scholarly journals Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development

2010 ◽  
Vol 5 (7) ◽  
pp. 1324-1336 ◽  
Author(s):  
Philip Roelandt ◽  
Pau Sancho-Bru ◽  
Karen Pauwelyn ◽  
Catherine Verfaillie
Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 966
Author(s):  
Xv Zhang ◽  
Liling Tang ◽  
Qian Yi

The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids.


2013 ◽  
Vol 91 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Sandra A Jacobs ◽  
Valerie D Roobrouck ◽  
Catherine M Verfaillie ◽  
Stefaan W Van Gool

2007 ◽  
Vol 364 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Miguel Barajas ◽  
Federico Franchi ◽  
Carlos Clavel ◽  
Xabier L. Aranguren ◽  
M. Gabriela Kramer ◽  
...  

Author(s):  
Philip R. Roelandt ◽  
Valerie D. Roobrouck ◽  
Catherine M. Verfaillie

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0202118 ◽  
Author(s):  
Olla Al-Jaibaji ◽  
Stephen Swioklo ◽  
Kristel Gijbels ◽  
Bart Vaes ◽  
Francisco C. Figueiredo ◽  
...  

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