Facile Synthesis of Enantioenriched Cγ-Tetrasubstituted α-Amino Acid Derivatives via an Asymmetric Nucleophilic Addition/Protonation Cascade

2011 ◽  
Vol 13 (9) ◽  
pp. 2290-2293 ◽  
Author(s):  
Shu-Wen Duan ◽  
Jing An ◽  
Jia-Rong Chen ◽  
Wen-Jing Xiao
Keyword(s):  
Amino Acid ◽  
Nucleophilic Addition ◽  
Amino Acid Derivatives ◽  
Facile Synthesis

Facile Synthesis of a “Ready to Use” Precursor of Porphobilinogen and Its Amino Acid Derivatives

2008 ◽  
Vol 73 (2) ◽  
pp. 764-767 ◽  
Author(s):  
Carole Pissot Soldermann ◽  
Ramakrishnan Vallinayagam ◽  
Manuel Tzouros ◽  
Reinhard Neier
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Facile Synthesis

Amino Acid Derivatives in Organic Synthesis, Part 4 [1]: Facile Synthesis of Heterocycles Containing a Glycine Residue

2000 ◽  
Vol 55 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Laila M. Chabaka ◽  
Yehia A. Allam ◽  
Galal A. M. Nawwar
Keyword(s):  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Group ◽  
The Other ◽  
Amino Acid Derivatives ◽  
Carboxylic Acid Group ◽  
Facile Synthesis ◽  
Peptide Linkage ◽  
Active Methylene Compounds ◽  
Active Methylene

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition - intracyclization synthetic pathway.Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7]

ChemInform Abstract: Facile Synthesis of a “Ready to Use” Precursor of Porphobilinogen and Its Amino Acid Derivatives.

ChemInform ◽  
2008 ◽  
Vol 39 (21) ◽  
Author(s):  
Carole Soldermann-Pissot ◽  
Ramakrishnan Vallinayagam ◽  
Manuel Tzouros ◽  
Reinhard Neier
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Facile Synthesis

scholarly journals New Method for Synthesis of Substituted N-Borylated Dipeptides Based on Acetonitrile Derivative of the closo-Dodecaborate Anion

2021 ◽  
Vol 66 (9) ◽  
pp. 1390-1395
Author(s):  
A. V. Nelyubin ◽  
N. A. Selivanov ◽  
I. N. Klyukin ◽  
A. Yu. Bykov ◽  
A. P. Zhdanov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Nmr Spectroscopy ◽  
Absorption Spectroscopy ◽  
Nucleophilic Addition ◽  
New Method ◽  
Amino Acid Derivatives ◽  
Ir Absorption ◽  
Multinuclear Nmr Spectroscopy ◽  
Esi Mass Spectrometry

Abstract A new multistage synthesis of the N-borylated dipeptide B12-PheGlyOH has been proposed. The approach is based on the reaction of nucleophilic addition of amino acid derivatives to the [B12H11NCCH3]– anion. The products of each stage have been characterized by multinuclear NMR spectroscopy, IR absorption spectroscopy, and ESI mass spectrometry.

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