Efficient two-photon luminescence for cellular imaging using biocompatible nitrogen-doped graphene quantum dots conjugated with polymers

Nanoscale ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Ping-Ching Wu ◽  
Jiu-Yao Wang ◽  
Wen-Lung Wang ◽  
Chia-Yuan Chang ◽  
Chia-Hung Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Contrast Agent ◽  
Graphene Quantum Dots ◽  
Cellular Imaging ◽  
Deep Tissue ◽  
Nitrogen Doped ◽  
Two Photon ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

N-doped GQDs conjugated with polymers demonstrate impressive two-photon properties and stability, and can be used as a contrast agent in deep tissue bioimaging.

Nitrogen-doped graphene quantum dots-based fluorescent probe for the sensitive turn-on detection of glutathione and its cellular imaging

RSC Advances ◽  
2014 ◽  
Vol 4 (94) ◽  
pp. 52583-52589 ◽  
Author(s):  
Jian Ju ◽  
Ruizhong Zhang ◽  
Shuijian He ◽  
Wei Chen
Keyword(s):  
Quantum Dots ◽  
Fluorescent Probe ◽  
Graphene Quantum Dots ◽  
Living Cells ◽  
Cellular Imaging ◽  
Nitrogen Doped ◽  
Turn On ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene ◽  
Fluorescence Turn On

Fluorescence turn-on sensor based on nitrogen-doped graphene quantum dots can be used for glutathione detection in living cells.

Nitrogen-doped graphene quantum dots coupled with photosensitizers for one-/two-photon activated photodynamic therapy based on a FRET mechanism

2018 ◽  
Vol 54 (7) ◽  
pp. 715-718 ◽  
Author(s):  
Jiaheng Sun ◽  
Qi Xin ◽  
Yang Yang ◽  
Hameed Shah ◽  
Hongqian Cao ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Graphene Quantum Dots ◽  
Nitrogen Doped ◽  
Two Photon ◽  
Photon Excitation ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene ◽  
Two Photon Excitation

Photosensitizers can be excited by nitrogen-doped graphene quantum dots under one-/two-photon excitation through an intramolecular FRET mechanism and induced phototoxicity.

Sulfur and nitrogen-doped graphene quantum dots/PANI nanocomposites for supercapacitors

2021 ◽  
Author(s):  
Hemalatha Kuzhandaivel ◽  
Sornalatha Manickam ◽  
Suresh Kannan Balasingam ◽  
Manik Clinton Franklin ◽  
Hee-Je Kim ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Charge Storage ◽  
Nitrogen Doped ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene ◽  
Supercapacitor Applications ◽  
Storage Properties

Sulfur and nitrogen-doped graphene quantum dots/polyaniline nanocomposites were synthesized and their electrochemical charge storage properties were tested for supercapacitor applications.

scholarly journals Nanocomposite of CuInS/ZnS and Nitrogen-Doped Graphene Quantum Dots for Cholesterol Sensing

ACS Omega ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 2167-2176
Author(s):  
Rania Adel ◽  
Shaker Ebrahim ◽  
Azza Shokry ◽  
Moataz Soliman ◽  
Marwa Khalil
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Nitrogen Doped ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

scholarly journals Effects of Doxorubicin Delivery by Nitrogen-Doped Graphene Quantum Dots on Cancer Cell Growth: Experimental Study and Mathematical Modeling

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Madison Frieler ◽  
Christine Pho ◽  
Bong Han Lee ◽  
Hana Dobrovolny ◽  
Giridhar R. Akkaraju ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cell Growth ◽  
Cancer Cell ◽  
Graphene Quantum Dots ◽  
Maximum Effect ◽  
Cancer Cell Growth ◽  
Nitrogen Doped ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the Emax value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained IC50 (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs). These biocompatible/biodegradable nanoparticles were used for the first time in this work for the delivery and fluorescence tracking of doxorubicin, ultimately decreasing its IC50 by over 1.5 and allowing for the use of up to 10 times lower doses of the drug to achieve the same therapeutic effect. Based on the experimental in vitro studies with nanomaterial-delivered chemotherapy, we also developed a method of cancer cell growth modeling that (1) includes an Emax value, which is often not characterized, and (2), most importantly, is measurement time-independent. This will allow for the more consistent assessment of the efficiency of anti-cancer drugs and nanomaterial-delivered formulations, as well as efficacy improvements of nanomaterial delivery.

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