Bacterial cellulose–TiO2 nanocomposites promote healing and tissue regeneration in burn mice model

The development of novel cutaneous wound treatments particularly for burns is of paramount importance due to complex pathophysiology, prevalent infection and clinical complexities associated with burn care.

Download Full-text

Use of heparinized bacterial cellulose based scaffold for improving angiogenesis in tissue regeneration

Carbohydrate Polymers ◽

10.1016/j.carbpol.2017.11.055 ◽

2018 ◽

Vol 181 ◽

pp. 948-956 ◽

Cited By ~ 17

Author(s):

Baoxiu Wang ◽

Xiangguo Lv ◽

Shiyan Chen ◽

Zhe Li ◽

Jingjing Yao ◽

...

Keyword(s):

Bacterial Cellulose ◽

Tissue Regeneration

Download Full-text

Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v14i2.40098 ◽

2019 ◽

Vol 14 (2) ◽

pp. 101-106

Author(s):

Zainab Qureshi ◽

Taous Khan ◽

Abdul Jabbar Shah ◽

Fazli Wahid

Keyword(s):

Wound Healing ◽

Tissue Regeneration ◽

Histological Analysis ◽

Negative Control ◽

Wound Contraction ◽

Mice Model ◽

Wound Area ◽

Solanum Incanum ◽

Partial Thickness ◽

Partial Thickness Burn

This study was conducted to evaluate the topical efficacy of Solanum incanum for the treatment of partial-thickness burn in mice model. Mice were treated with topical ointment of S. incanum three times daily for 14 days. The wound healing was observed through wound contraction and histological parameters. The group treated with S. incanum ointment showed 81% reduction in wound area as compared to negative control where wound area reduced to 22%. The histological analysis further confirmed that ointment favors the tissue regeneration and reepithelization thus heal wound rapidly as com-pared to other groups. In conclusion, S. incanum extract enhances wound healing and tissue regeneration.

Download Full-text

Bacterial cellulose membrane conjugated with plant-derived osteopontin: Preparation and its potential for bone tissue regeneration

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.01.158 ◽

2020 ◽

Vol 149 ◽

pp. 51-59 ◽

Cited By ~ 5

Author(s):

Nichapa Klinthoopthamrong ◽

Daneeya Chaikiawkeaw ◽

Waranyoo Phoolcharoen ◽

Kaewta Rattanapisit ◽

Pornjira Kaewpungsup ◽

...

Keyword(s):

Bacterial Cellulose ◽

Bone Tissue ◽

Tissue Regeneration ◽

Bone Tissue Regeneration ◽

Cellulose Membrane ◽

Bacterial Cellulose Membrane

Download Full-text

Bacterial cellulose/gelatin scaffold loaded with VEGF-silk fibroin nanoparticles for improving angiogenesis in tissue regeneration

Cellulose ◽

10.1007/s10570-017-1472-x ◽

2017 ◽

Vol 24 (11) ◽

pp. 5013-5024 ◽

Cited By ~ 12

Author(s):

Baoxiu Wang ◽

Xiangguo Lv ◽

Shiyan Chen ◽

Zhe Li ◽

Jingjing Yao ◽

...

Keyword(s):

Bacterial Cellulose ◽

Silk Fibroin ◽

Tissue Regeneration ◽

Silk Fibroin Nanoparticles

Download Full-text

Harnessing the Natural Healing Power of Colostrum: Bovine Milk‐derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing

Advanced Healthcare Materials ◽

10.1002/adhm.202102027 ◽

2021 ◽

pp. 2102027

Author(s):

Hyosuk Kim ◽

Da Eun Kim ◽

Geonhee Han ◽

Nu Ri Lim ◽

Eun Hye Kim ◽

...

Keyword(s):

Wound Healing ◽

Extracellular Vesicles ◽

Tissue Regeneration ◽

Bovine Milk ◽

Cutaneous Wound Healing ◽

Cutaneous Wound ◽

Healing Power ◽

Natural Healing

Download Full-text

Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model

Acta Scientiarum Biological Sciences ◽

10.4025/actascibiolsci.v42i1.47680 ◽

2020 ◽

Vol 42 ◽

pp. e47680

Author(s):

Ana Maria Sampaio Assreuy ◽

Beatriz Lima Adjafre ◽

Évilla Rayanne Oliveira Sousa ◽

Ana Paula Negreiros Nunes Alves ◽

Alana de Freitas Pires ◽

...

Keyword(s):

Antinociceptive Effect ◽

Folk Medicine ◽

New Drugs ◽

Northeastern Brazil ◽

Mountain Range ◽

Myeloperoxidase Activity ◽

Mice Model ◽

Bioactive Substances ◽

Thermal Nociception ◽

Cutaneous Wound

Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ‘‘Serra de Maranguape’’ (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone, and the venom secreted by the ant glands was extracted with capillary tubes, further lyophilized and maintained at -20 ± 1ºC until use. Wounds were performed in the dorsum of Swiss mice. Animals received intravenous (i.v.) injection of DqV (50 µg -1kg day-1) during 3 days for evaluation of inflammatory parameters present in the wounds: hypernociception, leukocyte infiltrate, myeloperoxidase activity, nitrite nitrate-1 content. Data was tested by two-way ANOVA and Bonferroni’s post-hoc test. DqV reduced (2.7 folds) hypernociception at 48 hours, leukocyte infiltration by 65% at 6 hours and myeloperoxidase activity by 60% at 0.5 hour after wound induction. In conclusion, the venom extracted from D. quadriceps glands attenuates inflammation and hypernociception in mice cutaneous wounds.

Download Full-text

Repeated Intravenous Administration of hiPSC-MSCs Enhance The Efficacy of Cell-Based Therapy In Tissue Regeneration

10.21203/rs.3.rs-916735/v1 ◽

2021 ◽

Author(s):

Si-Jia Sun ◽

Ming Dong ◽

Wing-Hon Lai ◽

Wai-In Ho ◽

Rui Wei ◽

...

Keyword(s):

Tissue Regeneration ◽

Intravenous Administration ◽

Therapeutic Efficacy ◽

Hind Limb ◽

Blood Perfusion ◽

Limb Ischemia ◽

Mice Model ◽

Hind Limb Ischemia ◽

Cell Based Therapy ◽

Left Femoral Artery

Abstract We sought to demonstrate whether therapeutic efficacy can be improved by combination of repeated intravenous administration and local transplantation of human induced pluripotential stem cell derived MSCs (hiPSC-MSCs). In this study, mice model of hind-limb ischemia was established by ligation of left femoral artery. hiPSC-MSCs (5x105) was intravenously administrated immediately after induction of hind limb ischemia with or without following intravenous administration of hiPSC-MSCs every week or every 3 days. Intramuscular transplantation of hiPSC-MSCs (3x106) was performed one week after induction of hind-limb ischemia. We compared the therapeutic efficacy and cell survival of intramuscular transplantation of hiPSC-MSCs with or without a single or repeated intravenous administration of hiPSC-MSCs. Repeated intravenous administration of hiPSC-MSCs could increase splenic regulatory T cells (Tregs) activation, decrease splenic natural killer (NK) cells expression, promote the polarization of M2 macrophages in the ischemic area and improved blood perfusion in the ischemic limbs. The improved therapeutic efficacy of MSC-based therapy was due to both increased engraftment of intramuscular transplanted hiPSC-MSCs and intravenous infused hiPSC-MSCs. In conclusion, our study supported a combination of repeated systemic infusion and local transplantation of hiPSC-MSCs for cardiovascular disease.

Download Full-text