scholarly journals Detection of molecular binding via charge-induced mechanical response of optical fibers

2014 ◽  
Vol 5 (11) ◽  
pp. 4375-4381 ◽  
Author(s):  
Yan Guan ◽  
Xiaonan Shan ◽  
Shaopeng Wang ◽  
Peiming Zhang ◽  
Nongjian Tao
Keyword(s):  
Optical Fibers ◽  
Molecular Interactions ◽  
Mechanical Response ◽  
Optical Detection ◽  
Detection Technique ◽  
Label Free ◽  
Molecular Binding ◽  
A Charge

We report a charge sensitive optical detection technique for the label-free study of molecular interactions.

scholarly journals Critical angle reflection imaging for quantification of molecular interactions on glass surface

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guangzhong Ma ◽  
Runli Liang ◽  
Zijian Wan ◽  
Shaopeng Wang
Keyword(s):  
Refractive Index ◽  
Small Molecule ◽  
Molecular Interactions ◽  
Glass Surface ◽  
Critical Angle ◽  
Dynamic Range ◽  
Refractive Index Change ◽  
Label Free ◽  
Index Change ◽  
Sensing Range

AbstractQuantification of molecular interactions on a surface is typically achieved via label-free techniques such as surface plasmon resonance (SPR). The sensitivity of SPR originates from the characteristic that the SPR angle is sensitive to the surface refractive index change. Analogously, in another interfacial optical phenomenon, total internal reflection, the critical angle is also refractive index dependent. Therefore, surface refractive index change can also be quantified by measuring the reflectivity near the critical angle. Based on this concept, we develop a method called critical angle reflection (CAR) imaging to quantify molecular interactions on glass surface. CAR imaging can be performed on SPR imaging setups. Through a side-by-side comparison, we show that CAR is capable of most molecular interaction measurements that SPR performs, including proteins, nucleic acids and cell-based detections. In addition, we show that CAR can detect small molecule bindings and intracellular signals beyond SPR sensing range. CAR exhibits several distinct characteristics, including tunable sensitivity and dynamic range, deeper vertical sensing range, fluorescence compatibility, broader wavelength and polarization of light selection, and glass surface chemistry. We anticipate CAR can expand SPR′s capability in small molecule detection, whole cell-based detection, simultaneous fluorescence imaging, and broader conjugation chemistry.

Label-free and noninvasive optical detection of the distribution of nanometer-size mitochondria in single cells

2011 ◽  
Vol 16 (6) ◽  
pp. 067003 ◽  
Author(s):  
Xuantao Su ◽  
Yuanyuan Qiu ◽  
Leah Marquez-Curtis ◽  
Manisha Gupta ◽  
Clarence E. Capjack ◽  
...  
Keyword(s):  
Single Cells ◽  
Optical Detection ◽  
Label Free ◽  
Nanometer Size

Label-free optical detection of cells grown in 3D silicon microstructures

Lab on a Chip ◽  
2013 ◽  
Vol 13 (16) ◽  
pp. 3284 ◽  
Author(s):  
Sabina Merlo ◽  
Francesca Carpignano ◽  
Gloria Silva ◽  
Francesca Aredia ◽  
A. Ivana Scovassi ◽  
...  
Keyword(s):  
Optical Detection ◽  
Label Free ◽  
Silicon Microstructures

Quantum dot-assembled nanoparticles with polydiacetylene supramolecule toward label-free, multiplexed optical detection

2013 ◽  
Vol 394 ◽  
pp. 44-48 ◽  
Author(s):  
San Kyeong ◽  
Homan Kang ◽  
Joonhyuk Yim ◽  
Su-Ji Jeon ◽  
Cheol Hwan Jeong ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Optical Detection ◽  
Label Free

In-vivo label-free optical detection of neural activities in retina (Conference Presentation)

2018 ◽  
Author(s):  
Subrata Batabyal ◽  
Sivakumar Gajjeraman ◽  
Weldon Wright ◽  
Samarendra K. Mohanty
Keyword(s):  
Optical Detection ◽  
Label Free ◽  
Neural Activities

Free-Solution, Label-Free Molecular Interactions Studied by Back-Scattering Interferometry

Science ◽  
2007 ◽  
Vol 317 (5845) ◽  
pp. 1732-1736 ◽  
Author(s):  
D. J. Bornhop ◽  
J. C. Latham ◽  
A. Kussrow ◽  
D. A. Markov ◽  
R. D. Jones ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
Free Solution ◽  
Label Free ◽  
Back Scattering
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