scholarly journals Soluble adenylyl cyclase links Ca2+ entry to Ca2+/cAMP-response element binding protein (CREB) activation in vascular smooth muscle

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tony Parker ◽  
Kai-Wen Wang ◽  
Declan Manning ◽  
Caroline Dart
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Adenylyl Cyclase ◽  
Binding Protein ◽  
Camp Response Element Binding ◽  
Camp Response Element ◽  
Response Element ◽  
Soluble Adenylyl Cyclase ◽  
Creb Activation ◽  
Element Binding Protein

scholarly journals Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain

2004 ◽  
Vol 164 (4) ◽  
pp. 527-534 ◽  
Author(s):  
Jonathan H. Zippin ◽  
Jeanne Farrell ◽  
David Huron ◽  
Margarita Kamenetsky ◽  
Kenneth C. Hess ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Nuclear Protein ◽  
Camp Response Element Binding ◽  
Camp Response Element ◽  
Soluble Adenylyl Cyclase ◽  
Creb Activation ◽  
Alternate Pathway ◽  
Camp Pathway ◽  
Element Binding Protein ◽  
Kinase A

Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.

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