TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

2022 ◽  
Author(s):  
Dong Suk Yoon ◽  
Kyoung-Mi Lee ◽  
Yoorim Choi ◽  
Eun Ae Ko ◽  
Na-Hyun Lee ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cellular Aging

scholarly journals Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

2001 ◽  
Vol 21 (17) ◽  
pp. 5889-5898 ◽  
Author(s):  
Wengong Wang ◽  
Xiaoling Yang ◽  
Vincent J. Cristofalo ◽  
Nikki J. Holbrook ◽  
Myriam Gorospe
Keyword(s):  
Gene Expression ◽  
Rna Binding ◽  
Replicative Senescence ◽  
Binding Protein ◽  
Expression Patterns ◽  
Critical Role ◽  
Rna Binding Protein ◽  
Cellular Aging ◽  
Gene Expression Patterns ◽  
Senescent Phenotype

ABSTRACT Cellular aging is accompanied by alterations in gene expression patterns. Here, using two models of replicative senescence, we describe the influence of the RNA-binding protein HuR in regulating the expression of several genes whose expression decreases during senescence. We demonstrate that HuR levels, HuR binding to target mRNAs encoding proliferative genes, and the half-lives of such mRNAs are lower in senescent cells. Importantly, overexpression of HuR in senescent cells restored a “younger” phenotype, while a reduction in HuR expression accentuated the senescent phenotype. Our studies highlight a critical role for HuR during the process of replicative senescence.

235: The RNA-Binding Protein IMP3: A Novel Molecular Marker Predicts Progression of Superficial (TA and T1) Urothelial Carcinomas of Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 78-79
Author(s):  
Lioudmila Sitnikova ◽  
Gary Mendese ◽  
Qin Lui ◽  
Bruce A. Woda ◽  
Di Lu ◽  
...  
Keyword(s):  
Molecular Marker ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Urothelial Carcinomas
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