Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment

Background and Objective: Obesity is becoming a global issue related to many health problems, and infertility is one of them. It has been established in literature that obesity or increased body mass index (BMI) harms the ability of a woman to conceive. Assisted reproductive techniques e.g., in-vitro fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) are helping infertile women to conceive. This study's objective was to analyze the effect of BMI on IVF/ICSI treatment outcomes in infertile women. Methods: This was a retrospective cross-sectional study. Samples of 500 patients aged less than 40 years were selected at a tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital. The sample was collected from January 2019 to June 2019. A structured proforma was used to collect information about selected anthropometric measurements and ultrasonography findings from the files and follow-ups of the selected patients. Data was processed and analyzed in Statistical Package for Social Sciences (SPSS) version 20.0. Results: The age of the subjects ranged from 18 to 39 years, with a maximum number of subjects in the age category 31 to 35 years. BMI was significantly associated with number of follicles retrieved and clinical pregnancy rate (P= 0.001). Conclusion: Normal BMI has positive impact both on follicular response in controlled ovarian stimulation (COS) and clinical pregnancy rates in women undergoing IVF/ICSI treatment.

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The Effect of Maternal Body Mass Index on In Vitro Fertilization-Intracytoplasmic Sperm Injection Treatment: A Prospective Comparative Study

10.21203/rs.3.rs-298772/v1 ◽

2021 ◽

Author(s):

Zeynep Ozturk Inal ◽

Hasan Ali Inal

Keyword(s):

Body Mass Index ◽

In Vitro Fertilization ◽

Body Mass ◽

Intracytoplasmic Sperm Injection ◽

Endometrial Thickness ◽

Maternal Body Mass Index ◽

Maternal Body ◽

Vitro Fertilization ◽

Stimulating Hormone

Abstract Purpose: To evaluate whether or not maternal body mass index (BMI) has an effect on pregnancy rates following in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) treatment.Methods: A total of 869 patients who had undergone IVF-ICSI treatment between 2012 and 2017 were included in this study. The participants were stratified according to maternal BMI as Group 1 (BMI<25 kg/m2; n=394), Group 2 (25 kg/m2<BMI <30 kg/m2; n=303), and Group 3 (BMI>25 kg/m2; n=172). Basal parameters and IVF-ICSI outcomes were compared between the groups.Results: While there were no differences between the groups in terms of age, smoking status, etiology of infertility, thyroid-stimulating hormone, prolactin levels, antral follicle count, and stimulation protocol (p>0.05), there was significant statistical difference (p<0.05) in terms of BMI, duration of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol (E2), duration of stimulation, total gonadotropin dose required, peak E2 levels, progesterone levels, endometrial thickness on hCG administration, and cycle cancellation rate. In addition, the numbers of MII and 2PN oocytes retrieved and the rates of clinical pregnancy, live births, and miscarriages were also different between the groups (p<0.05).Conclusion: Our data suggest that there is an inverse impact of increased BMI on laboratory and reproductive outcome parameters of IVF-ICSI treatment. Taking cost-effectiveness into consideration, weight loss should be suggested before ovulation is induced.

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