Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

Folate-targeting and bovine serum albumin-gated mesoporous silica nanoparticles as a redox-responsive carrier for epirubicin release

2019 ◽  
Vol 43 (6) ◽  
pp. 2694-2701 ◽  
Author(s):  
Yuan Zhang ◽  
Yang Xing ◽  
Ming Xian ◽  
Shaomin Shuang ◽  
Chuan Dong
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Serum Albumin ◽  
Cancer Cells ◽  
Bovine Serum ◽  
Mesoporous Silica Nanoparticles ◽  
Redox Responsive ◽  
Folate Targeting ◽  
Triggered Drug Release

A targeted DDS with covalently conjugated BSA and folate for GSH-triggered drug release and recognition of FR-positive cancer cells.

scholarly journals Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization

2019 ◽  
Vol 7 (2) ◽  
pp. 607-617 ◽  
Author(s):  
Sussana A. Elkassih ◽  
Petra Kos ◽  
Hu Xiong ◽  
Daniel J. Siegwart
Keyword(s):  
Drug Release ◽  
Small Molecules ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Stimuli Responsive ◽  
Redox Responsive

Stimuli-responsive nanogels degrade to small molecules in reducing environments to mediate controlled drug release.

ZnO embedded PEG-PLGA nanoparticles as drug carriers for NIR-triggered drug release

2017 ◽  
Vol 259 ◽  
pp. e194-e195
Author(s):  
Zhuangzhi Zhi ◽  
Yuxiao Li ◽  
Liang Zhao ◽  
Daquan Chen ◽  
Huazhe Yang
Keyword(s):  
Drug Release ◽  
Drug Carriers ◽  
Plga Nanoparticles ◽  
Triggered Drug Release

Magnetic/NIR-thermally responsive hybrid nanogels for optical temperature sensing, tumor cell imaging and triggered drug release

Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 13001-13011 ◽  
Author(s):  
Hui Wang ◽  
Jinhui Yi ◽  
Sumit Mukherjee ◽  
Probal Banerjee ◽  
Shuiqin Zhou
Keyword(s):  
Magnetic Properties ◽  
Drug Release ◽  
Tumor Cell ◽  
Cell Imaging ◽  
Drug Carriers ◽  
Temperature Sensing ◽  
Core Shell ◽  
Thermally Responsive ◽  
Triggered Drug Release

The paper demonstrates a class of multifunctional core–shell hybrid nanogels with fluorescent and magnetic properties, which have been successfully developed for simultaneous optical temperature sensing, tumor cell imaging and magnetic/NIR-thermally responsive drug carriers.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

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