scholarly journals Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Javier de-Miguel-Diez ◽  
Marta Lopez-Herranz ◽  
Valentín Hernandez-Barrera ◽  
David Jimenez ◽  
Manuel Monreal ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Obstructive Sleep Apnea ◽  
Sex Differences ◽  
Sleep Apnea ◽  
Hospital Mortality ◽  
Hospital Admissions ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep ◽  
Discharge Database

AbstractWe determined sex differences in the prevalence of obstructive sleep apnea (OSA) among patients hospitalized with pulmonary embolism (PE) in Spain (2016–2018). We also compared outcomes according to the presence of OSA, and identified variables associated with in-hospital-mortality (IHM) after PE using the Spanish National Hospital Discharge Database. We identified 46,794 hospital admissions for PE; of these, 5.47% had OSA. OSA was more prevalent among men than women (7.57% vs. 3.65%, p < 0.001), as in the general population. Propensity score matching did not reveal differences in concomitant conditions or procedures between patients with and without OSA, except for the use of non-invasive ventilation, which was more frequent in patients with OSA. IHM was similar in patients with and without OSA (3.58% vs. 4.31% for men and 4.39% vs. 4.93% for women; p > 0.05). Older age, cancer, atrial fibrillation, non-septic shock, and need for mechanical ventilation increased IHM in men and women with OSA hospitalized with PE. The logistic regression model showed no sex differences in IHM among patients with OSA.

scholarly journals Copeptin, Pro-atrial Natriuretic Peptide and Pro-adrenomedullin as Markers of Hypoxic Stress in Patients With Obstructive Sleep Apnea - a Prospective Intervention Study

2021 ◽  
Author(s):  
Meropi Karakioulaki ◽  
Peter Grendelmeier ◽  
Werner Strobel ◽  
Thomas Schmid ◽  
Kathleen Jahn ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Therapy Response ◽  
Cpap Therapy ◽  
Non Invasive ◽  
Acute Response ◽  
Venous Puncture ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep

Abstract Study Objectives: Obstructive sleep apnea (OSA) might lead to oxidative stress, inflammation and elevated circulating copeptin, proANP and proADM levels. We aimed to evaluate whether the levels of these prohormones are higher in patients with OSA and whether they might change under continuous positive airway pressure (CPAP) therapy, serving as potential proxies for the diagnosis and therapy-response in OSA. Methods: A total of 310 patients with suspicion of OSA were recruited. Screening for OSA was performed using overnight pulse oximetry followed by polygraphy and a venous puncture in the morning. All patients diagnosed with OSA underwent CPAP adaptation. A venous puncture was conducted in the night before CPAP and in the following morning. At 1 and 6 months of treatment, polygraphy was performed, followed by a venous puncture in the morning. In the acquired blood, copeptin, proANP and proADM levels were measured.Results: We analyzed 232 patients with OSA and 30 patients without OSA. Our results indicated that only copeptin levels differed significantly among patients with and without OSA at baseline. In OSA patients, the levels of proADM significantly changed after 1 and 6 months on CPAP therapy, when compared to baseline (p<0.001 and p=0.020). Additionally, proANP levels significantly decreased after 12 hours on CPAP therapy, as compared to baseline levels (p<0.001). Conclusions: Copeptin is significantly associated with the presence of OSA. ProANP levels might serve as a potential proxy for the acute response to non-invasive ventilation (12 hours), while proADM reflects the long-term response (1 and 6 months).

scholarly journals Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea—a prospective intervention study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Meropi Karakioulaki ◽  
Peter Grendelmeier ◽  
Werner Strobel ◽  
Thomas Schmid ◽  
Kathleen Jahn ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Therapy Response ◽  
Cpap Therapy ◽  
Non Invasive ◽  
Acute Response ◽  
Venous Puncture ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep

Abstract Study Objectives Obstructive sleep apnea (OSA) might lead to oxidative stress, inflammation and elevated circulating copeptin, proANP and proADM levels. We aimed to evaluate whether the levels of these prohormones are higher in patients with OSA and whether they might change under continuous positive airway pressure (CPAP) therapy, serving as potential proxies for the diagnosis and therapy-response in OSA. Methods A total of 310 patients with suspicion of OSA were recruited. Screening for OSA was performed using overnight pulse oximetry followed by polygraphy and a venous puncture in the morning. All patients diagnosed with OSA underwent CPAP adaptation. A venous puncture was conducted in the night before CPAP and in the following morning. At 1 and 6 months of treatment, polygraphy was performed, followed by a venous puncture in the morning. In the acquired blood, copeptin, proANP and proADM levels were measured. Results We analyzed 232 patients with OSA and 30 patients without OSA. Our results indicated that only copeptin levels differed significantly among patients with and without OSA at baseline. In OSA patients, the levels of proADM significantly changed after 1 and 6 months on CPAP therapy, when compared to baseline (p < 0.001 and p = 0.020). Additionally, proANP levels significantly decreased after 12 h on CPAP therapy, as compared to baseline levels (p < 0.001). Conclusions Copeptin is significantly associated with the presence of OSA. ProANP levels might serve as a potential proxy for the acute response to non-invasive ventilation (12 h), while proADM reflects the long-term response (1 and 6 months).

scholarly journals The combination of atrial fibrillation and obstructive sleep apnea — is there a connection?

2018 ◽  
pp. 119-124 ◽  
Author(s):  
G. G. Arutyunyan ◽  
M. V. Agaltsov ◽  
K. V. Davtyan ◽  
O. M. Drapkina
Keyword(s):  
Atrial Fibrillation ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mutual Influence ◽  
Early Postoperative Period ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep ◽  
Ventilation Support

The review discusses the issue of the mutual influence of combination of atrial fibrillation (AF) and obstructive sleep apnea (OSA). In individuals with a combination of these pathologies, OSA can influence the easier realization of AF. The presence of respiratory disturbances in sleep reduces the effectiveness of all types of AF treatment (antiarrhythmic, surgical, electrical cardioversion). It is shown, that the treatment of OSA by the method of non-invasive ventilation support (CPAP-therapy) improves the results of catheter treatment of AF in the early postoperative period.

scholarly journals Sleep-related breathing disorders and non-invasive ventilation

2015 ◽  
Vol 9 (2) ◽  
pp. 109
Author(s):  
Agata Lax ◽  
Simona Colamartino ◽  
Paolo Banfi ◽  
Antonello Nicolini
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Neuromuscular Disorders ◽  
Invasive Mechanical Ventilation ◽  
Patient Acceptance ◽  
Invasive Ventilation ◽  
Respiratory Impairment ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep

Non-invasive mechanical ventilation (NPPV) was originally used in patients with acute respiratory impairment or exacerbations of chronic respiratory diseases, as an alternative to the endotracheal tube. Over the last thirty years NPPV has been also used at night in patients with stable chronic lung disease such as obstructive sleep apnea, the overlap syndrome (chronic obstructive pulmonary disease and obstructive sleep apnea), neuromuscular disorders, obesity-hypoventilation syndrome, and in other conditions such as sleep disorders associated with congestive heart failure (Cheyne-Stokes respiration). In this no-systematic review we discuss the different types of NPPV, the specific conditions in which they can be used and the indications, recommendations and evidence supporting the efficacy of NPPV. Optimizing patient acceptance and adherence to non-invasive ventilation treatment is challenging. The treatment of sleep-related disorders is a life-threatening condition. The optimal level of treatment should be determined in a sleep laboratory. Side effects directly affecting the patient’s adherence to treatment are known. The most common are nasopharyngeal symptoms including increased congestion and rhinorrhea; these effects are related to reduced humidity of inspired gas. Humidification of delivered gas may improve these symptoms.

Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients

2014 ◽  
Vol 19 (2) ◽  
pp. 623-630 ◽  
Author(s):  
Raffaele Antonelli Incalzi ◽  
Giorgio Pennazza ◽  
Simone Scarlata ◽  
Marco Santonico ◽  
Chiara Vernile ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Induced Changes

scholarly journals The opportunities of non-invasive ventilation in the treatment of drug-resistant hypertensive patients with obstructive sleep apnea syndrome

2012 ◽  
Vol 18 (2) ◽  
pp. 102-107
Author(s):  
Y. V. Sviryaev ◽  
N. E. Zvartau ◽  
L. S. Korostovtseva ◽  
A. O. Konradi
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Apnea Syndrome ◽  
Drug Resistant ◽  
Invasive Ventilation ◽  
Hypertensive Patients ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Obstructive Sleep ◽  
Apnea Syndrome

The article reviews the trials in hypertensive patients with obstructive sleep apnea syndrome (OSAS). The relation of arterial hypertension and OSAS and the underlying mechanisms, as well as the possible causes of drug-resistant hypertension are discussed. The results on the use of non-invasive ventilation (so called CPAP-therapy, continuous positive airway pressure) are presented.

Sign in / Sign up

Export Citation Format

Share Document