]furan ring in NLO chromophores.

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Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison

Blood ◽

10.1182/blood-2008-07-168625 ◽

2009 ◽

Vol 113 (6) ◽

pp. 1375-1382 ◽

Cited By ~ 111

Author(s):

Jan J. Cornelissen ◽

Bronno van der Holt ◽

Gregor E. G. Verhoef ◽

Mars B. van 't Veer ◽

Marinus H. J. van Oers ◽

...

Keyword(s):

Stem Cell ◽

Acute Lymphoblastic Leukemia ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Lymphoblastic Leukemia ◽

Adult Patients ◽

Donor Group ◽

No Donor ◽

Sibling Donor ◽

Standard Risk

Abstract While commonly accepted in poor-risk acute lymphoblastic leukemia (ALL), the role of allogeneic hematopoietic stem cell transplantation (allo-SCT) is still disputed in adult patients with standard-risk ALL. We evaluated outcome of patients with ALL in first complete remission (CR1), according to a sibling donor versus no-donor comparison. Eligible patients (433) were entered in 2 consecutive, prospective studies, of whom 288 (67%) were younger than 55 years, in CR1, and eligible to receive consolidation by either an autologous SCT or an allo-SCT. Allo-SCT was performed in 91 of 96 patients with a compatible sibling donor. Cumulative incidences of relapse at 5 years were, respectively, 24 and 55% for patients with a donor versus those without a donor (hazard ratio [HR], 0.37; 0.23-0.60; P < .001). Nonrelapse mortality estimated 16% (± 4) at 5 years after allo-SCT. As a result, disease-free survival (DFS) at 5 years was significantly better in the donor group: 60 versus 42% in the no-donor group (HR: 0.60; 0.41-0.89; P = .01). After risk-group analysis, improved outcome was more pronounced in standard-risk patients with a donor, who experienced an overall survival of 69% at 5 years (P = .05). In conclusion, standard-risk ALL patients with a sibling donor may show favorable survival following SCT, due to both a strong reduction of relapse and a modest nonrelapse mortality. This trial is registered with http://www.trialregister.nl under trial ID NTR228.

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Synthesis and characterization of novel second-order NLO-chromophores bearing pyrrole as an electron donor group

Tetrahedron ◽

10.1016/j.tet.2012.07.082 ◽

2012 ◽

Vol 68 (39) ◽

pp. 8147-8155 ◽

Cited By ~ 26

Author(s):

M. Cidália R. Castro ◽

M. Belsley ◽

A. Maurício C. Fonseca ◽

M. Manuela M. Raposo

Keyword(s):

Electron Donor ◽

Second Order ◽

Synthesis And Characterization ◽

Donor Group ◽

Nlo Chromophores

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The Importance of Anaemia in Cerebral and Uncomplicated Falciparum Malaria: Role of Complications, Dyserythropoiesis and Iron Sequestration

QJM ◽

10.1093/oxfordjournals.qjmed.a067960 ◽

1986 ◽

Cited By ~ 1

Keyword(s):

Falciparum Malaria ◽

Uncomplicated Falciparum Malaria ◽

Iron Sequestration

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Synthesis and structure of push–pull merocyanines based on barbituric and thiobarbituric acid

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989019011071 ◽

2019 ◽

Vol 75 (9) ◽

pp. 1306-1310

Author(s):

Georgii Bogdanov ◽

John P. Tillotson ◽

Jenna Bustos ◽

Tatiana V. Timofeeva

Keyword(s):

Indole Derivative ◽

Thiobarbituric Acid ◽

Donor Group

Two compounds, 1,3-diethyl-5-{(2E,4E)-6-[(E)-1,3,3-trimethylindolin-2-ylidene]hexa-2,4-dien-1-ylidene}pyrimidine-2,4,6(1H,3H,5H)-trione or TMI, C25H29N3O3, and 1,3-diethyl-2-sulfanylidene-5-[2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]dihydropyrimidine-4,6(1H,5H)-dione or DTB, C21H25N3O2S, have been crystallized and studied. These compounds contain the same indole derivative donor group and differ in their acceptor groups (in TMI it contains oxygen in the para position, and in DTB sulfur) and the length of the π-bridge. In both materials, molecules are packed in a herringbone manner with differences in the twist and fold angles. In both structures, the molecules are connected by weak C—H...O and/or C—H...S bonds.

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Crystal structures of three 3,4,5-trimethoxybenzamide-based derivatives

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989016005958 ◽

2016 ◽

Vol 72 (5) ◽

pp. 675-682 ◽

Cited By ~ 1

Author(s):

Ligia R. Gomes ◽

John Nicolson Low ◽

Catarina Oliveira ◽

Fernando Cagide ◽

Fernanda Borges

Keyword(s):

Hydrogen Bond ◽

Hydrogen Bonding ◽

Crystal Structures ◽

Methoxy Group ◽

Combined Effect ◽

Donor Group ◽

Methoxy Substituent ◽

A Chain ◽

Benzamide Derivatives

The crystal structures of three benzamide derivatives,viz. N-(6-hydroxyhexyl)-3,4,5-trimethoxybenzamide, C16H25NO5, (1),N-(6-anilinohexyl)-3,4,5-trimethoxybenzamide, C22H30N2O4, (2), andN-(6,6-diethoxyhexyl)-3,4,5-trimethoxybenzamide, C20H33NO6, (3), are described. These compounds differ only in the substituent at the end of the hexyl chain and the nature of these substituents determines the differences in hydrogen bonding between the molecules. In each molecule, them-methoxy substituents are virtually coplanar with the benzyl ring, while thep-methoxy substituent is almost perpendicular. The carbonyl O atom of the amide rotamer istransrelated with the amidic H atom. In each structure, the benzamide N—H donor group and O acceptor atoms link the molecules intoC(4) chains. In1, a terminal –OH group links the molecules into aC(3) chain and the combined effect of theC(4) andC(3) chains is a ribbon made up of screw relatedR22(17) rings in which the ...O—H... chain lies in the centre of the ribbon and the trimethoxybenzyl groups forms the edges. In2, the combination of the benzamideC(4) chain and the hydrogen bond formed by the terminal N—H group to an O atom of the 4-methoxy group link the molecules into a chain ofR22(17) rings. In3, the molecules are linked only byC(4) chains.

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Comparison of molecular structures of cis-bis[8-(dimethylphosphanyl)quinoline]nickel(II) and -platinum(II) complex cations

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989020014437 ◽

2020 ◽

Vol 76 (12) ◽

pp. 1813-1817

Author(s):

Masatoshi Mori ◽

Takayoshi Suzuki

Keyword(s):

Crystal Structure ◽

Crystal Structures ◽

Steric Hindrance ◽

Molecular Structures ◽

Coordination Geometry ◽

Donor Group ◽

Bending Deformation ◽

Bond Lengths ◽

Square Planar ◽

Chelate Ligands

The crystal structures of the complexes (SP-4-2)-cis-bis[8-(dimethylphosphanyl)quinoline-κ2 N,P]nickel(II) bis(perchlorate) nitromethane monosolvate, [Ni(C11H12NP)2](ClO4)2·CH3NO2 (1), and (SP-4-2)-cis-bis[8-(dimethylphosphanyl)quinoline-κ2 N,P]platinum(II) bis(tetrafluoroborate) acetonitrile monosolvate, [Pt(C11H12NP)2](BF4)2·C2H3N (2), are reported. In both complex cations, two phosphanylquinolines act as bidentate P,N-donating chelate ligands and form the mutually cis configuration in the square-planar coordination geometry. The strong trans influence of the dimethylphosphanyl donor group is confirmed by the Ni—N bond lengths in 1, 1.970 (2) and 1.982 (2) Å and, the Pt—N bond lengths of 2, 2.123 (4) and 2.132 (4) Å, which are relatively long as compared to those in the analogous 8-(diphenylphosphanyl)quinoline complexes. Mutually cis-positioned quinoline donor groups would give a severe steric hindrance between their ortho-H atoms. In order to reduce such a steric congestion, the NiII complex in 1 shows a tetrahedral distortion of the coordination geometry, as parameterized by τ4 = 0.199 (1)°, while the PtII complex in 2 exhibits a typical square-planar coordination geometry [τ4 = 0.014 (1)°] with a large bending deformation of the ideally planar Me2Pqn chelate planes. In the crystal structure of 2, three F atoms of one of the BF4 − anions are disordered over two sets of positions with refined occupancies of 0.573 (10) and 0.427 (10).

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Crystal structure ofcatena-poly[[[bis(pyridine-4-carbothioamide-κN1)cadmium]-di-μ-thiocyanato-κ2N:S;κ2S:N] methanol disolvate]

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989016002632 ◽

2016 ◽

Vol 72 (3) ◽

pp. 370-373 ◽

Cited By ~ 3

Author(s):

Tristan Neumann ◽

Inke Jess ◽

Christian Näther

Keyword(s):

Crystal Structure ◽

Hydrogen Bonds ◽

Title Compound ◽

Methanol Molecule ◽

Donor Group ◽

Asymmetric Unit ◽

Thiocyanate Anion ◽

Anionic Ligands ◽

Hydrogen Bonded

The asymmetric unit of the polymeric title compound, {[Cd(NCS)2(C6H6N2S)]·2CH3OH}n, consists of one cadmium(II) cation that is located on a centre of inversion as well as one thiocyanate anion, one pyridine-4-carbothioamide ligand and one methanol molecule in general positions. The CdIIcations are octahedrally coordinated by the pyridine N atom of two pyridine-4-carbothioamide ligands and by the S and N atoms of four thiocyanate anions and are linked into chains along [010] by pairs of anionic ligands. These chains are further linked into layers extending along (201) by intermolecular N—H...O and O—H...S hydrogen bonds. One of the amino H atoms of the pyridine-4-carbothioamide ligand is hydrogen-bonded to the O atom of a methanol molecule, and a symmetry-related methanol molecule is the donor group to the S atom of another pyridine-4-carbothioamide ligand whereby each of the pyridine-4-carbothioamide ligands forms two pairs of centrosymmetric N—H...S and O—H...S hydrogen bonds. The methanol molecules are equally disordered over two orientations.

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