scholarly journals Therapeutic outcome of active management in male patients with detrusor underactivity based on clinical diagnosis and videourodynamic classification

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Cheng-Ling Lee ◽  
Jia-Fong Jhang ◽  
Han-Chen Ho ◽  
Yuan-Hong Jiang ◽  
Yuan-Hsiang Hsu ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Clinical Diagnosis ◽  
Successful Treatment ◽  
Therapeutic Outcome ◽  
Active Management ◽  
Treatment Modalities ◽  
Detrusor Underactivity ◽  
Successful Treatment Outcome ◽  
Detrusor Contractility ◽  
Bladder Sensation

AbstractDetrusor underactivity (DU) could be resulted from many different etiologies. Patients with DU might have reduced bladder sensation, low detrusor contractility, and large post-void residual volume. This study analyzed therapeutic outcome of active management for male DU patients, based on clinical and urodynamic characteristics. Male DU patients aged > 18 years old were retrospectively reviewed from the videourodynamic study (VUDS) records in recent 10 years. The patients’ demographics, VUDS results, treatment modalities, and treatment outcome were analyzed. The treatment outcomes were compared among patients with different DU subgroups, clinical diagnosis and treatment modalities. Patients with voiding efficiency of > 66.7% were considered having a successful treatment outcome. For comparison, 30 men with normal VUDS finding served as the control arm. Most of the DU patients had reduced bladder sensation. The reduced bladder sensation is closely associated with low detrusor contractility. After active treatment, a successful outcome was achieved in 68.4% of patients after bladder outlet surgery, 59.1% after urethral botulinum toxin A injection, and 57.6% after medical treatment, but only 18.2% after conservative treatment. A successful treatment outcome was achieved in patients with an intact detrusor contractility, either low (69.2%) or normal voiding pressure (81.8%), and in patients with a normal or increased bladder sensation (78.1%). However, patients with detrusor acontractile (41.3%) or absent bladder sensation (17.9%) had less favorable treatment outcome after any kind of urological management. This study revealed that active management can effectively improve voiding efficiency in patients with DU. The normal bladder sensation, presence of adequate detrusor contractility, and bladder outlet narrowing during VUDS provide effective treatment strategy for DU patients. Among all management, BOO surgery provides the best treatment outcome.

T-29 Early NK cell activation predicts successful treatment outcome in chronic HCV infection

2011 ◽  
Vol 43 ◽  
pp. S86 ◽  
Author(s):  
B. Oliviero ◽  
D. Mele ◽  
E. Degasperi ◽  
E. Cremonesi ◽  
S. Varchetta ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Successful Treatment ◽  
Cell Activation ◽  
Nk Cell ◽  
Hcv Infection ◽  
Successful Treatment Outcome ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals APPLICATIONS OF NANOTECHNOLOGY IN INTERDISCIPLINARY DENTISTRY

2020 ◽  
pp. 70-72
Author(s):  
Keerthivasan Arumugam ◽  
Vidhya Sampath ◽  
Rajkumar Kothandaraman ◽  
Mahalaxmi Sekar
Keyword(s):  
Treatment Outcome ◽  
Successful Treatment ◽  
Review Article ◽  
Successful Treatment Outcome ◽  
Interdisciplinary Dentistry

Nanotechnology has brought revolutionary changes in the fields of medicine and dentistry. The application of nanoparticles in dentistry is termed as nanodentistry. Researchers worldwide experiment and employ suitable nanoparticles to overcome the existing drawbacks associated with various materials and techniques used in dentistry. Dentistry is finely segregated into various disciplines, yet still closely interwoven and interdependent to achieve a successful treatment outcome. This approach forms the backbone of interdisciplinary dentistry. From combating infections caused by microbes to improving anchorage of implants, nanotechnology and nanomaterials find multitude of use in interdisciplinary dentistry. This review article summaries the plethora of nanoparticles and their application in interdisciplinary dentistry.

scholarly journals Childhood Tuberculosis Treatment Outcome and Its Association with HIV-Co infection in Ethiopia, A Systematic Review and Meta-analysis

2019 ◽  
Author(s):  
Getaneh Mulualem Belay ◽  
Chalachew Adugna Wubneh
Keyword(s):  
Systematic Review ◽  
Treatment Outcome ◽  
Successful Treatment ◽  
Meta Analysis ◽  
Tuberculosis Treatment ◽  
World Health ◽  
Successful Treatment Outcome ◽  
Poor Treatment ◽  
Poor Treatment Outcome ◽  
Tuberculosis Treatment Outcome

Abstract Introduction Globally around one million children are infected with Tuberculosis. Childhood Tuberculosis is underestimated due diagnosis challenge. HIV infection can affect the TB disease progression and treatment outcome.Objectives The aim of this systematic review and meta-analysis is to determine the pooled estimates of childhood tuberculosis treatment outcome and to analyze the impact of HIV-co infection.Methods We searched all available articles using PubMed, Google scholar and a web of science. Additionally, reference lists of included studies and Ethiopian institutional research repositories were used. Searching was limited to studies conducted in Ethiopia and published in English language. Cohort, cross-sectional and case-control studies were included. A weighted inverse variance random effects- model was used. The overall variations between studies were checked by heterogeneity test Higgins’s method (I 2 ). All included studies were assessed with the JBI quality appraisal criteria. Publication bias was checked with the funnel plot and Egger’s regression test.Result A total of 6 studies with 5,389 participants were included in this systematic review and meta-analysis. The overall pooled estimate of successful treatment outcome was found to be 79.54% (95% CI: 73.00, 86.07). Of which 72.44% were treatment completed. Moreover, this study revealed that the treatment failure, defaulter and death were 0.15%, 5.36%, and 3.54%, respectively. Poor treatment outcome was higher among children with HIV co infection with an odds ratio of 3.15 (95% CI: 1.67, 5.94) as compared to HIV negative children.Conclusion The rate of successful treatment outcome of childhood tuberculosis in Ethiopia found to be low compared to the threshold suggested by the world health organization. HIV co infection is significantly associated with poor treatment outcome. Therefore, special attention better to be given for children infected with HIV.

scholarly journals Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Sadick Ahmed Agyare ◽  
Francis Adjei Osei ◽  
Samuel Frimpong Odoom ◽  
Nicholas Karikari Mensah ◽  
Ernest Amanor ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Successful Treatment ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Directly Observed Therapy ◽  
Active Monitoring ◽  
Successful Treatment Outcome ◽  
Unsuccessful Treatment

Introduction. Tuberculosis poses a great threat to public health around the globe and affects persons mostly in their productive age, notwithstanding; everyone is susceptible to tuberculosis (TB) infection. To assess the effectiveness and performance of the tuberculosis control program activities, the percentage of cases with treatment success outcome is key. To control tuberculosis, interrupting transmission through effective treatment cannot be overemphasized. The study was conducted to determine factors associated with TB treatment outcome, in the Atwima Nwabiagya District from 2007–2017. Method. A Retrospective review of routine/standard TB registers was carried out in five directly observed therapy short-course (DOTS) centres at the Atwima Nwabiagya District from January 2007 to December 2017. Demographic characteristics, clinical characteristics, and treatment outcomes were assessed. Bivariate and multivariate logistic regression was conducted to determine the predictors of successful treatment outcome. Results. Of the 891 TB client’s data that was assessed in the district, the treatment success rate was 68.46%. Patients, aged ≤ 20 years (adjusted odds ratio aOR = 4.74 , 95 % CI = 1.75 − 12.83 ) and 51-60 years ( aOR = 1.94 , 95 % CI = 1.12 − 3.39 ), having a pretreatment weight of 35-45 kg ( aOR = 2.54 , 95 % CI = 1.32 − 4.87 ), 46-55 kg ( aOR = 2.75 , 95 % CI = 1.44 − 5.27 ) and 56-65 kg ( aOR = 3.04 , 95 % CI = 1.50 − 6.14 ) were associated with treatment success. However, retreatment patients ( aOR = 0.31 , 95 % CI = 0.11 − 0.84 ) resulted in unsuccessful treatment outcome. Conclusion. Successful treatment outcome among TB patients was about 20.00% and 30.00% lower compared to the national average treatment success rate and WHO target, respectively. Active monitoring, motivation, and counselling of retreatment patients and patients with advanced age are key to treatment success.

Aftershocks of Cancer Chemotherapy: Managing Adverse Effects

2007 ◽  
Vol 43 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Douglas H. Thamm ◽  
David M. Vail
Keyword(s):  
Treatment Outcome ◽  
Adverse Effects ◽  
Adverse Events ◽  
Cancer Chemotherapy ◽  
Successful Treatment ◽  
Client Satisfaction ◽  
Cytotoxic Chemotherapy ◽  
Low Risk ◽  
Small Animals ◽  
Successful Treatment Outcome

Most cytotoxic chemotherapy protocols used in small animals are designed to have a low risk of adverse effects; however, adverse events can occasionally occur. Timely and appropriate management of adverse events greatly increases client satisfaction and the likelihood of a successful treatment outcome. This article presents guidelines for the management of chemotherapy-associated hematological and gastrointestinal disturbances, extravasation injury, and anaphylaxis.

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