scholarly journals Rumination and Default Mode Network Subsystems Connectivity in First-episode, Drug-Naive Young Patients with Major Depressive Disorder

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xueling Zhu ◽  
Qiuling Zhu ◽  
Huaizhen Shen ◽  
Weihua Liao ◽  
Fulai Yuan
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
Young Patients ◽  
First Episode ◽  
Major Depressive ◽  
Default Mode ◽  
Drug Naïve

scholarly journals Abnormal Default-Mode Network Homogeneity in First-Episode, Drug-Naive Major Depressive Disorder

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91102 ◽  
Author(s):  
Wenbin Guo ◽  
Feng Liu ◽  
Jian Zhang ◽  
Zhikun Zhang ◽  
Liuyu Yu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
First Episode ◽  
Major Depressive ◽  
Default Mode ◽  
Drug Naïve

scholarly journals Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest

Medicine ◽  
2015 ◽  
Vol 94 (9) ◽  
pp. e560 ◽  
Author(s):  
Wenbin Guo ◽  
Feng Liu ◽  
Jianrong Liu ◽  
Miaoyu Yu ◽  
Zhikun Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
Network Connectivity ◽  
Major Depressive ◽  
Default Mode ◽  
Drug Naïve

scholarly journals Reduced default mode network functional connectivity in patients with recurrent major depressive disorder

2019 ◽  
Vol 116 (18) ◽  
pp. 9078-9083 ◽  
Author(s):  
Chao-Gan Yan ◽  
Xiao Chen ◽  
Le Li ◽  
Francisco Xavier Castellanos ◽  
Tong-Jian Bai ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
Statistical Power ◽  
Resting State Fmri ◽  
Response To Treatment ◽  
First Episode ◽  
Major Depressive ◽  
Default Mode

Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.

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