Stereospecific Cyclopropanation of Highly Substituted C−C Double Bonds Promoted by CrCl2. Stereoselective Synthesis of Cyclopropanecarboxamides and Cyclopropyl Ketones
An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the expeditious synthesis of trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions.