ERBB2 amplification status in 67 salivary duct carcinomas assessed by immunohistochemistry, fluorescence in situ hybridization, and targeted exome sequencing

2021 ◽  
Author(s):  
Donna C. Ferguson ◽  
Amir Momeni Boroujeni ◽  
Tao Zheng ◽  
Abhinita S. Mohanty ◽  
Alan L. Ho ◽  
...  
2011 ◽  
Vol 135 (9) ◽  
pp. 1088-1091 ◽  
Author(s):  
Hyun-Jung Kim ◽  
Young Sam Yoo ◽  
Kyeongmee Park ◽  
Ji-Eun Kwon ◽  
Jung Yeon Kim ◽  
...  

Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial parotidectomy showed a solid mass around the cyst wall. The tumor cells of the solid area were arranged as infiltrative ducts with a few foci of malignant transformation. Virtual karyotyping disclosed a complex pattern of genetic aberrations with a focal amplification in 12q14–q21.2. This chromosomal region contains the MDM2 (murine double minute) gene, which regulates p53 inactivation. HER2 fluorescence in situ hybridization showed a focal amplification. Subsequently, the patient underwent total parotidectomy and ipsilateral neck dissection for a recurrence. To our knowledge, this is the first case of salivary duct carcinoma arising from Warthin tumor. The essential molecular pathway has not been reported, we presume an important role of MDM2 amplification–P53 inactivation.


1992 ◽  
Vol 89 (12) ◽  
pp. 5321-5325 ◽  
Author(s):  
O. P. Kallioniemi ◽  
A. Kallioniemi ◽  
W. Kurisu ◽  
A. Thor ◽  
L. C. Chen ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 287-288 ◽  
Author(s):  
Juliann M. Dziubinski ◽  
Michael F. Sarosdy ◽  
Paul R. Kahn ◽  
Mark D. Ziffer ◽  
William R. Love ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 156-156
Author(s):  
Chandler D. Dora ◽  
Yasushi Kondo ◽  
Fusheng X. Lan ◽  
Jeffrey M. Slezak ◽  
Erik J. Bergstralh ◽  
...  

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