scholarly journals Author Correction: A human-specific modifier of cortical connectivity and circuit function

Nature ◽  
2022 ◽  
Author(s):  
Ewoud R. E. Schmidt ◽  
Hanzhi T. Zhao ◽  
Jung M. Park ◽  
Mario Dipoppa ◽  
Mauro M. Monsalve-Mercado ◽  
...  
Keyword(s):  
Cortical Connectivity ◽  
Circuit Function ◽  
Human Specific

A human-specific modifier of cortical connectivity and circuit function

Nature ◽  
2021 ◽  
Author(s):  
Ewoud R. E. Schmidt ◽  
Hanzhi T. Zhao ◽  
Jung M. Park ◽  
Mario Dipoppa ◽  
Mauro M. Monsalve-Mercado ◽  
...  
Keyword(s):  
Cortical Connectivity ◽  
Circuit Function ◽  
Human Specific

scholarly journals A human-specific modifier of cortical circuit connectivity and function improves behavioral performance

2019 ◽  
Author(s):  
Ewoud R.E. Schmidt ◽  
Hanzhi T. Zhao ◽  
Jung M. Park ◽  
Jacob B. Dahan ◽  
Chris C. Rodgers ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Brain Evolution ◽  
Specific Gene ◽  
Behavioral Performance ◽  
Cortical Connectivity ◽  
Cortical Circuit ◽  
And Function ◽  
Circuit Function ◽  
And Behavior ◽  
Human Specific

SUMMARYThe remarkable cognitive abilities characterizing humans are thought to emerge from our unique features of cortical circuit architecture, including increased feedforward and feedback connectivity. However, our understanding of the evolutionary origin and nature of these changes in circuit connectivity, and how they impact cortical circuit function and behavior is currently lacking. Here, we demonstrate that expression of the human-specific gene duplication SRGAP2C leads to a specific increase in feedforward and feedback cortico-cortical connectivity. Moreover, humanized SRGAP2C mice display improved cortical sensory coding, and an enhanced ability to learn a cortex-dependent sensory discrimination task. Our results identify a novel substrate for human brain evolution whereby the emergence of SRGAP2C led to increased feedforward and feedback cortico-cortical connectivity, improved cortical sensory processing and enhanced behavioral performance.

Microfabrication research at the National Submicron Facility

1983 ◽  
Vol 41 ◽  
pp. 86-89
Author(s):  
E.D. Wolf
Keyword(s):  
Integrated Circuits ◽  
Particle Physics ◽  
High Speed ◽  
New Technology ◽  
High Energy ◽  
High Energy Particle ◽  
New Science ◽  
Wide Range ◽  
Intermediate Domain ◽  
Circuit Function

Most microelectronics devices and circuits operate faster, consume less power, execute more functions and cost less per circuit function when the feature-sizes internal to the devices and circuits are made smaller. This is part of the stimulus for the Very High-Speed Integrated Circuits (VHSIC) program. There is also a need for smaller, more sensitive sensors in a wide range of disciplines that includes electrochemistry, neurophysiology and ultra-high pressure solid state research. There is often fundamental new science (and sometimes new technology) to be revealed (and used) when a basic parameter such as size is extended to new dimensions, as is evident at the two extremes of smallness and largeness, high energy particle physics and cosmology, respectively. However, there is also a very important intermediate domain of size that spans from the diameter of a small cluster of atoms up to near one micrometer which may also have just as profound effects on society as “big” physics.

Moving Hands or Moving Feet: Cortical Connectivity during isolated limb movements

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
C Grefkes ◽  
AS Sarfeld ◽  
EM Pool ◽  
SB Eickhoff ◽  
GR Fink
Keyword(s):  
Limb Movements ◽  
Cortical Connectivity
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