scholarly journals First trimester pregnancy outcomes in a large IVF center from the Lombardy County (Italy) during the peak COVID-19 pandemic

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
P. E. Levi- Setti ◽  
F. Cirillo ◽  
V. Immediata ◽  
E. Morenghi ◽  
V. Canevisio ◽  
...  

AbstractAt the beginning of 2020, the Italian Lombardy region was hit by an “epidemic tsunami” which was, at that point in time, one of the worst pandemics ever. At that moment the effects of SARS-COV 2 were still unknown. To evaluate whether the pandemic has influenced ART (Assisted Reproduction Techniques) outcomes in an asymptomatic infertile population treated at one of the major COVID-19 epicentres during the weeks immediately preceding lockdown. All ART procedures performed during two time periods were compared: November 1st, 2018 to February 28th, 2019 (non-COVID-19 risk) and November 1st, 2019 to February 29th, 2020 (COVID-19 risk). In total 1749 fresh cycles (883 non-COVID-19 risk and 866 COVID-19 risk) and1166 embryos and 63 oocytes warming cycles (538 and 37 during non-COVID and 628 and 26 during COVID-19 risk, respectively) were analysed. Clinical pregnancies per cycle were not different: 370 (25.38%) in non-COVID versus 415 (27.30%) (p = 0.237) during COVID-19 risk. There were no differences in biochemical pregnancy rates 52 (3.57%) versus 38 (2.50%) (p = 0.089) nor in ectopic pregnancies 4 (1.08%) versus 3 (0.72%) (p = 0.594), spontaneous miscarriages 84 (22.70%) versus 103 (24.82%) p = 0.487, nor in intrauterine ongoing pregnancies 282 (76.22%) versus 309 (74.46%) p = 0.569. A multivariate analysis investigating differences in spontaneous miscarriage rate showed no differences between the two timeframes. Our results support no differences in asymptomatic infertile couples’ ART outcomes between the pre COVID and COVID-19 periods in one of the earliest and most severe pandemic areas.

2021 ◽  
Author(s):  
Paolo Emanuele Levi-Setti ◽  
Federico Cirillo ◽  
Valentina Immediata ◽  
Emanuela Morenghi ◽  
Valentina Canevisio ◽  
...  

Abstract This study evaluates if the pandemic has influenced ART outcome in an asymptomatic infertile population treated at one of the major COVID-19 epicenters during the weeks immediately preceding the lockdown. All ART procedures during two time periods were used for comparison: November 1st, 2018 to February 28th, 2019 (non COVID-19 risk) and November 1st, 2019 to February 29th, 2020 (COVID-19 risk). We analyzed 1,749 fresh cycles (883 non COVID-19 risk and 866 COVID- 19 risk), 1,166 embryo and 63 oocytes warming cycles (538 and 37 during non COVID and 628 and 26 during COVID-19 risk respectively). Clinical pregnancies per cycle were not different: 370 (25,38%) in non COVID vs 415 (27,30%) (p=0.237) during COVID-19 risk. There were no differences in biochemical pregnancy rates 52 (3,57%) vs 38 (2,50%) (p=0.089) nor in ectopic pregnancies 4 (1,08%) vs 3 (0,72%) (p=0,594), spontaneous abortions 84 (22,70%) vs 103 (24,82%) p=0,487, intrauterine ongoing pregnancies 282 (76,22%) vs 309 (74,46%) p=0.569. A multivariate analysis investigating differences in abortion rate showed no differences between the two times frame. Our results support no differences in asymptomatic infertile couples’ ART outcomes between pre COVID and COVID-19 period in one of early and most severe pandemic area.


2019 ◽  
Vol 1 (67) ◽  
pp. 13
Author(s):  
Carmen Elena Bucuri ◽  
Răzvan  Ciortea ◽  
Andrei Mihai Malutan ◽  
Cristian Iuhaș ◽  
Maria Rada ◽  
...  

Author(s):  
Torsten Schmidt ◽  
Daniel T. Rein ◽  
Dolores Foth ◽  
Hans-Walter Eibach ◽  
Christian M. Kurbacher ◽  
...  

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