scholarly journals Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Noyan Hossain Molla ◽  
Rahanuma Raihanu Kathak ◽  
Abu Hasan Sumon ◽  
Zitu Barman ◽  
Ananya Dutta Mou ◽  
...  
Keyword(s):  
Uric Acid ◽  
General Population ◽  
Serum Uric Acid ◽  
Liver Enzymes ◽  
Multinomial Logistic Regression ◽  
Adult Population ◽  
Enzymes Activity ◽  
Significant Difference ◽  
The Mean ◽  
The Relationship

AbstractSerum uric acid (SUA) level has been suggested to be associated with cardiovascular disease, diabetes and metabolic syndrome. However, little is known about the relationship between SUA and liver enzymes activity in the general population. The present study aimed to assess the relationship between SUA and serum liver enzymes in an adult population in Bangladesh. In this cross-sectional study, a total of 410 blood samples were collected from apparently healthy adults aged > 18 years. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. Multinomial logistic regression model was used to assess the relationship between SUA and elevated levels of liver enzymes among the participants. Overall, the prevalence of hyperuricemia was 30.1% with 32.2% in male and 18.6% in female participants. About 33% of the participants had at least one or more elevated levels of liver enzymes. The mean level of SUA was significantly higher in males (389.3 ± 96.9 µmol/L) than in the female (290.4 ± 89.8 µmol/L) subjects (p < 0.001). There was a significant difference in the mean levels of serum ALT and GGT between the male (34.5 ± 16.0 U/L and 26.7 ± 19.5 U/L, respectively) and female (25.0 ± 13.0 U/L and 19.5 ± 13.2 U/L, respectively) participants (p < 0.001 and p < 0.01, respectively). An increasing trend was observed in the mean levels of serum ALT and GGT across the SUA quartile groups (p < 0.001 and p < 0.01, respectively). SUA showed a positive and significant correlation with serum ALT (p < 0.001) and GGT (p < 0.01). In further statistical analysis after adjustment for potential confounders, SUA showed an independent and significant association with serum ALT and GGT in all regression models. In conclusion, SUA was strongly associated with serum levels of ALT and GGT after adjustment for potential confounders. More prospective studies are needed to clarify the complex relationship between SUA and liver enzymes in the general population.

scholarly journals Correlations of complete blood count, liver enzyme and serum uric Acid in Sudanese pre-eclamptic cases

2018 ◽  
Vol 7 (4) ◽  
pp. 1308
Author(s):  
Hind M. Beheiry ◽  
Ibrahim A. Ali ◽  
Mazin S. Abdalla ◽  
Ahmed M. Sharif ◽  
Amal M. Saeed
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Liver Enzymes ◽  
Complete Blood Count ◽  
Maternity Hospital ◽  
Prognostic Indicators ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
Wbc Count

Background: Pre-eclampsia is a serious disorder of pregnancy with unknown ethological factors that may occur at any stage of second or third trimester of pregnancy. The objectives of the present study were to assess changes in complete blood counts including platelets, liver enzymes and serum uric acid in pre-eclamptic cases compared to second-half normal pregnant and non-pregnant Sudanese women and their correlations to other biomarkers.Methods: This was a cross-sectional, case-control study performed from December 2008 to December 2010; in Omdurman Maternity Hospital, in concomitance with other studies in pre-eclampsia. The sample size included three groups, 72 up pre-eclamptic cases in their recent pregnancies, 96 normal pregnant in their second half of pregnancy and 63 non- pregnant (control) women; a total of 231 subjects. Questionnaire Interviews and clinical examination were done for all participants. Laboratory investigations were done including complete blood picture, liver enzymes and uric acid.  Results: The mean Hb concentration of the pre-eclamptic (11.3g/dl±1.7) was statistically significantly lower than that of the non-pregnant (12.1g/dl±0.2) (P=0.01) but not from that of the normal pregnant (11.4g/dl±0.1) (P=0.882) .There was no statistical significant difference in the mean WBC count between the pre-eclamptic (7.4x103/mm3±0.3) and non-pregnant (7.3x103/mm3±0.3) (P=0.797) and between the pre-eclamptic and normal pregnant (7.7x103/mm3±0.2) (P=0.270). There was a considerable statistical significant decrease in the mean platelets count of the pre-eclamptic (236.4/mm3±8.3) compared to the non-pregnant group (322.0/mm3±10.4) (P=0.0001) s well as to the normal pregnant (275.0/mm3±8.9) (P = 0.003). In the pre-eclamptic cases, serum ALT correlated significantly with TWCC (r=0.26, P=0.03) and serum AST (r=0.65, P=0.000). In the pre-eclamptic cases, serum AST correlated significantly with Hb (r=0.26, P=0.03), serum ALT and serum uric acid (r=0.36, P=0.01).Conclusions: There was a considerable statistical significant decrease in mean platelets count of the pre-eclamptic compared to the non-pregnant group and to the normal pregnant may be explained by hemodilution; whereas further decrease was due to pre-eclampsia. ALT and AST are strong prognostic indicators of pre-eclampsia.

scholarly journals Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nurshad Ali ◽  
Abu Hasan Sumon ◽  
Khandaker Atkia Fariha ◽  
Md Asaduzzaman ◽  
Rahanuma Raihanu Kathak ◽  
...  
Keyword(s):  
General Population ◽  
Abdominal Obesity ◽  
Liver Enzymes ◽  
Serum Levels ◽  
General Obesity ◽  
Enzymes Activity ◽  
Elevated Liver Enzymes ◽  
Bangladeshi Population ◽  
Relationship Of ◽  
The Relationship

AbstractObesity is a global health concern because of its increasing trend both in developed and developing countries. A limited number of studies have evaluated the association of liver enzymes with both general and abdominal obesity in the general population; data for the Bangladeshi population are not available yet. This study aimed to assess the relationship of serum liver enzymes activity with both general and abdominal obesity in Bangladeshi adults. In total, 540 blood samples were obtained from the participants (388 males and 152 females) and analyzed for serum levels of ALT, AST, GGT, and ALP using standard methods. General obesity was defined as body mass index (BMI) ≥ 27.5 kg/m2 and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm in males and ≥ 80 cm in females. The relationship between liver enzymes and obesity was evaluated by multivariate logistic regression models. Overall, 58% of participants in the general obesity group and 55% of the participants in the abdominal obesity group had at least one or more elevated levels of liver enzymes. The prevalence of elevated liver enzymes was significantly higher in the obesity group compared to the normal BMI and WC groups (p < 0.05 for all cases). The mean level of serum ALT, AST and GGT were significantly higher in the obesity group than the normal BMI group (p < 0.05). In the WC groups, mean AST and GGT were significantly higher in the obesity group compared to the normal group (p < 0.05). In regression analysis, serum levels of ALT showed an independent and significant association with general obesity, whereas, serum GGT showed a significant association with both general and abdominal obesity. In conclusion, a high prevalence of elevated liver enzymes was observed among participants included in the present study. Of the four enzymes, serum GGT was independently associated with both general and abdominal obesity. Further studies are required to understand the complex relationship between liver enzymes and obesity in the general population.

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Platelets ◽  
2013 ◽  
Vol 25 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Masanori Shimodaira ◽  
Tomohiro Niwa ◽  
Koji Nakajima ◽  
Mutsuhiro Kobayashi ◽  
Norinao Hanyu ◽  
...  
Keyword(s):  
Gender Differences ◽  
Uric Acid ◽  
General Population ◽  
Serum Uric Acid ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Japanese General Population ◽  
The Relationship

scholarly journals Correlation between serum uric acid levels and outcomes of pre-eclampsia in Abakaliki, South-east, Nigeria

2021 ◽  
Vol 9 (10) ◽  
pp. 2914
Author(s):  
Nnabugwu A. Adiele ◽  
Odidika U. J. Umeora ◽  
Robinson C. Onoh ◽  
Ikechukwu B. O. Dimejesi ◽  
Arinze C. Ikeotuonye ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Threshold Value ◽  
Controlled Study ◽  
Perinatal Morbidity ◽  
Significant Difference ◽  
The Mean

Background: Pre-eclampsia is a leading cause of fetomaternal and perinatal morbidity and mortality. The role of serum uric acid (SUA) in determining the complications of preeclampsia has been controversial. This study compared mean SUA levels between severe pre-eclamptics and normotensive women at term and ascertained its correlation with outcomes of preeclampsia; as well as determined if there is a threshold value of SUA level beyond which fetomaternal complications occur.Methods: A case-controlled study where 80 severe pre-eclamptics at term and 80 normotensive women matched for gestational age were recruited. Blood samples were collected from them for assay of SUA levels and they were followed till delivery. The fetomaternal outcomes and the corresponding SUA levels at diagnosis were documented and variables statistically analyzed. A receiver operating characteristic curve was used to determine the cut-off value of SUA beyond which adverse fetomateral complications are likely to occur in pre-eclampsia.Results: The mean SUA level in severe pre-eclamptics (0.283±0.09 mmol/l) was not significantly higher than that of normotensive women (0.263±0.09 mmol/l, p=0.13). There was a weak positive correlation between the SUA levels and fetomaternal outcomes [maternal (r=0.102, p=0.236) and fetal (r=0.096, p=0.226)]. The study was unable to identify the threshold SUA level at which adverse fetomaternal outcomes occur as the values of SUA were closely related.Conclusions: SUA levels of pre-eclamptics and normotensive women did not show significant difference and correlated weakly with fetomaternal outcomes and are therefore poor predictor of fetomaternal outcomes in pre-eclampsia.

scholarly journals The Dual Effect of Abnormal Serum Uric Acid on Intervertebral Disc Degeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Ming Yang ◽  
Naiguo Wang ◽  
Wentao Zhang ◽  
Tianze Sun ◽  
Dan Zhang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Intervertebral Disc ◽  
Serum Uric Acid ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Total Population ◽  
Multiple Logistic Regression Analysis ◽  
Significant Difference ◽  
Baseline Characteristics ◽  
The Relationship

An abnormal serum uric acid (SUA) level is associated with many diseases. To our knowledge, there is no research on the association between SUA and intervertebral disc degeneration (IDD). The purpose of this study was to determine the relationship between SUA and IDD. From June 2011 to July 2020, 691 patients undergoing surgery for lumbar disc herniation (LDH) were included in the LDH group, and 684 patients who underwent endoscopic surgery for knee trauma were included in the non-LDH group. We examined the baseline characteristics of all these patients and divided the SUA level into 10 groups according to the percentiles in males, females, and the total population. Subsequently, the relationship between the SUA level and IDD was further analyzed. There was no statistically significant difference in the baseline characteristics of the two groups ( p > 0.05 ). Among the 10 groups, the LDH rate was higher at both lower and higher SUA levels. In multiple logistic regression analysis, after adjustment for age, sex, body mass index, smoking, and drinking, when the SUA level was <20% or >80%, compared with 60–80%, the odds ratio (OR) and 95% confidence interval (CI) of LDH of the total population were 1.821 (1.125–2.946) and 1.701 (1.186–2.438), respectively, and in the males, they were 1.922 (1.169–3.161) and 2.800 (1.766, 4.439), respectively. In females, when the SUA was <20%, there was a higher LDH rate ( OR = 1.951 , 95% CI 1.091-3.486). The present study suggests that there is a U-shaped relationship between SUA and IDD, being particularly prominent among male. Lower and higher SUA level may be risk factors for IDD.

scholarly journals A Study of Relationship Between Serum Uric Acid, and Fasting Plasma Glucose in Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 11 (4) ◽  
pp. 7229-7233
Author(s):  
Anuradha G ◽  
Santhini Gopalakrishnan S ◽  
Vinodakumar H R
Keyword(s):  
Uric Acid ◽  
Linear Regression ◽  
Regression Model ◽  
Serum Uric Acid ◽  
Plasma Glucose ◽  
Linear Regression Model ◽  
Fasting Plasma Glucose ◽  
The Mean ◽  
The Relationship

The current study was conducted to observe the relationship between serum uric acid, lipid profile and fasting plasma glucose in type 2 DM patients. It was a cross-sectional study. A total of 618 participants were included in the study (203-healthy, 206-prediabetic and 209-T2DM). One way analysis of variance was used to compare the mean between these three groups. A linear regression model was used to find the relationship between SUA and FPG in T2DM. The mean values of serum uric acid in pre-diabetes and T2DM (4.929±1.33 and 4.69±1.41 mg/dl, respectively) were lower compared to healthy (5.40±1.08 mg/dl). SUA showed a significant positive correlation with serum triglycerides in T2DM (p<0.05). The linear regression model showed that SUA was inversely associated with FPG in T2DM after adjustment for age and gender. The biological interrelationship observed in the current study raises the possibility of potential pathogenic overlap between SUA and FPG. SUA might be involved in a metabolic imbalance which in turn leads to T2DM.

scholarly journals Relation Of Serum Uric Acid Concentrations With Etiology And Severity In Patients With Cirrhosis Of Liver

2021 ◽  
Vol 5 (2) ◽  
pp. 01-06
Author(s):  
Rashedul Hasan ◽  
Projesh Kumar Roy ◽  
Masudur Rahman Khan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Liver Enzymes ◽  
Serum Uric Acid Level ◽  
Female Ratio ◽  
Positive Correlation ◽  
The Mean ◽  
Cirrhosis Of Liver

Background: Hyperuricemia is now an established factor to cause oxidative stress, insulin resistance and systemic inflammation. So it is likely that hyperuricemia might be involved in hepatic necro-inflammation and destruction which are the common underlying pathophysiology of cirrhosis. On the other hand, as uric acid is the end product of cellular degradation, increased hepatocyte destruction due to any etiology increases the level of serum uric acid which might further aggravate hepatic necro-inflammation, cirrhosis & complications. Objectives: To assess serum uric acid concentrations in patients of cirrhosis of liver and its relation with cirrhosis of different etiology, disease severity and liver enzymes. Materials and Methods: This cross sectional observational study was carried out in the Department of Gastroenterology, BSMMU, Bangladesh during the period of September 2015 to October 2016. A total of 220 diagnosed cases of cirrhosis of liver due to any cause from inpatient & outpatient Department of Gastroenterology of Banghabandhu Sheikh Mujib Medical University were enrolled as the study population. Serum uric acid level was measured in each patient and its relationship with different etiology of cirrhosis, severity of cirrhosis and liver enzymes were assessed. Results: The mean age was found to be 47.8 ± 14.6 years and male: female ratio was 1.9:1. Majority patients (52.3%) belonged to CTP Class C. The mean (±SD) value of serum uric acid was 6.19 (±3.25mg/dl) and hyperuricemia (>7 mg/dl) was detected in 27.73% patients. Among all etiologies of CLD, the higher mean (±SD) level of serum uric acid was found in NAFLD (19.54 ±2.20 mg/dl). There was positive correlation of serum uric acid with liver enzymes. Conclusion: Mean serum uric acid level increased gradually as the cirrhotic patients progressed to higher CTP classes & there was positive correlation of serum uric acid with liver enzymes. It requires further large scale multicenter studies with increased sample size & prolong follow-up to establish serum uric acid as a risk factor of CLD.

A Cross-Sectional Hospital Based Study on Correlation between Serum Uric Acid Levels and Disease Activity in Recently Diagnosed Rheumatoid Arthritis in Chennai, Tamilnadu

2021 ◽  
Vol 8 (38) ◽  
pp. 3372-3377
Author(s):  
Karthiga Murugan ◽  
Velmurugan Anbu Ananthan ◽  
Ananthan Veeranan
Keyword(s):  
Rheumatoid Arthritis ◽  
Uric Acid ◽  
Disease Activity ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Disease Activity Score ◽  
Activity Score ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean

BACKGROUND Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disorder. Uric acid is a by-product of purine metabolism, associated with diseases such as gouty arthritis, hypertension and cardiovascular disease (CVD). The association between serum uric acid concentrations and inflammation in patients with RA has been controversial. Some case reports suggest coexistence of gout and RA. Uric acid crystals can induce robust inflammation causing joint destruction and fibrosis. The purpose of this study was to estimate the serum uric acid levels in subjects with recently diagnosed rheumatoid arthritis and to correlate with disease activity. METHODS This cross-sectional study was done on 55 recently diagnosed RA subjects [American college of Rheumatology (ACR) criteria 2010] attending the rheumatology out-patient department (OPD) of a tertiary care institute in Chennai, Tamil Nadu. After clinical examination, evaluation of disease activity score (DAS), serum uric acid and rheumatoid factor (RF) were done. Data was analysed using Statistical Package for Social Sciences (SPSS trial version 28). Descriptive and inferential analysis was done. Correlation between serum uric acid levels and DAS was the main outcome. RESULTS The mean age was 41.51 ± 11.7 years. 87.3 % were females. Majority (58.2 %) were aged between 31 to 50 years. The mean duration of symptoms was 4.78 months. The mean serum uric acid level was 4.99 ± 1.2 mg/dl with 95 % C.I. of 4.66 to 5.31. The mean DAS was 5.34 ± 0.96. 56 % had high disease activity while only 44 % had moderate disease activity. 44 % were RF positive. There was no significant difference in serum uric acid levels across groups based on RF positivity and DAS severity respectively. There was no statistically significant correlation serum uric acid levels and DAS (-0.024, P value = 0.861). CONCLUSIONS Mean serum uric acid levels were elevated in recently diagnosed rheumatoid arthritis. Serum uric acid levels have no association with DAS and RF positivity in rheumatoid arthritis. Further studies are needed to investigate the role of specific treatment of elevated uric acid levels in rheumatoid arthritis independent of rheumatoid arthritis treatment. KEYWORDS Rheumatoid Arthritis, Uric Acid, Rheumatoid Factor, Disease Activity Score (DAS), Correlation, Recently Diagnosed Rheumatoid Arthritis

scholarly journals Hyperuricemia is associated with progression of CKD: uric acid aggravates renal function

2019 ◽  
Author(s):  
Shulei Fan ◽  
Yang Zou ◽  
Amanda Y Wang ◽  
Mingjie Xu ◽  
Guisen Li ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Metabolic Diseases ◽  
Cox Regression ◽  
Living Standard ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
The Mean

Abstract Background: With the change of living standard and dietary structure, the incidence of hyperuricemia is on the rise. Hyperuricemia has become one of the metabolic diseases threatening human health. There is paucity of literature on the association between serum uric acid levels and the progression of CKD. This study aimed at assessing the effect of serum baseline uric acid level on the progression of CKD. Methods: This retrospective study included 800 CKD patients in our center. The information on baseline and follow-up characteristics were collected from our Renal Treatment System (RTS) database. Cox regression analysis was used to evaluate the risk factors for CKD progression. The Kaplan–Meier analysis was used to test associations between serum uric acid levels and renal survival rates. Results: A total of 800 patients were included in the study, and the mean age at entry was 36.6±14.4 years. There was no significant difference in gender distribution. The mean eGFR, Cr, serum uric acid at baseline were 99.23±31.54 ml/min/1.73㎡, 82.08±41.40 μmol/L, 371.60±103.18 μmol/L, respectively. 306 (38.3%) patients had HUA and 494 (61.7%) had non-HUA. We established different adjusted models and found that HUA was a risk factor for CKD patients to reach the composite endpoint after adjustment in six models. All models show that HUA was a risk factor for the progression of CKD. Among them, model 4 (adjusted for Cr + Alb + age + BP + gender) was the best model with the largest HR value (HR:2.010, 95%CI:1.310-3.084, P<0.05). The cumulative survival rate of non-hyperuricemia group was higher than that of hyperuricemia group (P<0.001). Conclusions: Hyperuricemia was not only widespread in patients with CKD, but also a risk factor for the progression of CKD. Anti-hyperuricemia therapy may need to be considered in CKD patients to slow the disease progression, which needs to be tested further in clinical studies. Key words: hyperuricemia, chronic kidney disease, renal function, progression

scholarly journals Reference Ranges for Serum Uric Acid among Healthy Assamese People

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Madhumita Das ◽  
N. C. Borah ◽  
M. Ghose ◽  
N. Choudhury
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Reference Range ◽  
Healthy Adult ◽  
Serum Uric Acid Level ◽  
Mean Value ◽  
Reference Ranges ◽  
Significant Relation ◽  
Significant Difference ◽  
The Mean

This study was designed to establish reference ranges for serum uric acid among healthy adult Assamese population. Samples from 1470 aged 35–86 years were used to establish age and sex related reference range by the centile method (central 95 percentile) for serum uric acid level. There were 51% (n=754) males and 49% (n=716) females; 75.9% (n=1115) of them were from urban area and the rest 24.1% (n=355) were from the rural area. Majority of the population were nonvegetarian (98.6%,n=1450) and only 1.4% (n=20) were vegetarian. The mean age, weight, height, and uric acid of the studied group were53.6±11.3years,62.6±10.5 kg,160±9.4 cm, and5.5±1.4 mg/dL, respectively. There is a statistically significant difference in the mean value of the abovementioned parameters between male and female. The observed reference range of uric acid in the population is 2.6–8.2 mg/dL which is wider than the current reference range used in the laboratory. Except gender (P<0.0001), we did not find any significant relation of uric acid with other selected factors.

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