scholarly journals The impact of donor CMV infection on kidney graft outcome

2013 ◽  
Vol 9 (8) ◽  
pp. 434-434 ◽  
Author(s):  
Ellen F. Carney
Keyword(s):  
Kidney Graft ◽  
Cmv Infection ◽  
Graft Outcome ◽  
The Impact

The Impact of Functional Status of Arteriovenous Fistula On Kidney Graft Outcome: a National Cohort Study.

2014 ◽  
Vol 98 ◽  
pp. 637
Author(s):  
Vajdic B. Trampuz ◽  
M. Arnol ◽  
R. Ponikvar ◽  
A. Kandus ◽  
J. Buturovic-Ponikvar
Keyword(s):  
Cohort Study ◽  
Functional Status ◽  
Arteriovenous Fistula ◽  
Kidney Graft ◽  
Graft Outcome ◽  
National Cohort ◽  
The Impact

scholarly journals Perfusate metabolomics content and tubular transporters expression during kidney graft preservation by hypothermic machine perfusion

2021 ◽  
Author(s):  
Quentin Faucher ◽  
Hugo Alarcan ◽  
François-Ludovic Sauvage ◽  
Lionel Forestier ◽  
Elodie Miquelestorena-Standley ◽  
...  
Keyword(s):  
Multivariate Analyses ◽  
Kidney Graft ◽  
Invasive Approach ◽  
Non Invasive ◽  
Graft Outcome ◽  
Hypothermic Perfusion ◽  
Hypothermic Machine Perfusion ◽  
Perfusion Time ◽  
The Impact ◽  
Implantation Period

AbstractBackgroundIschemia-related injury during the pre-implantation period impacts kidney graft outcome. Evaluating these lesions by a non-invasive approach before transplantation could help to understand the mechanisms of graft injury and identify potential biomarkers predictive of graft outcomes. This study aims to determine metabolomic content of graft perfusion fluids and its dependence on preservation time and to explore whether tubular transporters are possibly involved in the metabolomics variations observed.MethodsKidneys were stored on hypothermic perfusion machines. We evaluated the metabolomic profiles of perfusion fluids (n=35) using Liquid Chromatography coupled with tandem Mass Spectrometry and studied the transcriptional expression of tubular transporters on pre-implantation biopsies (n=26). We used univariate and multivariate analyses to assess the impact of perfusion time on these parameters and their relationship with graft outcome.ResultsSeventy-two metabolites were found in preservation fluids at the end of perfusion, of which 40% were already present in the native conservation solution. We observed an increase of 23 metabolites with longer perfusion time and a decrease for 8. The predictive model for time-dependent variation of metabolomics content showed good performance (R2= 76%, Q2= 54%, accuracy= 41%, permutations test significant). Perfusion time had no effect on the mRNA expression of transporters. We found no correlation between metabolomics and transporters expression. Neither the metabolomics profile nor the transporters expression were predictive of graft outcome.ConclusionOur results open the way for further studies, focusing on both intra- and extra-tissue metabolome, to investigate whether transporter alterations can explain the variations observed in pre-implantation period.

Alport syndrome: HLA association and kidney graft outcome

2004 ◽  
Vol 31 (3) ◽  
pp. 115-119 ◽  
Author(s):  
S. Barocci ◽  
S. Fiordoro ◽  
G. Santori ◽  
U. Valente ◽  
M. Mossa ◽  
...  
Keyword(s):  
Alport Syndrome ◽  
Kidney Graft ◽  
Hla Association ◽  
Graft Outcome

Donor risk score and baseline biopsy CADI value predict kidney graft outcome

2011 ◽  
Vol 25 (3) ◽  
pp. E276-E283 ◽  
Author(s):  
Jaanus Kahu ◽  
Lauri Kyllönen ◽  
Anne Räisänen-Sokolowski ◽  
Kaija Salmela
Keyword(s):  
Risk Score ◽  
Kidney Graft ◽  
Graft Outcome

Transition from Antigenemia to Quantitative Nucleic Acid Amplification Testing in Kidney Transplant Recipients Receiving Preemptive Therapy for Cytomegalovirus Infection.

2021 ◽  
Author(s):  
Mônica Rika Nakamura ◽  
Lúcio R. Requião-Moura ◽  
Roberto Mayer Gallo ◽  
Camila Botelho ◽  
Júlia Taddeo ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Nucleic Acid ◽  
Acute Rejection ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Nucleic Acid Amplification ◽  
Rt Pcr ◽  
Cmv Infection ◽  
Preemptive Treatment ◽  
The Impact

Abstract Due to the high costs, the strategy to reduce the impact of cytomegalovirus (CMV) after kidney transplant (KT) involves preemptive treatment in low and middle-income countries. Thus, this retrospective cohort study compared the performance of antigenemia transitioned to quantitative nucleic acid amplification testing, RT-PCR, in KT recipients receiving preemptive treatment as a strategy to prevent CMV infection. Between 2016 and 2018, 363 patients were enrolled and received preemptive treatment based on antigenemia (n=177) or RT-PCR (n=186). The primary outcome was CMV infection or disease. There were no differences in one-year cumulative incidence of CMV-related events (50.8% vs. 44.1%, P=0.20), neither in time to diagnosis (47.0 vs. 47.0 days) among patients conducted by antigenemia vs. RT-PCR, respectively. The length of CMV first treatment was longer with RT-PCR (20.0 vs. 27.5 days, P<0.001), while the rate of retreatment was not different (14.7% vs. 11.8%, P=0.48). In the Cox regression, the variables associated with CMV-related events were acute rejection within 30 days (HR=2.05, p=0.01) and 30-day glomerular filtration rate (HR=0.98, p<0.001). In conclusion, acute rejection and glomerular filtration rate are risk factors for CMV infection and disease, showing comparable performance in the impact of CMV-related events between antigenemia and RT-PCR for preemptive treatment.

Pretransplant serum IgG-anti-F(ab′)2γ activity and kidney graft outcome: comparison of results obtained at two centers

1992 ◽  
Vol 5 ◽  
pp. S625-S626 ◽  
Author(s):  
C. Süsal ◽  
J. Groth ◽  
H.-H. Oberg ◽  
P. Terness ◽  
G. May ◽  
...  
Keyword(s):  
Kidney Graft ◽  
Comparison Of Results ◽  
Graft Outcome ◽  
Serum Igg ◽  
Outcome Comparison

Assessing the potential of angiotensin II type 1 receptor and donor specific anti-endothelial cell antibodies to predict long-term kidney graft outcome

2017 ◽  
Vol 78 (5-6) ◽  
pp. 421-427 ◽  
Author(s):  
David F. Pinelli ◽  
John J. Friedewald ◽  
Kelley M.K. Haarberg ◽  
Shree L. Radhakrishnan ◽  
Jennifer R. Zitzner ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Angiotensin Ii ◽  
Kidney Graft ◽  
Graft Outcome

HLA specificity of post-transplant alloantibodies and kidney graft outcome

2002 ◽  
Vol 63 (10) ◽  
pp. S78
Author(s):  
Antonina Piazza ◽  
Elvira Poggi ◽  
Laura Borrelli ◽  
Giuseppina Ozzella ◽  
Palmina I Monaco ◽  
...  
Keyword(s):  
Kidney Graft ◽  
Post Transplant ◽  
Graft Outcome
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