Exploiting lipotoxicity for the treatment of liver cancer
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SummaryMetabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
2020 ◽
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1985 ◽
Vol 249
(5)
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pp. H1024-H1030
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1968 ◽
Vol 97
(6)
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pp. 722-726
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Keyword(s):