scholarly journals Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Qianqian Shi ◽  
Kang Shao ◽  
Hongqin Jia ◽  
Boyang Cao ◽  
Weidong Li ◽  
...  

AbstractInvasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell clusters in multiple lymph node foci arise from a single subclone of the primary tumor. We find evidence that the monoclonal metastatic ancestor in primary IMPC shares high frequency copy-number loss of PRDM16 and IGSF9 and the copy number gain of ALDH2. Immunohistochemistry analysis further shows that low expression of IGSF9 and PRDM16 and high expression of ALDH2 are associated with lymph node metastasis and poor survival of patients with IMPC. We expect these genomic and evolutionary profiles to contribute to the accurate diagnosis of IMPC.

2014 ◽  
Vol 12 (1) ◽  
pp. 84 ◽  
Author(s):  
Kenji Taketani ◽  
Eriko Tokunaga ◽  
Nami Yamashita ◽  
Kimihiro Tanaka ◽  
Yoko Zaitsu ◽  
...  

2016 ◽  
Vol 209 (7-8) ◽  
pp. 331-339 ◽  
Author(s):  
Cíntia C.F. Callegari ◽  
Iglenir J. Cavalli ◽  
Rubens S. Lima ◽  
Tayana S. Jucoski ◽  
Clarissa Torresan ◽  
...  

Surgery Today ◽  
2010 ◽  
Vol 40 (12) ◽  
pp. 1197-1200 ◽  
Author(s):  
Takeo Fujita ◽  
Masaru Konishi ◽  
Naoto Gotohda ◽  
Shinichiro Takahashi ◽  
Toshio Nakagohri ◽  
...  

2014 ◽  
Vol 207 (5) ◽  
pp. 177-187 ◽  
Author(s):  
Clarissa Torresan ◽  
Márcia M.C. Oliveira ◽  
Silma R.F. Pereira ◽  
Enilze M.S.F. Ribeiro ◽  
Catalin Marian ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Ahlam A. Awamleh ◽  
Mihir Gudi ◽  
Sami Shousha

Malignant adenomyoepithelioma of the breast is a rare tumour with around 30 cases reported in the literature. Metastases associated with these tumours are usually haematogenous. Axillary lymph node metastases are thought to be unusual, and it has been recently suggested that axillary node dissection is not indicated unless clinically palpable. We here present a case of a 63-year-old woman, who developed a malignant adenomyoepithelioma with axillary lymph node metastasis, that included epithelial and myoepithelial elements, in spite of the absence of clinically enlarged nodes. We suggest that histological examination of axillary sentinel node(s) or node sampling may be worthwhile in this condition.


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