scholarly journals High-density lipoproteins for therapeutic delivery systems

2016 ◽  
Vol 4 (2) ◽  
pp. 188-197 ◽  
Author(s):  
R. Kannan Mutharasan ◽  
Linda Foit ◽  
C. Shad Thaxton

High-density lipoproteins are a class of natural nanostructures with multiple desirable properties to model in a drug delivery vehicle. Here we review the structure and function of high-density lipoproteins, and their use as therapeutic delivery systems.

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Harry S. Courtney ◽  
Henry J. Pownall

Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunctional protein and in addition to its opacification activity, it binds to a number of host proteins that mediate adhesion of streptococci to host cells, and it plays a role in resistance to phagocytosis in human blood. This article will provide an overview of the structure and function of SOF, its role in the pathogenesis of streptococcal infections, its vaccine potential, its prevalence and distribution in bacteria, and the molecular mechanism whereby SOF opacifies serum and how an understanding of this mechanism may lead to therapies for reducing high-cholesterol concentrations in blood, a major risk factor for cardiovascular disease.


2017 ◽  
Vol 526 (1-2) ◽  
pp. 309-320 ◽  
Author(s):  
Márcia Alves ◽  
Nicole S.M. Vieira ◽  
Luís Paulo N. Rebelo ◽  
João M.M. Araújo ◽  
Ana B. Pereiro ◽  
...  

2001 ◽  
Vol 42 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Sylvie Braschi ◽  
Cynthia R. Coffill ◽  
Tracey A-M. Neville ◽  
Darren M. Hutt ◽  
Daniel L. Sparks

2019 ◽  
Vol 42 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Hiroyuki Taguchi ◽  
Haruki Tanaka ◽  
Kaname Hashizaki ◽  
Yoshihiro Saito ◽  
Makiko Fujii

ACS Omega ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 3143-3155 ◽  
Author(s):  
Gopal Pandit ◽  
Karabi Roy ◽  
Umang Agarwal ◽  
Sunanda Chatterjee

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