Supplemental Material for Personality Method Validation in Common Marmosets (Callithrix jacchus): Getting the Best of Both Worlds

2020 ◽  
Vol 134 (1) ◽  
pp. 52-70 ◽  
Author(s):  
Vedrana Šlipogor ◽  
Judith Maria Burkart ◽  
Jordan Scott Martin ◽  
Thomas Bugnyar ◽  
Sonja Elena Koski

2014 ◽  
Vol 28 (2) ◽  
pp. 48-57
Author(s):  
Yu.K. Novoderzhkina ◽  
◽  
T.V. Gulyaeva ◽  
Yu.A.-K. Khubiev ◽  
I.V. Gorgeychuk ◽  
...  

2021 ◽  
Vol 173 ◽  
pp. 115-136
Author(s):  
J.S. Martin ◽  
S.E. Koski ◽  
T. Bugnyar ◽  
A.V. Jaeggi ◽  
J.J.M. Massen

Author(s):  
Anna Goodroe ◽  
Lynn Wachtman ◽  
William Benedict ◽  
Krystal Allen‐Worthington ◽  
Jaco Bakker ◽  
...  

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 963
Author(s):  
Sandra Roubos ◽  
Annet L. Louwerse ◽  
Jan A. M. Langermans ◽  
Jaco Bakker

Contraception is an important population control method for the colony management of primates housed in captivity. Etonogestrel (ENG) implants (i.e., Implanon®) are a widely used progestin-based contraceptive in common marmosets (Callithrix jacchus) with the theoretical advantages of being reversible and long-acting. However, no dose and efficacy data are available yet. Therefore, data from 52 adult female marmosets contracepted with ENG (one-fourth or one-third of an implant) housed at the Biomedical Primate Research Centre (BPRC, Rijswijk, The Netherlands) over the past 18 years were analyzed. Using an electronic database, a retrospective longitudinal cohort study was conducted to calculate the reproductive data before, during and after ENG use. The data show an effectiveness in preventing pregnancy of 99%. The implant was effective within one week after insertion. Unintended pregnancies did occur, but in 60% of these cases, the animals were already pregnant at the time of implant insertion. In these cases, healthy offspring were born despite the use of the implant. No stillbirths, neonatal deaths or maternal deaths could be linked to ENG use. After implant removal, 83% of the animals delivered healthy offspring. No difference in contraception efficacy was observed between the use of one-fourth or one-third of an implant. ENG achieved a contraceptive protection exceeding 99% and was shown to be reversible concerning fertility. To our knowledge, this is the first detailed analysis on the use of ENG in marmosets.


2018 ◽  
Vol 8 (12) ◽  
pp. e01148
Author(s):  
Viviane Brito Nogueira ◽  
Danilo Oliveira Imparato ◽  
Sandro José de Souza ◽  
Maria Bernardete Cordeiro de Sousa

2013 ◽  
Vol 126 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Christoph Curths ◽  
Judy Wichmann ◽  
Sarah Dunker ◽  
Horst Windt ◽  
Heinz-Gerd Hoymann ◽  
...  

Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics for respiratory diseases. The aim of the present study was to examine lung-function parameters in marmoset monkeys (Callithrix jacchus) that can be used to detect pharmacologically or provocation-induced AHR (airway hyper-responsiveness). Therefore a custom-made lung-function device that allows application of defined aerosol doses during measurement was developed. It was hypothesized that LPS (lipopolysaccharide)-challenged marmosets show AHR compared with non-challenged healthy subjects. Invasive plethysmography was performed in 12 anaesthetized orotracheally intubated and spontaneously breathing marmosets. Pulmonary data of RL (lung resistance), Cdyn (dynamic compliance), EF50 (mid-expiratory flow), Poes (oesophageal pressure), MV (minute volume), respiratory frequency (f) and VT (tidal volume) were collected. Measurements were conducted under baseline conditions and under MCh (methacholine)-induced bronchoconstriction. The measurement was repeated with the same group of animals after induction of an acute lung inflammation by intratracheal application of LPS. PDs (provocative doses) of MCh to achieve a certain increase in RL were significantly lower after LPS administration. AHR was demonstrated in the LPS treated compared with the naïve animals. The recorded lung-function data provide ground for pre-clinical efficacy and safety testing of anti-inflammatory substances in the common marmoset, a new translational NHP (non-human primate) model for LPS-induced lung inflammation.


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