scholarly journals Clinicopathologic characteristics and prognosis for male breast cancer compared to female breast cancer

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Nan Yao ◽  
Wenzai Shi ◽  
Tong Liu ◽  
Sarah Tan Siyin ◽  
Weiqi Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Competing Risks ◽  
Male Breast Cancer ◽  
Cox Regression ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Limited Information ◽  
Female Breast ◽  
Her 2

AbstractMale breast cancer (MBC) is rare. Due to limited information, MBC has always been understudied. We conducted a retrospective population-based cohort study using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. The clinical and biological features of female breast cancer (FBC) patients were compared with MBC patients. Cox regression models and competing risks analyses were used to identify risk factors associated with cancer-related survival in MBC and FBC groups. Results showed that MBC patients suffered from higher TNM stages, tumor grades, and a higher percentage of hormone receptor-positive tumors, compared with FBC patients (all p < 0.05). In addition, the breast tumor locations varied a lot between males and females (p < 0.05). FBC patients were associated with superior overall survival than MBC patients. Results from multivariate cox regression and competing risks analyses showed age, race, T, N, M-stages, tumor grades, estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) overexpression were independent prognosis factors in FBC patients (all p < 0.05). MBC patients had similar risk factors to FBC patients, but PR and HER-2 status did not independently influence survival (all p > 0.05). Tumor location was an independent prognostic factor for both gender groups.

scholarly journals Male breast cancer and female breast cancer: A population-based study

2021 ◽  
Author(s):  
Nan Yao ◽  
Wenzai Shi ◽  
Tong Liu ◽  
Sarah Tan Siyin ◽  
Weiqi Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Male Breast Cancer ◽  
Cox Regression ◽  
Population Based ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Risk Of Death ◽  
Female Breast ◽  
Kaplan Meier

Abstract Male breast cancer (MBC) is a rare disease. Due to limited information, MBC has always been understudied. We conducted a retrospective population-based cohort study by using the 2010–2014 Surveillance, Epidemiology, and End Results (SEER) program data. The clinical and biological features of female breast cancer (FBC) patients were compared with MBC patients. Survival curves were constructed with the Kaplan-Meier method. Multivariate Cox regression models and competitive risk models were separately built to identify factors associated with survival time in the MBC and FBC group. Our retrospective study showed that MBC patients suffered with higher TNM stages, higher grades, and more percent of hormone receptor–positive tumors, compared with FBC patients. In addition, the site of the primary breast cancer varied greatly different between genders. FBC patients demonstrated superior overall survival than MBC patients on Kaplan-Meier analysis. In multivariate COX analysis for FBC patients, older age, black race, higher T, N, M-stages, higher grades, estrogen receptor (ER)/progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative were associated with higher risk of death. MBC patients had similar independent prognostic factors, but PR and HER-2 status did not appear to independently influence survival. Interestingly, primary site location was an independent prognostic factor for both MBC patients and FBC patients, which should be considered by clinicians as a prognostic factor.

scholarly journals Assessment of Knowledge and Attitude Regarding Female and Male Breast Cancer among Adults of South India

2021 ◽  
pp. 13-20
Author(s):  
Anwitha Johns ◽  
Satish Kumar B P ◽  
Lavanya P R
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Incidence Rates ◽  
Male Breast ◽  
Basic Knowledge ◽  
Nominal Data ◽  
Female Breast ◽  
South Indian ◽  
Knowledge And Attitude

Background & Objectives: Breast cancer is the second leading reason for cancer death in women. Incidence rates of male breast cancer have increased by 0.2- 1% per year. The lack of knowledge and awareness of male breast cancer leads to its detection at a late stage in men. This study is to assess the knowledge and attitude of south Indian adults towards male and female breast cancer. Methods: To assess the knowledge and attitude of adults on breast cancer, a questionnaire regarding basic knowledge and attitudes was formulated using Google forms. Numbers and percentages were formed to review categorical and nominal data. Chi-square (χ2) test was used for the comparison between the awareness of female breast cancer and male breast cancer. P < 0.05 was set as the level of significance.

Is Male Breast Cancer Similar or Different than Female Breast Cancer?

2004 ◽  
Vol 83 (1) ◽  
pp. 77-86 ◽  
Author(s):  
William F. Anderson ◽  
Michelle D. Althuis ◽  
Louise A. Brinton ◽  
Susan S. Devesa
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Female Breast

Male breast cancer: Prognostic factors evaluation in a 35-year service

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11618-e11618
Author(s):  
R. D. Botan ◽  
M. N. Alvares ◽  
A. Hassan
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Prognostic Factors ◽  
Male Breast Cancer ◽  
Survival Curve ◽  
Local Treatment ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Breast Cancer Patients ◽  
Female Breast

e11618 Background: Treatment for male breast cancer is based on the results of large clinical trials for female breast cancer. Although peculiar differences do exist between men and women, very little is known about the prognostic factors in male breast cancer, even though female breast cancer practical conducts are widely used in male breast cancer. The rarity of this condition makes very difficult to produce randomized trials. Methods: This study is populational and epidemiological and evaluated male breast cancer patients from January 1974 to December 2001 about its prognostic characteristics. Data were collected retrospectively and the sample has been described using descriptive statistics methods. Survival curve was built using Kaplan-Meier method. Staging system was standardized as in the sixth edition of American Joint Committee on Cancer, independently on when the diagnose was made. Due to differences throughtout 35 years on therapeutic on breast cancer, treatment options were categorized in groups to make the survival evaluation possible. Results: From 45 patients with male breast cancer, 91% presented ductal histology, 26% were negative axillary, 9.1% were T1, 25% were T2, 4.5% were T3, 50% were T4 and 12.12% presented with distant metastasis at diagnose. Seventy nine percent were submitted to radical local treatment, while 34% had not been submitted to any kind of systemic treatment (neoadjuvant, adjuvant e hormone therapy). Forty percent of patients have not presented distant recurrence, while 58.3% have not presented local recurrence. A median survival of 126 months has been observed to the analyzed population, ranging from 69–182 months. Five-year survival was 72% and 10-year survival was 54%. These data agreed with the available data in the published literature. Conclusions: Male breast cancer appears to behave biologically and clinically very similar to female breast cancer, but differences do exist and need to be elucidated. Randomized multi-center clinical trials become necessary, as systematic reviews, to build higher statistic power studies. No significant financial relationships to disclose.

Examining racial disparities in male breast cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 6555-6555
Author(s):  
Elizabeth Shurell Linehan ◽  
Navendu D. Samant ◽  
Juleon W Rabbani
Keyword(s):  
Breast Cancer ◽  
Racial Disparities ◽  
Cancer Patients ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Breast Cancer Patients ◽  
Female Breast ◽  
Mean Time ◽  
Related Mortality

6555 Background: Male breast cancer (MBC) accounts for approximately 1% of all breast cancers. Racial disparities have not been examined in MBC. Methods: Within a large, integrated health delivery system, all adult female and male patients who were diagnosed with breast cancer from 01-01-2010 to 12-31-2018 were examined. Bivariate analysis was performed to examine clinical and demographic factors associated with breast cancer-related mortality. We conducted more detailed chart review in the MBC-only group (data period 01-01-2010 to 12-31-2019) to assess the mean time to treatment (from diagnosis to surgery, surgery to chemotherapy, and surgery to radiation) stratified by race using bivariate (t-test, one way ANOVA) analyses. Results: 32,848 female breast cancer and 226 MBC patients were evaluated; MBC patients represented 0.63% of all breast cancer patients. Between males and females, there was no statistically significant difference in race, with an overall distribution of 62% White, 19% Asian, 8% Black, and 11% Hispanic. To our knowledge, this is the largest and most racially diverse sample of MBC patients to date. MBC patients at diagnosis were significantly older (p <.0001), more obese (p < 0.0018), and sicker according to the Charlson Comorbidity Index (CCI) (p < 0.0001) compared to female breast cancer patients. Males were more likely to be diagnosed at an advanced stage (19.2%) compared to females (12.5%) (p = 0.0037). With a mean follow up of 5 years, overall mortality was statistically significantly worse in MBC (23.0%) compared to female breast cancer patients (12.0%) (p < 0.0001). Furthermore, breast cancer-related mortality was significantly higher in males (8.1%) than in females (4.5%) (p = 0.0124). In the MBC-only analysis, stage at diagnosis was not influenced by patient race. Asian and White MBC patients had the shortest mean time from diagnosis to surgery (27 and 29 days, respectively), with Hispanic MBC patients experiencing the longest time to surgery (46 days). Black MBC patients experienced the shortest mean time to chemotherapy after surgery (39 days), whereas Asian MBC patients experienced the longest time to chemotherapy (50 days). In survivorship, Black and Asian patients were least likely to undergo screening mammography (33.3%, and 43.3%, respectively), compared to 52% of White and 50% of Hispanic MBC patients. Ultimately, 13% of Asian and 11% of Hispanic MBC patients died of breast cancer, compared to 6.7% of Black and 6.2% of White MBC patients. Conclusions: While we found no statistically significant differences in mortality by race among MBC patients, our findings indicate that non-white patients had longer time to treatments, less survivorship screening, and worse disease related mortality than their white counterparts. Future study can elucidate these racial inequalities, enabling more equitable breast cancer treatment among patient subgroups.

scholarly journals PD-1 and PD-L1 Expression in Male Breast Cancer in Comparison with Female Breast Cancer

2018 ◽  
Vol 13 (6) ◽  
pp. 769-777 ◽  
Author(s):  
Quirine F. Manson ◽  
Natalie D. ter Hoeve ◽  
Horst Buerger ◽  
Cathy B. Moelans ◽  
Paul J. van Diest
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Female Breast

scholarly journals Male breast cancer: A retrospective study comparing survival with female breast cancer

2012 ◽  
Vol 4 (4) ◽  
pp. 642-646 ◽  
Author(s):  
LI BAOJIANG ◽  
LIU TINGTING ◽  
LI GANG ◽  
ZHANG LI
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Female Breast
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