Veterinary Drug Residues Survey in Meat:  An HPLC Method with a Matrix Solid Phase Dispersion Extraction

1997 ◽  
Vol 45 (6) ◽  
pp. 2134-2142 ◽  
Author(s):  
Stéphanie Le Boulaire ◽  
Jean-Claude Bauduret ◽  
François Andre
Keyword(s):  
Solid Phase ◽  
Hplc Method ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion

scholarly journals New Vortex-Synchronized Matrix Solid-Phase Dispersion Method for Simultaneous Determination of Four Anthraquinones in Cassiae Semen

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1312
Author(s):  
Luyi Jiang ◽  
Jie Wang ◽  
Huan Zhang ◽  
Caijing Liu ◽  
Yiping Tang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
High Performance ◽  
Solid Phase ◽  
Hplc Method ◽  
Factors Affecting ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Quantitative Determination Method ◽  
Grinding Time

In this study, a green ionic-liquid based vortex-synchronized matrix solid-phase dispersion (VS-MSPD) combined with high performance liquid chromatography (HPLC) method was developed as a quantitative determination method for four anthraquinones in Cassiae Semen. Two conventional adsorbents, C18 and silica gel were investigated. The strategy included two steps: Extraction and determination. Wasted crab shells were used as an alternative adsorbent and ionic liquid was used as an alternative solvent in the first step. Factors affecting extraction efficiency were optimized: A sample/adsorbent ratio of 2:1, a grinding time of 3 min, a vortex time of 3 min, and ionic liquid ([Domim]HSO4, 250 mM) was used as eluent in the VS-MSPD procedure. As a result, the established method provided satisfactory linearity (R > 0.999), good accuracy and high reproducibility (RSD < 4.60%), and it exhibited the advantages of smaller sample amounts, shorter extraction time, less volume of elution solvent, and was much more environmental-friendly when compared with other conventional methods.

scholarly journals Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS

2021 ◽  
Author(s):  
Wentao Zhao ◽  
Rui Jiang ◽  
Wenping Guo ◽  
Chao Guo ◽  
Shilei Li ◽  
...  
Keyword(s):  
Solid Phase ◽  
Sample Pretreatment ◽  
Veterinary Drugs ◽  
Food Sources ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Animal Source ◽  
Solid Phase Extraction Cartridge ◽  
Relative Standard

AbstractA rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatography coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1 µg/kg to 10 µg/kg. The recovery rates were between 79.2 and 118.5 % in all matrices studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples.

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