Evaluation of vessel density in healthy subjects with family history of glaucoma

AbstractPurposeSerotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.MethodsEight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.ResultsSERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.ConclusionsThe results with regard to the midbrain SERT level suggest the heritability of MDD.

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Effect of Demographic Status and Lifestyle Habits on Glycaemic Levels in Apparently Healthy Subjects: A Cross-Sectional Study

Journal of Diabetes Research ◽

10.1155/2016/5240503 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Kasuni Nisansala Wijesena Walatara ◽

Lohini Vijayendran Athiththan ◽

Usha Kumari Hettiaratchi ◽

Pradeep Rasika Perera

Keyword(s):

Family History ◽

Healthy Subjects ◽

Vigorous Physical Activity ◽

Fasting Blood Glucose ◽

Positive Family History ◽

Monthly Income ◽

Lifestyle Habits ◽

Family History Of Diabetes ◽

History Of ◽

Apparently Healthy

Aim. To identify the effects of sociodemographic status, family history, and lifestyle habits on fasting blood glucose (FBG) and fasting serum insulin (FSI) levels in apparently healthy subjects.Methods. Information was gathered using an interviewer-administered questionnaire from 227 apparently healthy nondiabetic subjects residing in a suburban area in Sri Lanka. Venous blood samples were collected after an overnight fast for FBG and FSI analysis. Correlations and differences were analyzed using SPSS (ver. 17) software.Results. The majority of the subjects were females, having secondary or tertiary education, monthly income ≥Rs. 25,000 (USD 175), and a positive family history of diabetes. Among the subjects, 10.1% were identified as prediabetics and the majority had familial diabetes with monthly income ≥Rs. 25,000 (USD 175). Subjects with high income had significantly higher mean FBG. In addition FBG had a significant correlation with age. Males and subjects with less than 6 hours/day sleeping duration at night had significantly higher FBG. Subjects with less vigorous physical activity and longer sitting duration had significantly higher FSI levels.Conclusions. Increasing age, higher income, positive familial history of diabetes, sedentary lifestyle, and short sleep at night have positive impact on glycaemic status in apparently healthy subjects.

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