scholarly journals Author Correction: Genetic relatedness analysis: modern data and new challenges

2021 ◽  
Author(s):  
Bruce S. Weir ◽  
Amy D. Anderson ◽  
Amanda B. Hepler
Keyword(s):  
Genetic Relatedness ◽  
Relatedness Analysis ◽  
New Challenges

Genetic relatedness analysis: modern data and new challenges

2006 ◽  
Vol 7 (10) ◽  
pp. 771-780 ◽  
Author(s):  
Bruce S. Weir ◽  
Amy D. Anderson ◽  
Amanda B. Hepler
Keyword(s):  
Genetic Relatedness ◽  
Relatedness Analysis ◽  
New Challenges

The genetic relatedness analysis of male sterile and their maintainer lines of onion (Allium cepa L.) by using RAPD primers

2013 ◽  
Vol 16 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Dhanya Shivnanajappa ◽  
Lakshmana Reddy Dhoranalapalli Chinnappareddy ◽  
Verre Gowda ◽  
Sreedhara Sindughatta Antharamiah ◽  
Aswath Chennareddy
Keyword(s):  
Allium Cepa ◽  
Genetic Relatedness ◽  
Male Sterile ◽  
Allium Cepa L ◽  
Relatedness Analysis

scholarly journals Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

2020 ◽  
Author(s):  
Rachel F. Daniels ◽  
Stephen F. Schaffner ◽  
Yakou Dieye ◽  
Gnagna Dieng ◽  
Michael Hainsworth ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Imported Malaria ◽  
Intervention Selection ◽  
Optimal Intervention ◽  
Relatedness Analysis ◽  
Molecular Barcode ◽  
Gates Foundation ◽  
Low Prevalence ◽  
Imported Infections ◽  
Local Transmission

Abstract Background: Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.Methods: We applied a genetic strategy to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal.Results: Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travelers compared to travelers.Conclusions: These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement. This work was supported by the Bill & Melinda Gates Foundation, Grant Number OPP1156051

scholarly journals Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

2020 ◽  
Author(s):  
Sarah K. Volkman ◽  
Oumar Sarr ◽  
Richard W. Steketee ◽  
Stephen F. Schaffner ◽  
Yakou Dieye ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Imported Malaria ◽  
Travel History ◽  
Intervention Selection ◽  
Optimal Intervention ◽  
Relatedness Analysis ◽  
Molecular Barcode ◽  
Low Prevalence ◽  
Imported Infections ◽  
Local Transmission

Abstract Background Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history. Methods A genetic strategy was applied to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal. Results Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travellers compared to travellers. Conclusions These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement.

scholarly journals Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Wesley Wong ◽  
Allison D. Griggs ◽  
Rachel F. Daniels ◽  
Stephen F. Schaffner ◽  
Daouda Ndiaye ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Genetic Relatedness ◽  
Relatedness Analysis

scholarly journals Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

2020 ◽  
Author(s):  
Sarah K. Volkman ◽  
Oumar Sarr ◽  
Richard W. Steketee ◽  
Stephen F. Schaffner ◽  
Yakou Dieye ◽  
...  
Keyword(s):  
Genetic Relatedness ◽  
Imported Malaria ◽  
Travel History ◽  
Intervention Selection ◽  
Optimal Intervention ◽  
Relatedness Analysis ◽  
Molecular Barcode ◽  
Low Prevalence ◽  
Imported Infections ◽  
Local Transmission

Abstract Background: Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history. Methods: We applied a genetic strategy to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal. Results: Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travelers compared to travelers. Conclusions: These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement.

scholarly journals Application of DNA Fingerprints for Identification and Genetic Analyses of Mango (Mangifera indica) Genotypes

1995 ◽  
Vol 120 (2) ◽  
pp. 259-264 ◽  
Author(s):  
A. Adato ◽  
D. Sharon ◽  
U. Lavi ◽  
J. Hillel ◽  
S. Gazit
Keyword(s):  
Genetic Analysis ◽  
Genomic Dna ◽  
Genetic Relatedness ◽  
Mangifera Indica ◽  
Genetic Distances ◽  
Dna Fingerprint ◽  
Dna Fingerprints ◽  
Genetic Analyses ◽  
Young Leaves ◽  
Relatedness Analysis

DNA fingerprint information was used for identification of mango (Mangifera indica L.) cultivars for genetic relatedness analysis of20 mango cultivars and for genetic analysis of a family structure. Genomic DNA was extracted from young leaves, digested with Hind III or Dra I, and hybridized with 10 different DNA probes. Jeffreys' minisatellite probe 33.6 was the most useful, resulting in well-resolved bands representing highly polymorphic loci. Specific patterns were obtained for each cultivar. The probability of obtaining a similar pattern for two different cultivars was 9.4 × 10-6. Based on DNA fingerprint information, genetic distances between 20 mango cultivars were evaluated and an evolutionary tree was established. Analysis of DNA fingerprint band patterns of 12 progeny resulting from a cross between `Tommy Atkins' and `Keitt' mango revealed neither linked nor allelic bands. Application of the reported results for identification, genetic analyses, and mango breeding is discussed.

scholarly journals Spread of Extended-Spectrum β-Lactamase CTX-M-Producing Escherichia coli Clinical Isolates in Community and Nosocomial Environments in Portugal

2007 ◽  
Vol 51 (6) ◽  
pp. 1946-1955 ◽  
Author(s):  
Nuno Mendonça ◽  
Joana Leitão ◽  
Vera Manageiro ◽  
Eugénia Ferreira ◽  
Manuela Caniça
Keyword(s):  
Escherichia Coli ◽  
Genetic Relatedness ◽  
Therapeutic Option ◽  
E Coli ◽  
Extended Spectrum ◽  
Hospital Environments ◽  
Relatedness Analysis ◽  
Severe Infections ◽  
Tract Infections ◽  
M 14

ABSTRACT Of the 181 unduplicated Escherichia coli strains isolated in nine different hospitals in three Portuguese regions, 119 were extended-spectrum β-lactamase (ESBL)-CTX-M producers and were selected for phenotype and genotype characterization. CTX-M producer strains were prevalent among community-acquired infections (56%), urinary tract infections (76%), and patients ≥60 years old (76%). In MIC tests, all strains were resistant to cefotaxime, 92% were resistant to ceftazidime, 93% were resistant to quinolones, 89% were resistant to aminoglycoside, and 26% were resistant to trimethoprim-sulfamethoxazole; all strains were sensitive to carbapenems, and 92% of the strains had a multidrug resistance phenotype. Molecular methods identified 109 isolates harboring a bla CTX-M-15 gene, 1 harboring the bla CTX-M-32 gene (first identification in the country), and 9 harboring the bla CTX-M-14 gene. All isolates presented the ISEcp1 element upstream from the bla CTX-M genes; one presented the IS903 element (downstream of bla CTX-M-14 gene), and none had the IS26 element; 85% carried bla TEM-1B, and 84% also carried a bla OXA-30. Genetic relatedness analysis based on pulsed-field gel electrophoresis defined five clusters and indicated that 76% of all isolates (from cluster IV) corresponded to a single epidemic strain. Of the 47 strains from one hospital, 41 belonged to cluster IV and were disseminated in three main wards. CTX-M-producing E. coli strains are currently a problem in Portugal, with CTX-M-15 particularly common. This study suggests that the horizontal transfer of bla CTX-M genes, mediated by plasmids and/or mobile elements, contributes to the dissemination of CTX-M enzymes to community and hospital environments. The use of extended-spectrum cephalosporins, quinolones, and aminoglycosides is compromised, leaving carbapenems as the therapeutic option for severe infections caused by ESBL producers.

Genetic relatedness analysis of Nocardia strains by random amplification polymorphic DNA: validation and applications

2000 ◽  
Vol 151 (4) ◽  
pp. 263-270 ◽  
Author(s):  
Frédéric Laurent ◽  
Frédérique Provost ◽  
Andrée Couble ◽  
Emmanuelle Casoli ◽  
Patrick Boiron
Keyword(s):  
Genetic Relatedness ◽  
Random Amplification ◽  
Relatedness Analysis
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