scholarly journals Mechanically interlocked 3D multi-material micromachines

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
C. C. J. Alcântara ◽  
F. C. Landers ◽  
S. Kim ◽  
C. De Marco ◽  
D. Ahmed ◽  
...  
Keyword(s):  
Drug Loading ◽  
Three Dimensional ◽  
Dissimilar Materials ◽  
Elastic Behavior ◽  
Small Scale ◽  
Shape Transformation ◽  
On Demand ◽  
Mold Casting ◽  
Metal Organic ◽  
Novel Applications

AbstractMetals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensional metallic and polymeric components. Here, we show that hybrid microstructures can be interlocked by combining 3D lithography, mold casting, and electrodeposition. Our method can be used to achieve complex multi-material microdevices with unprecedented resolution and topological complexity. We show that metallic components can be combined with structures made of different classes of polymers. Properties of both metals and polymers can be exploited in parallel, resulting in structures with high magnetic responsiveness, elevated drug loading capacity, on-demand shape transformation, and elastic behavior. We showcase the advantages of our approach by demonstrating new microrobotic locomotion modes and controlled agglomeration of swarms.

scholarly journals Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junfeng Huang ◽  
Zhourui Xu ◽  
Yihang jiang ◽  
Wing-cheung Law ◽  
Biqin Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Zeolitic Imidazolate Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

AbstractChemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.

scholarly journals Current Trends in Forest Ecological Applications of Three-Dimensional Remote Sensing: Transition from Experimental to Operational Solutions?

Forests ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 891
Author(s):  
Hooman Latifi ◽  
Ruben Valbuena
Keyword(s):  
Remote Sensing ◽  
Forest Ecology ◽  
Three Dimensional ◽  
Remote Sensing Data ◽  
Structure And Function ◽  
Small Scale ◽  
Sensing Data ◽  
Composition Structure ◽  
And Function ◽  
Novel Applications

The alarming increase in the magnitude and spatiotemporal patterns of changes in composition, structure and function of forest ecosystems during recent years calls for enhanced cross-border mitigation and adaption measures, which strongly entail intensified research to understand the underlying processes in the ecosystems as well as their dynamics. Remote sensing data and methods are nowadays the main complementary sources of synoptic, up-to-date and objective information to support field observations in forest ecology. In particular, analysis of three-dimensional (3D) remote sensing data is regarded as an appropriate complement, since they are hypothesized to resemble the 3D character of most forest attributes. Following their use in various small-scale forest structural analyses over the past two decades, these sources of data are now on their way to be integrated in novel applications in fields like citizen science, environmental impact assessment, forest fire analysis, and biodiversity assessment in remote areas. These and a number of other novel applications provide valuable material for the Forests special issue “3D Remote Sensing Applications in Forest Ecology: Composition, Structure and Function”, which shows the promising future of these technologies and improves our understanding of the potentials and challenges of 3D remote sensing in practical forest ecology worldwide.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

scholarly journals 3D Printing of Mini Tablets for Pediatric Use

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Small Scale ◽  
Fused Deposition ◽  
On Demand ◽  
Pediatric Diseases ◽  
Deposition Modeling ◽  
Manufacturing Techniques ◽  
Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

Efficient chemosensors for toxic pollutants based on photoluminescent Zn(II) and Cd(II) metal-organic networks

2021 ◽  
Author(s):  
Luis David Rosales-Vazquez ◽  
Alejandro Dorazco-González ◽  
Victor Sanchez-Mendieta
Keyword(s):  
Optical Sensors ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Environmental Research ◽  
Toxic Pollutants ◽  
Sensitivity And Selectivity ◽  
Metal Organic ◽  
Analytical Tools ◽  
Organic Networks

Optical sensors with high sensitivity and selectivity, as important analytical tools for chemical and environmental research, can be accomplished by straightforward synthesis of luminescent one-, two- and three-dimensional Zn(II) and...

scholarly journals Quantification of Measurement and Model Effects in Monopile Foundation Scour Protection Experiments

2021 ◽  
Vol 9 (6) ◽  
pp. 585
Author(s):  
Minghao Wu ◽  
Leen De Vos ◽  
Carlos Emilio Arboleda Chavez ◽  
Vasiliki Stratigaki ◽  
Maximilian Streicher ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Flow Field ◽  
Three Dimensional ◽  
Small Scale ◽  
Maximum Wave Height ◽  
Chaotic Flow ◽  
The Mean ◽  
Scour Protection ◽  
Damage Number ◽  
Measurement Effects

The present work introduces an analysis of the measurement and model effects that exist in monopile scour protection experiments with repeated small scale tests. The damage erosion is calculated using the three dimensional global damage number S3D and subarea damage number S3D,i. Results show that the standard deviation of the global damage number σ(S3D)=0.257 and is approximately 20% of the mean S3D, and the standard deviation of the subarea damage number σ(S3D,i)=0.42 which can be up to 33% of the mean S3D. The irreproducible maximum wave height, chaotic flow field and non-repeatable armour layer construction are regarded as the main reasons for the occurrence of strong model effects. The measurement effects are limited to σ(S3D)=0.039 and σ(S3D,i)=0.083, which are minor compared to the model effects.

scholarly journals Accelerated Time and High-Resolution 3D Modeling of the Flow and Dispersion of Noxious Substances over a Gigantic Urban Area—The EMERGENCIES Project

Atmosphere ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 640
Author(s):  
Olivier Oldrini ◽  
Patrick Armand ◽  
Christophe Duchenne ◽  
Sylvie Perdriel ◽  
Maxime Nibart
Keyword(s):  
High Resolution ◽  
Urban Area ◽  
3D Modeling ◽  
Three Dimensional ◽  
Hazardous Materials ◽  
Support Tool ◽  
On Demand ◽  
Simulation Domain ◽  
Dimensional Simulation ◽  
Atmospheric Release

Accidental or malicious releases in the atmosphere are more likely to occur in built-up areas, where flow and dispersion are complex. The EMERGENCIES project aims to demonstrate the operational feasibility of three-dimensional simulation as a support tool for emergency teams and first responders. The simulation domain covers a gigantic urban area around Paris, France, and uses high-resolution metric grids. It relies on the PMSS modeling system to model the flow and dispersion over this gigantic domain and on the Code_Saturne model to simulate both the close vicinity and the inside of several buildings of interest. The accelerated time is achieved through the parallel algorithms of the models. Calculations rely on a two-step approach: the flow is computed in advance using meteorological forecasts, and then on-demand release scenarios are performed. Results obtained with actual meteorological mesoscale data and realistic releases occurring both inside and outside of buildings are presented and discussed. They prove the feasibility of operational use by emergency teams in cases of atmospheric release of hazardous materials.

scholarly journals Histidine polypeptide-hybridized nanoscale metal–organic framework to sense drug loading/release

2021 ◽  
Vol 205 ◽  
pp. 109741
Author(s):  
Yanan Xu ◽  
Zhenhua Li ◽  
Dan Xiu ◽  
Guotao Sun ◽  
Christopher D. Snow ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Loading ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

2021 ◽  
pp. 2100014
Author(s):  
Bhanu Nirosha Yalamandala ◽  
Wei‐Ting Shen ◽  
Sheng‐Hao Min ◽  
Wen‐Hsuan Chiang ◽  
Shing‐Jyh Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
On Demand ◽  
Metal Organic
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