scholarly journals Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Susana Merino-Caviedes ◽  
Lilian K. Gutierrez ◽  
José Manuel Alfonso-Almazán ◽  
Santiago Sanz-Estébanez ◽  
Lucilio Cordero-Grande ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy ◽  
Automatic Segmentation ◽  
Three Dimensional ◽  
Scar Assessment ◽  
Myocardial Substrate ◽  
Efficient Alternative ◽  
Translational Approach ◽  
Lge Cmr

AbstractDelayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.

scholarly journals Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
L K Gutierrez ◽  
S Merino-Caviedes ◽  
JM Alfonso-Almazan ◽  
S Sanz-Estebanez ◽  
L Cordero-Grande ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Translational Study ◽  
National Budget ◽  
Funding Sources ◽  
Scar Assessment ◽  
Public Grant ◽  
Lge Cmr

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): - Ministerio de Ciencia e Innovación and the ProCNIC Foundation - Grant TEC2017-82408-R Background  We aimed to validate a 3D methodology for transmural scar assessment using time-efficient upsampled models from 2D delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) sequences and determine the clinical implications in ischemic cardiomyopathy-related ventricular tachycardia (VT) episodes.  Methods  Translational study including 10 pigs with myocardial infarction and 15 patients with spontaneous VT episodes and underlying infarct-related scar. Pigs underwent 3D LGE-CMR sequences to test 3D transmural-based scar assessment using several downsampled resolutions from the original images. Validation in patients included 3D and 2D LGE-CMR studies performed within the same protocol. Transmural-based scar areas were used for correlation analyses with the cycle length (CL) of VT episodes. Scar volumes were used as a benchmark comparison.  Results  In pigs, 3D transmural-based scar areas showed interclass correlation coefficients >0.94 between original 3D high-resolution- and downsampled-derived models. In patients, scar area quantification in myocardial regions with 3D transmurality <0.2 (for upsampled 2D-derived models) and <0.1 (for 3D-derived models) showed direct correlation with the CL of spontaneous VT episodes (r = 0.69; p < 0.01 and r = 0.79; p < 0.01, respectively) (See Abstract Figure). After ablation, patients with VT recurrences showed lower scar areas on 3D and upsampled 2D models using <0.1 and <0.2 transmurality criteria, respectively, than patients without VT recurrences (48.5 [37.7, 67.5] vs. 91.5 [84.3, 117.3] cm2, respectively, for 3D-derived models; p = 0.004, and 64.0 [43.5, 69.5] vs. 83.0 [70.2, 99.7] cm2, respectively, for upsampled 2D models; p = 0.04). Conversely, time-consuming scar volume reconstructions from 2D or 3D LGE-CMR sequences did not show significant differences between patients with and without VT recurrences.   Conclusions  Three-dimensional transmural scar assessment in upsampled 2D-LGE-CMR-derived models provides time-efficient characterization of infarct-related myocardial substrates associated with the CL of spontaneous VT episodes and VT recurrences after ablation. Abstract Figure

Long-Term Outcomes of Inducible Very Fast Ventricular Tachycardia (Cycle Length 200-250 ms) in Patients With Ischemic Cardiomyopathy

2010 ◽  
Vol 21 (3) ◽  
pp. 262-269 ◽  
Author(s):  
SAURABH KUMAR ◽  
GOPAL SIVAGANGABALAN ◽  
MAN-CHUN CHOI ◽  
VICKI EIPPER ◽  
ARAVINDA THIAGALINGAM ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy ◽  
Cycle Length ◽  
Long Term Outcomes

scholarly journals B-PO01-068 LONG-TERM OUTCOME OF ENDOCARDIAL-ONLY VERSUS COMBINED ENDOCARDIAL-EPICARDIAL HOMOGENIZATION OF THE SCAR FOR TREATMENT OF VENTRICULAR TACHYCARDIA IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S78
Author(s):  
Andrea Natale ◽  
Sanghamitra Mohanty ◽  
Chintan G. Trivedi ◽  
Domenico G. Della Rocca ◽  
Carola Gianni ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Long-term outcome of surgical cryoablation for refractory ventricular tachycardia in patients with non-ischemic cardiomyopathy

EP Europace ◽  
2017 ◽  
Vol 20 (3) ◽  
pp. e30-e41 ◽  
Author(s):  
Jackson J Liang ◽  
Brian P Betensky ◽  
Daniele Muser ◽  
Erica S Zado ◽  
Elad Anter ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy ◽  
Term Outcome ◽  
Long Term Outcome

Epicardial ventricular tachycardia in ischemic cardiomyopathy: Prevalence, electrophysiological characteristics, and long‐term ablation outcomes

2018 ◽  
Vol 29 (11) ◽  
pp. 1530-1539 ◽  
Author(s):  
Tatsuya Hayashi ◽  
Jackson J. Liang ◽  
Daniele Muser ◽  
Yasuhiro Shirai ◽  
Andres Enriquez ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ischemic Cardiomyopathy

Practical electron tomography

1995 ◽  
Vol 53 ◽  
pp. 742-743
Author(s):  
C.L. Woodcock
Keyword(s):  
Electron Tomography ◽  
Tomographic Reconstruction ◽  
Three Dimensional ◽  
3D Shape ◽  
Computational Resources ◽  
Shape Of Particles

Despite the potential of the technique, electron tomography has yet to be widely used by biologists. This is in part related to the rather daunting list of equipment and expertise that are required. Thanks to continuing advances in theory and instrumentation, tomography is now more feasible for the non-specialist. One barrier that has essentially disappeared is the expense of computational resources. In view of this progress, it is time to give more attention to practical issues that need to be considered when embarking on a tomographic project. The following recommendations and comments are derived from experience gained during two long-term collaborative projects.Tomographic reconstruction results in a three dimensional description of an individual EM specimen, most commonly a section, and is therefore applicable to problems in which ultrastructural details within the thickness of the specimen are obscured in single micrographs. Information that can be recovered using tomography includes the 3D shape of particles, and the arrangement and dispostion of overlapping fibrous and membranous structures.

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