A Randomized Prospective Trial Comparing Paravertebral Block and General Anesthesia for Operative Treatment of Breast Cancer

2003 ◽  
Author(s):  
Christina R. Weltz ◽  
Keyword(s):  
Breast Cancer ◽  
General Anesthesia ◽  
Operative Treatment ◽  
Prospective Trial ◽  
Paravertebral Block ◽  
Randomized Prospective Trial

A Randomized Prospective Trial of Supine MRI-Guided Versus Wire-Localized Lumpectomy for Breast Cancer

2019 ◽  
Vol 26 (10) ◽  
pp. 3099-3108 ◽  
Author(s):  
Richard J. Barth ◽  
Venkataramanan Krishnaswamy ◽  
Keith D. Paulsen ◽  
Timothy B. Rooney ◽  
Wendy A. Wells ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prospective Trial ◽  
Randomized Prospective Trial ◽  
Mri Guided

scholarly journals Serum IL-6 Level in Breast Cancer Surgery: Evaluating the Addition of Hydrocortisone to Two Anesthetic Regimens

2015 ◽  
Vol 9 (1) ◽  
pp. 29-35
Author(s):  
Sherif Abdelhamid ◽  
Ahmed Talha ◽  
Salwa Hamdy ◽  
Ashraf Arafat Abdelhalim ◽  
Mohamed Elakany
Keyword(s):  
Breast Cancer ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Cancer Surgery ◽  
Paravertebral Block ◽  
Breast Cancer Surgery ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Thoracic Paravertebral Block

Background: This study was purposed to compare in vitro the volumetric accuracy of a newly introduced automatic infusion controller, AutoClamp with that of other commonly used infusion devices. Methods: In this prospective, randomized, controlled trial, 124 ASA I-II, female patients, aged 30-50 years, undergoing conservative breast cancer surgery were randomly assigned to one of four equal groups receiving either standard general anesthesia and two doses of hydrocortisone (Group GH, n=31), thoracic paravertebral block and two doses of hydrocortisone (Group PH, n=31), standard general anesthesia with no hydrocortisone (Group G, n=31), or thoracic paravertebral block with no hydrocortisone (Group P, n=31). IL-6 was measured at three time points: before operation, 6 and 12 hours postoperatively. CRP and cortisol were measured preoperatively and 6 hours postoperatively. Results: On comparing group PH and GH, there was significant decrease in IL-6 level in group PH compared to group GH at 6 hour (122.1±21.2 vs 135.8±29.8pg/dl), but insignificant difference at 24 hours (107.9±21.6 vs 106.8±15.9pg/dl). CRP showed significant decrease in the postoperative reading in group PH compared to group GH (1.63±0.32 vs 1.91±0.43mg/l), and also group PH showed significant decrease compared to the control group P (1.63±0.32 vs 2.2±0.54). Conclusion: addition of hydrocortisone to general anesthesia or thoracic paravertebral block attenuated production of IL-6 and CRP levels significantly postoperatively compared to either anesthetic regimen alone, but not the serum cortisol level, highlighting its role in modifying the stress response to surgery. However, the effect was more pronounced when combined with thoracic paravertebral block.

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