scholarly journals Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Rajinder K. Gupta ◽  
G. Himashree ◽  
Krishan Singh ◽  
Poonam Soree ◽  
Koundinya Desiraju ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Brain Natriuretic Peptide ◽  
Pulmonary Edema ◽  
High Altitude ◽  
Natriuretic Peptide ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure ◽  
High Altitude Pulmonary Edema

scholarly journals Higher pulmonary artery pressure in children than in adults upon fast ascent to high altitude

2008 ◽  
Vol 32 (3) ◽  
pp. 664-669 ◽  
Author(s):  
S. Kriemler ◽  
C. Jansen ◽  
A. Linka ◽  
A. Kessel-Schaefer ◽  
M. Zehnder ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure

Effect of oxygen upon pulmonary circulation in acclimatized man at high altitude

1965 ◽  
Vol 20 (2) ◽  
pp. 239-243 ◽  
Author(s):  
H. N. Hultgren ◽  
J. Kelly ◽  
H. Miller
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Sea Level ◽  
Pulmonary Artery Pressure ◽  
Pulmonary Circulation ◽  
Arterial Oxygen ◽  
Artery Pressure ◽  
Oxygen Breathing ◽  
Hypoxic Vasoconstriction ◽  
Arteriolar Resistance

The response to breathing 100% oxygen was studied in 26 acclimatized residents of the Peruvian Andes at altitudes of 12,300 and 14,200 ft. Arterial oxygen saturation increased from 86% to 96%. Mean pulmonary artery pressure decreased by 5 mm Hg and cardiac output did not change. Calculated pulmonary arteriolar resistance was lowered. Pulmonary artery pressure during oxygen breathing was not decreased to normal values observed at sea level. The data suggest the presence of two factors responsible for the increase in pulmonary arteriolar resistance at high altitude: 1) hypoxic vasoconstriction which is reversed by oxygen breathing and 2) anatomic alterations which are not affected by oxygen breathing. Oxygen breathing at high altitude also produced a slowing of the heart rate and increased the relative height of the secondary or tidal wave of the brachial arterial pressure pulse. pulmonary arteriolar resistance and 100% oxygen; arterial pulse contour–effect of 100% oxygen at high altitude; pulmonary arteriolar resistance–nature of in high altitude; hypoxic vasoconstriction at high altitude–reversal by 100% oxygen breathing; oxygen breathing–comparison of effect on pulmonary circulation at high altitude and sea level Submitted on May 8, 1964

scholarly journals Noninvasive Positive Pressure Ventilation against Reperfusion Pulmonary Edema following Percutaneous Transluminal Pulmonary Angioplasty

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kiyoshi Moriyama ◽  
Sayuri Sugiyama ◽  
Koji Uzawa ◽  
Mariko Kotani ◽  
Toru Satoh ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Edema ◽  
Pulmonary Artery Pressure ◽  
Positive Pressure Ventilation ◽  
Noninvasive Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Artery Pressure ◽  
Oxygen Inhalation ◽  
Mean Pulmonary Artery Pressure ◽  
Percutaneous Transluminal

A 69-year-old man with chronic thromboembolic pulmonary hypertension (CTEPH) was on amblatory oxygen inhalation therapy (3 L/min) and scheduled for percutaneous transluminal pulmonary angioplasty (PTPA). The patient's New York Heart Association functional status was class III with recent worsening of dyspnea and apparent leg edema. Transthoracic echocardiography revealed right ventricular enlargement with mean pulmonary artery pressure of 42 mmHg. After PTPA, he was complicated with postoperative reperfusion pulmonary edema, and noninvasive positive pressure ventilation (NPPV) was applied immediately. Hypoxemia was successfully treated with 15 days of NPPV. Although mean pulmonary artery pressure was unchanged, his brain natriuretic peptide level decreased from preoperative 390.3 to postoperative 44.3 pg/dL. In addition, total pulmonary resistance decreased from preoperative 18 to postoperative 9.6 wood unit·m2. The patient was discharged on day 25 with SpO2of 95% on 5 L/min of oxygen inhalation. Because pulmonary edema is a postsurgical life-threatening complication following PTPA, application of NPPV should be considered.

scholarly journals Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents

2012 ◽  
Vol 13 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Baktybek Kojonazarov ◽  
Jainagul Isakova ◽  
Bakytbek Imanov ◽  
Nurmira Sovkhozova ◽  
Talantbek Sooronbaev ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Altitude ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure

scholarly journals Brain Natriuretic Peptide and NT-proBNP Levels Reflect Pulmonary Artery Systolic Pressure in Trekkers at High Altitude

2013 ◽  
pp. 597-603 ◽  
Author(s):  
D. R. WOODS ◽  
A. MELLOR ◽  
J. BEGLEY ◽  
M. STACEY ◽  
J. O’HARA ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Brain Natriuretic Peptide ◽  
High Altitude ◽  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Central Feature ◽  
Post Exercise ◽  
Echocardiographic Assessment

Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to 5150 m. PASP increased significantly (p=0.006) with ascent from 24±4 to 39±11 mm Hg at 5150 m. At 5150 m those with a PASP≥40 mm Hg (n=8) (versus those with PASP<40 mm Hg) had higher post-exercise BNP (pg/ml): 54.5±36 vs. 13.4±17 (p=0.012). Their resting BNP at 5150 m was also higher: 57.3±43.4 vs. 12.6±13 (p=0.017). In those with a pathological (≥400 pg/ml) rise in NT-proBNP at 5150 m (n=4) PASP was significantly higher: 45.9±7.5 vs. 32.2±6.2 mm Hg (p=0.015). BNP and NT-proBNP may reflect elevated PASP, a central feature of high altitude pulmonary oedema, at HA.

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