scholarly journals Longevity strategies in response to light in the reef coral Stylophora pistillata

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alexandre Ottaviani ◽  
Rita Eid ◽  
Didier Zoccola ◽  
Mélanie Pousse ◽  
Jean-Marc Dubal ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Nuclear Translocation ◽  
Human Fibroblasts ◽  
Reef Coral ◽  
Biological Response ◽  
Skin Aging ◽  
Stylophora Pistillata ◽  
Reef Corals ◽  
Effective Interventions ◽  
Age Related

AbstractAging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic stress is a key driver of cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic and hypoxic transitions, we hypothesized that these long-lived animals have developed specific longevity strategies in response to light. We analyzed transcriptome variation in the reef coral Stylophora pistillata during the day–night cycle and revealed a signature of the FoxO longevity pathway. We confirmed this pathway by immunofluorescence using antibodies against coral FoxO to demonstrate its nuclear translocation. Through qPCR analysis of nycthemeral variations of candidate genes under different light regimens, we found that, among genes that were specifically up- or downregulated upon exposure to light, human orthologs of two “light-up” genes (HEY1 and LONF3) exhibited anti-senescence properties in primary human fibroblasts. Therefore, these genes are interesting candidates for counteracting skin aging. We propose a large screen for other light-up genes and an investigation of the biological response of reef corals to light (e.g., metabolic switching) to elucidate these processes and identify effective interventions for promoting healthy aging in humans.

Prevalence of low bone mass and osteoporosis in patients with cancer: Program for healthy aging.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 30-30
Author(s):  
Beatrice Jara-Almonte Edwards ◽  
Ming Sun ◽  
Holly Michelle Holmes ◽  
Heather Valladarez ◽  
Vu Nguyen ◽  
...  
Keyword(s):  
Bone Mass ◽  
Healthy Aging ◽  
Negative Impact ◽  
Cohort Analysis ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Effective Interventions ◽  
Age Related ◽  
Md Anderson ◽  
Risk Factors For Falls

30 Background: Older adults, 65 years of age and older, with cancer may be at higher risk for low bone mass or osteoporosis, however, the exact magnitude of this condition is unknown. It is postulated that the etiology of low bone mass and osteoporosis in cancer may be a combination of age-related and cancer therapy related bone loss. Methods: We conducted a retrospective cohort analysis, of older adult cancer patients evaluated at the Program for Healthy Aging at MD Anderson from January 1, 2013 through March 31, 2015. Bone mineral density (BMD) was assessed with a Hologic W densitometer, with a CV% of 1%. Information on prior fractures and falls were also collected. Results: One hundred and nine patients with Bone density tests were included in the analysis, with males (n = 57) constituting 52% of cases, the mean age was 77 years, range 65 – 93 years. Race: white (n = 79, 74.5%), African- American (n = 23, 21.2%), Asian (n = 4, 3.8%). Ethnicity: Latino (n = 8, 11.4%). Cases included hematologic cancers (n = 41, 37.6%), breast cancer (n = 19, 17.4%), prostate cancer (n = 15, 13.8%), gastrointestinal cancers (n = 10, 9.2%), and bladder and lung cancer each (n = 6, 5.5%). Low bone mass and osteoporosis was identified in 87 cases (80%). Only 26 cases reported falls in the preceding 6 months, while 11 cases had a prior fracture after the age of 50 years. Additional risk factors for falls and fractures included cognitive impairment, malnutrition, and polypharmacy. Conclusions: Low bone mass and osteoporosis are highly prevalent conditions in older patients with hematologic and solid malignancies. A greater awareness of such, should allow for effective interventions in order to prevent fractures and their negative impact on quality of life.

scholarly journals Peroxisome Senescence in Human Fibroblasts

2002 ◽  
Vol 13 (12) ◽  
pp. 4243-4255 ◽  
Author(s):  
Julie E. Legakis ◽  
Jay I. Koepke ◽  
Chris Jedeszko ◽  
Ferdous Barlaskar ◽  
Laura J. Terlecky ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Protein Import ◽  
Human Fibroblasts ◽  
Toxic Metabolite ◽  
Age Related ◽  
Peroxisomal Targeting ◽  
Targeting Signal ◽  
Effects Of Aging ◽  
Antioxidant Enzyme Catalase ◽  
Import Receptor

The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. In this report, we characterize age-related changes in peroxisomes of human cells. We show that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, affecting in particular the critical antioxidant enzyme catalase. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite hydrogen peroxide, and we present evidence that this increased load of reactive oxygen species may further reduce peroxisomal protein import and exacerbate the effects of aging.

scholarly journals Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Ting Zhao ◽  
Shengfan Ye ◽  
Zimu Tang ◽  
Liwei Guo ◽  
Zhipeng Ma ◽  
...  
Keyword(s):  
Replicative Senescence ◽  
Brain Aging ◽  
Ventricular Zone ◽  
Human Fibroblasts ◽  
Cell Lineage ◽  
Lineage Tracing ◽  
Dependent Manner ◽  
Loss Of Function ◽  
Antioxidant Genes ◽  
Age Related

AbstractReactive oxygen species (ROS) stress has been demonstrated as potentially critical for induction and maintenance of cellular senescence, and been considered as a contributing factor in aging and in various neurological disorders including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). In response to low-level ROS stress, the expression of Δ133p53, a human p53 isoform, is upregulated to promote cell survival and protect cells from senescence by enhancing the expression of antioxidant genes. In normal conditions, the basal expression of Δ133p53 prevents human fibroblasts, T lymphocytes, and astrocytes from replicative senescence. It has been also found that brain tissues from AD and ALS patients showed decreased Δ133p53 expression. However, it is uncharacterized if Δ133p53 plays a role in brain aging. Here, we report that zebrafish Δ113p53, an ortholog of human Δ133p53, mainly expressed in some of the radial glial cells along the telencephalon ventricular zone in a full-length p53-dependent manner. EDU-labeling and cell lineage tracing showed that Δ113p53-positive cells underwent cell proliferation to contribute to the neuron renewal process. Importantly, Δ113p53M/M mutant telencephalon possessed less proliferation cells and more senescent cells compared to wild-type (WT) zebrafish telencephalon since 9-months old, which was associated with decreased antioxidant genes expression and increased level of ROS in the mutant telencephalon. More interestingly, unlike the mutant fish at 5-months old with cognition ability, Δ113p53M/M zebrafish, but not WT zebrafish, lost their learning and memory ability at 19-months old. The results demonstrate that Δ113p53 protects the brain from aging by its antioxidant function. Our finding provides evidence at the organism level to show that depletion of Δ113p53/Δ133p53 may result in long-term ROS stress, and finally lead to age-related diseases, such as AD and ALS in humans.

scholarly journals Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging Features of Various Plants of the Greek Flora

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1206
Author(s):  
Aimilia D. Sklirou ◽  
Maria T. Angelopoulou ◽  
Aikaterini Argyropoulou ◽  
Eliza Chaita ◽  
Vasiliki Ioanna Boka ◽  
...  
Keyword(s):  
Plant Species ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Ultra Performance Liquid Chromatography ◽  
Skin Aging ◽  
Rosa Damascena ◽  
Phytochemical Study ◽  
Age Related

Skin health is heavily affected by ultraviolet irradiation from the sun. In addition, senile skin is characterized by major changes in the collagen, elastin and in the hyaluronan content. Natural products (NPs) have been shown to delay cellular senescence or in vivo aging by regulating age-related signaling pathways. Moreover, NPs are a preferable source of photoprotective agents and have been proven to be useful against the undesirable skin hyperpigmentation. Greek flora harvests great plant diversity with approximately 6000 plant species, as it has a wealth of NPs. Here, we report an extensive screening among hundreds of plant species. More than 440 plant species and subspecies were selected and evaluated. The extracts were screened for their antioxidant and anti-melanogenic properties, while the most promising were further subjected to various in vitro and cell-based assays related to skin aging. In parallel, their chemical profile was analyzed with High-Performance Thin-Layer Chromatography (HPTLC) and/or Ultra-Performance Liquid Chromatography High-Resolution Mass Spectrometry (UPLC-HRMS). A variety of extracts were identified that can be of great value for the cosmetic industry, since they combine antioxidant, photoprotective, anti-melanogenic and anti-aging properties. In particular, the methanolic extracts of Sideritis scardica and Rosa damascena could be worthy of further attention, since they showed interesting chemical profiles and promising properties against specific targets involved in skin aging.

scholarly journals Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manjot Kaur Grewal ◽  
Shruti Chandra ◽  
Alan Bird ◽  
Glen Jeffery ◽  
Sobha Sivaprasad
Keyword(s):  
Macular Degeneration ◽  
Healthy Aging ◽  
Intraclass Correlation ◽  
Age Related Macular Degeneration ◽  
Healthy Individuals ◽  
Age Related ◽  
Rod Function ◽  
The Mean ◽  
Highly Correlated ◽  
Effect Of Age

AbstractTo evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman rs = 0.75–0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.

scholarly journals Age-Related Nuclear Translocation of P2X6 Subunit Modifies Splicing Activity Interacting with Splicing Factor 3A1

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123121 ◽  
Author(s):  
Juan Ignacio Díaz-Hernández ◽  
Álvaro Sebastián-Serrano ◽  
Rosa Gómez-Villafuertes ◽  
Miguel Díaz-Hernández ◽  
María Teresa Miras-Portugal
Keyword(s):  
Nuclear Translocation ◽  
Splicing Factor ◽  
Age Related

scholarly journals Nutrition for Older Athletes: Focus on Sex-Differences

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1409
Author(s):  
Barbara Strasser ◽  
Dominik Pesta ◽  
Jörn Rittweger ◽  
Johannes Burtscher ◽  
Martin Burtscher
Keyword(s):  
Sex Differences ◽  
Exercise Training ◽  
Role Model ◽  
Healthy Aging ◽  
Endurance Performance ◽  
Metabolic Efficiency ◽  
Older Athletes ◽  
Age Related ◽  
Masters Athletes ◽  
Physical Capacities

Regular physical exercise and a healthy diet are major determinants of a healthy lifespan. Although aging is associated with declining endurance performance and muscle function, these components can favorably be modified by regular physical activity and especially by exercise training at all ages in both sexes. In addition, age-related changes in body composition and metabolism, which affect even highly trained masters athletes, can in part be compensated for by higher exercise metabolic efficiency in active individuals. Accordingly, masters athletes are often considered as a role model for healthy aging and their physical capacities are an impressive example of what is possible in aging individuals. In the present review, we first discuss physiological changes, performance and trainability of older athletes with a focus on sex differences. Second, we describe the most important hormonal alterations occurring during aging pertaining regulation of appetite, glucose homeostasis and energy expenditure and the modulatory role of exercise training. The third part highlights nutritional aspects that may support health and physical performance for older athletes. Key nutrition-related concerns include the need for adequate energy and protein intake for preventing low bone and muscle mass and a higher demand for specific nutrients (e.g., vitamin D and probiotics) that may reduce the infection burden in masters athletes. Fourth, we present important research findings on the association between exercise, nutrition and the microbiota, which represents a rapidly developing field in sports nutrition.

A metabolomic aging clock using human CSF

2021 ◽  
Author(s):  
Nathan Hwangbo ◽  
Xinyu Zhang ◽  
Daniel Raftery ◽  
Haiwei Gu ◽  
Shu-Ching Hu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Healthy Aging ◽  
Prediction Models ◽  
Mass Spectrometry Analysis ◽  
Chronological Age ◽  
Healthy Human ◽  
Missing Data Imputation ◽  
Spectrometry Analysis ◽  
Residual Variation ◽  
Age Related

Abstract Quantifying the physiology of aging is essential for improving our understanding of age-related disease and the heterogeneity of healthy aging. Recent studies have shown that in regression models using “-omic” platforms to predict chronological age, residual variation in predicted age is correlated with health outcomes, and suggest that these “omic clocks” provide measures of biological age. This paper presents predictive models for age using metabolomic profiles of cerebrospinal fluid from healthy human subjects, and finds that metabolite and lipid data are generally able to predict chronological age within 10 years. We use these models to predict the age of a cohort of subjects with Alzheimer’s and Parkinson’s disease and find an increase in prediction error, potentially indicating that the relationship between the metabolome and chronological age differs with these diseases. However, evidence is not found to support the hypothesis that our models will consistently over-predict the age of these subjects. In our analysis of control subjects, we find the carnitine shuttle, sucrose, biopterin, vitamin E metabolism, tryptophan, and tyrosine to be the most associated with age. We showcase the potential usefulness of age prediction models in a small dataset (n = 85), and discuss techniques for drift correction, missing data imputation, and regularized regression, which can be used to help mitigate the statistical challenges that commonly arise in this setting. To our knowledge, this work presents the first multivariate predictive metabolomic and lipidomic models for age using mass spectrometry analysis of cerebrospinal fluid.

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