Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

scholarly journals Antioxidant and Oxidant Status of Endemic Helleborus vesicarius

2020 ◽  
Vol 8 (9) ◽  
pp. 2008-2010
Author(s):  
Falah Saleh Mohammed ◽  
Gülcan Çınar ◽  
Serap Sahin Yigit ◽  
Hasan Akgül ◽  
Muhittin Dogan
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Oxidative Stress Index ◽  
Aerial Parts ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Plants are important antioxidant sources. In our study, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of endemic Helleborus vesicarius Aucher ex Boiss.were determined. The aerial parts of the plant samples were dried and extracted with ethanol (EtOH). TAS and TOS values of plant extract were determined using Rel Assay Diagnostics kits. As a result of the studies, the TAS value of H. vesicarius was determined 5.548±0.23, the TOS value was 13.778±0.119 and the OSI value was 0.249±0.009. In this context, the plant has been shown to have significant antioxidant potential.

Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

2016 ◽  
Vol 27 (2) ◽  
pp. 325-332
Author(s):  
Firat H. Altin ◽  
Hayriye A. Yildirim ◽  
Ibrahim C. Tanidir ◽  
Okan Yildiz ◽  
Meliha Z. Kahraman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Antioxidant Status ◽  
Congenital Heart ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Total Antioxidant ◽  
Oxidant Status

AbstractObjectiveOxidative stress refers to an imbalance between reactive oxidative species and antioxidants. In this case-controlled, prospective, observational study, we investigated the total oxidant status, total antioxidant status, oxidative stress index, and albumin and C-reactive protein levels of children with cyanotic and acyanotic congenital heart diseases who had undergone on-pump cardiac surgery.MethodThe study groups consisted of 60 patients with congenital heart disease, who were operated under cardiopulmonary bypass, and a control group of 30 healthy individuals. The patients were classified into two groups. Among them, one was a patient group that consisted of 30 patients with acyanotic congenital heart disease and the other group consisted of 30 patients with cyanotic congenital heart disease. In the patient groups, blood samples were collected before surgery and at one and 24 hours following surgery. In control groups, blood samples were collected once during hospital admission.ResultsNo statistically significant differences were found between the groups in terms of baseline total oxidant status, total antioxidant status, and oxidative stress index values. Regarding the postoperative first-hour and 24-hour total oxidant status and total antioxidant status levels as well as oxidative stress index values, there were no significant differences between the groups, except for an increase in total antioxidant status levels (p=0.002) 24 hours after surgery in cyanotic patients.ConclusionThere was no difference between oxidative stress status of cyanotic and acyanotic congenital heart disease patients and healthy individuals. Oxidative stress status of cyanotic and acyanotic patients does not change after cardiac surgery under cardiopulmonary bypass.

scholarly journals Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

2019 ◽  
Vol 31 (3) ◽  
pp. 719-722
Author(s):  
Hathama Razooki Hasan ◽  
Nuha Nihad A. Aburahma ◽  
Abdul Kareem A. AL-Kazaz
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

The present study aimed to look for the differences in the oxidative stress status in sera and saliva samples of type 2 diabetic Iraqi patients with and without proliferative diabetic retinopathy. As well as to look for the possibility whether this status can be measured in saliva as an alternative sample to that of serum, hence to achieve that total oxidant status, total antioxidant status and oxidative stress index were measured in both sera and saliva samples of two groups of patients with type 2 diabetes mellitus and the healthy individuals. Upon the comparison between patients without proliferative diabetic retinopathy and the control sample the results showed presence of a significant increase (p < 0.05) of total oxidant status and oxidative stress index in sera and saliva samples, while there was a significant decrease (p < 0.05) in total antioxidant status of sera and saliva samples. Meanwhile when the comparison was done between patients with proliferative diabetic retinopathy and those without proliferative diabetic retinopathy, a significant increase (p < 0.05) in both salivary total oxidant status and oxidative stress index was observed with a significant decrease (p < 0.05) in sera and salivary total antioxidant status were found in the proliferative diabetic retinopathy patients group.

scholarly journals Antioxidant Potential of Endemic Salvia absconditiflora

2020 ◽  
Vol 8 (10) ◽  
pp. 2222-2224
Author(s):  
Hasan Akgul ◽  
Nuh Korkmaz ◽  
Alpaslan Dayangaç ◽  
Mustafa Sevindik
Keyword(s):  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Oxidative Stress Index ◽  
Plant Samples ◽  
Total Antioxidant ◽  
Materials Used ◽  
Oxidant Status ◽  
And Oxidative Stress

Medicinal plants are important natural materials used in the treatment of many diseases. In this study, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of endemic Salvia absconditiflora Greuter & Burdet were determined. Plant samples were collected from Nigde and Erzincan (Turkey) provinces. Ethanol (EtOH) extracts of plant samples were extracted. TAS, TOS and OSI values were determined using Rel Assay Diagnostics kits. As a result of the studies, it has been determined that the samples of the plant collected from Nigde have higher TAS, TOS and OSI values. As a result, it has been determined that S. absconditiflora can be used as a potential antioxidant source due to high TAS values.

scholarly journals Önemli Tıbbi Bitkilerden Biri Olan Achillea millefolium L. (Civanperçemi) Bitkisinin Besin Elementi Konsantrasyonları ve Antioksidan Aktivitesi

2021 ◽  
Vol 9 (3) ◽  
pp. 590-594
Author(s):  
Handan Saraç ◽  
Hasan Durukan ◽  
Ahmet Demirbaş
Keyword(s):  
Oxidative Stress ◽  
Water Extract ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Achillea Millefolium ◽  
Nutrient Concentrations ◽  
Oxidative Stress Index ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

In this study, it was aimed to determine the nutrient concentrations and antioxidant activity of Achillea millefolium L. (Yarrow), which is known to have medicinal properties. For this purpose, macro and micronutrient concentrations, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of water extract Yarrow plant, which is known to be collected from Divrigi district in Sivas province, were determined. The results have shown that the yarrow plant is sufficient in terms of some macro and micronutrient concentrations, and the nitrogen (N), phosphorus (P), potassium (K), calcium (Ca) and magnesium from macro elements, iron (Fe), zinc (Zn), manganese (Mn) and copper (Cu) from micro elements concentrations were determined as 1.01% N, 0.63% P, 2.43% K, 2.22% Ca, 0.70% Mg, 360.4 mg kg-1 Fe, 47.6 mg kg-1 Zn, 85.5 mg kg-1 Mn and 28.3 mg kg-1 Cu, respectively. It has been determined that its antioxidant potential is moderate. In addition, the plant’s oxidant capacity and oxidative stress index were found to be low.

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