Eosin-mediated synthesis of polymer coatings combining photodynamic inactivation and antimicrobial properties

ABSTRACT Aim The present study was conducted to evaluate the efficacy of commercially available herbal toothpastes against the different periodontopathogens. Materials and methods Six herbal toothpastes that were commonly commercially available were included in the study. Colgate herbal, Babool, Meswak, Neem active, Dabur red toothpastes were tested for the study whereas sterile normal saline was used as control. Antimicrobial efficacies of dentifrices were evaluated against Streptococcus mutans and Actinobacillus actinomycetemcomitans. The antimicrobial properties of dentifrices were tested by measuring the maximum zone of inhibition at 24 hours on the Mueller Hinton Agar media inoculated with microbial strain using disk diffusion method. Each dentifrice was tested at 100% concentration (full strength). Results The study showed that all dentifrices selected for the study were effective against the entire test organism but to varying degree. Neem active tooth paste gave a reading of 25.4 mm as the zone of inhibition which was highest amongst all of the test dentifrices. Colgate Herbal and Meswak dentifrices recorded a larger maximum zone of inhibition, measuring 23 and 22.6 mm respectively, compared to other toothpastes. All other dentifrices showed the zone of inhibition to be between 17 and 19 mm respectively. Conclusion The antibacterial properties of six dentifrices were studied in vitro and concluded that almost all of the dentifrices available commercially had antibacterial properties to some extent to benefit dental health or antiplaque action. How to cite this article Jenner F, Jaleel VA, Kulshrestha R, Maheswar G, Rao PK, Kranthi J. Evaluating the Antimicrobial Activity of Commercially Available Herbal Toothpastes on Microorganisms Associated with Diabetes Mellitus. J Contemp Dent Pract 2013;14(5):924-929.

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Production and Characterization of Keratin/Tragacanth Gum Nanohydrogels for Drug Delivery in Medical Textiles

Frontiers in Materials ◽

10.3389/fmats.2021.720385 ◽

2021 ◽

Vol 8 ◽

Author(s):

Nazanin Mansouri Shirazi ◽

Niloofar Eslahi ◽

Adeleh Gholipour-Kanani

Keyword(s):

Disulfide Bonds ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

Spherical Shape ◽

Herbal Extract ◽

Minimum Size ◽

Mechanical Resistance ◽

Tragacanth Gum ◽

Medical Textiles

Keratin protein has been applied for biomedical applications due to its biocompatibility, biodegradability, mechanical resistance, and bioavailability. Tragacanth gum (TG) as a polysaccharide-based biopolymer has wound healing and antimicrobial properties. In this study, keratin was extracted from protein-based chicken feather by using reduction hydrolysis (sodium sulfide), and nanogels of keratin and TG composites at different ratios were produced by using the chemical cross-linking method. Then, cinnamon (5 and 10%) as an antibacterial herbal extract was added to the nanogels and coated on cotton fabric. The morphology and size of the composite nanogels, chemical structure, biological, and antibacterial properties were evaluated. According to DLS results, TGK2:1 (ratio of TG to keratin = 2:1) had the minimum size (80 nm) and PDI (0.1), and therefore, this sample was chosen as the optimum one. FESEM and TEM images showed the semi-spherical shape of the produced nanogels. FTIR spectra revealed the possible hydrogen bonding between the components, and the formation of disulfide bonds after the addition of hydrogen peroxide was confirmed by XPS. After loading cinnamon into the nanogels, an increase in size was observed from 80 nm for free-nanogel to 85 and 105 nm for 5 and 10% extract-loaded nanogels, respectively. Besides, more cinnamon was released from the treated fabrics by increasing time and cinnamon concentration. The antibacterial test exhibited good antibacterial properties against both Gram-positive and Gram-negative bacteria. Finally, MTT assay approved the biocompatibility of the produced nanogels for potential use in medical textiles.

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Barrier and Antibacterial Properties of 2-Octyl Cyanoacrylate-Derived Wound Treatment Films

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347540300700101 ◽

2003 ◽

Vol 7 (1) ◽

pp. 1-6 ◽

Cited By ~ 29

Author(s):

Patricia M. Mertz ◽

Stephen C. Davis ◽

Alejandro L. Cazzaniga ◽

Anna Drosou ◽

William H. Eaglstein

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Bacterial Contamination ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

Bacterial Invasion ◽

Wound Treatment ◽

Antimicrobial Study ◽

And Control ◽

Number Of Bacteria

Background: Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds. Objective: To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swines. Methods: Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment. Results: Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups. Conclusion: LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.

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Exposure-Dependent Antimicrobial Activity and Oxidative Properties of Polymer-Based Graphene Oxide Nanocomposites

Materials Science Forum ◽

10.4028/www.scientific.net/msf.947.13 ◽

2019 ◽

Vol 947 ◽

pp. 13-20

Author(s):

Jem Valerie D. Perez ◽

Joy Vanessa D. Perez ◽

Raniv D. Rojo ◽

Maria Lourdes P. Dalida ◽

Debora F. Rodrigues

Keyword(s):

Antimicrobial Activity ◽

Graphene Oxide ◽

Membrane Damage ◽

Antimicrobial Properties ◽

Dynamic Contact ◽

Bacterial Inactivation ◽

E Coli ◽

Enhanced Production ◽

Prolonged Contact ◽

Species Production

Bacterial proliferation and biofilm formation has emerged as a significant concern in the long-term use of industrial apparatus. This study describes the antimicrobial properties of a novel chitosan-polyethyleneimine-graphene oxide (CS-PEI-GO) nanocomposite against E. coli. The nanocomposite is a stable material with minimal dispersibility in storage water after more than 7 days. The antimicrobial activity is contact-time-dependent, with direct contact (92% bacterial inactivation after 3h exposure) having superior results compared with dynamic contact (~50% inactivation after 3h exposure). In addition, the incorporation of GO also translated to enhanced production of ROS—oxidation of GSH was higher in CS-PEI-GO (31.78%) as compared to CS-PEI alone (5.69%). This may be attributed to previously proposed mechanisms of mechanical membrane damage and reactive oxygen species production that may be more pronounced with prolonged contact. This may be due to the positively charged chitosan and the negatively charged cell membrane facilitating the coating of cells that could allow the oxygen-containing functional groups of GO to induce oxidative stress and lead to cell death.

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Synthesis and Antimicrobial Properties of Zinc Oxide Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.18707 ◽

2020 ◽

Vol 20 (10) ◽

pp. 5977-5996 ◽

Cited By ~ 1

Author(s):

Saee Gharpure ◽

Balaprasad Ankamwar

Keyword(s):

Zinc Oxide ◽

Zno Nanoparticles ◽

Zinc Oxide Nanoparticles ◽

Metal Oxide Nanoparticles ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

Physical Contact ◽

Oxide Nanoparticles ◽

Synthesis Methods ◽

Promising Alternative

With increase in incidence of multidrug resistant pathogens, there is a demand to adapt newer approaches in order to combat these diseases as traditional therapy is insufficient for their treatment. Use of nanotechnology provides a promising alternative as antimicrobial agents as against traditional antibiotics. Metal oxides have been exploited for a long times for their antimicrobial properties. Zinc oxide nanoparticles (ZnO NPs) are preferred over other metal oxide nanoparticles because of their bio-compatible nature and excellent antibacterial potentials. The basic mechanism of bactericidal nature of ZnO nanoparticles includes physical contact between ZnO nanoparticles and the bacterial cell wall, generation of reactive oxygen species (ROS) as well as free radicals and release of Zn2+ ions. This review focuses on different synthesis methods of ZnO nanoparticles, various analytical techniques frequently used for testing antibacterial properties, mechanism explaining antibacterial nature of ZnO nanoparticles as well as different factors affecting the antibacterial properties.

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Inactivation of Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella in Cranberry, Lemon, and Lime Juice Concentrates

Journal of Food Protection ◽

10.4315/0362-028x-66.9.1637 ◽

2003 ◽

Vol 66 (9) ◽

pp. 1637-1641 ◽

Cited By ~ 36

Author(s):

MARA C. L. NOGUEIRA ◽

OMAR A. OYARZÁBAL ◽

DAVID E. GOMBAS

Keyword(s):

Escherichia Coli ◽

Listeria Monocytogenes ◽

Pathogenic Bacteria ◽

Antimicrobial Properties ◽

Escherichia Coli O157 ◽

Bacterial Inactivation ◽

Lime Juice ◽

E Coli ◽

Log Reduction ◽

C 32

The production of thermally concentrated fruit juices uses temperatures high enough to achieve at least a 5-log reduction of pathogenic bacteria that can occur in raw juice. However, the transportation and storage of concentrates at low temperatures prior to final packaging is a common practice in the juice industry and introduces a potential risk for postconcentration contamination with pathogenic bacteria. The present study was undertaken to evaluate the likelihood of Escherichia coli O157: H7, Listeria monocytogenes and Salmonella surviving in cranberry, lemon, and lime juice concentrates at or above temperatures commonly used for transportation or storage of these concentrates. This study demonstrates that cranberry, lemon, and lime juice concentrates possess intrinsic antimicrobial properties that will eliminate these bacterial pathogens in the event of postconcentration recontamination. Bacterial inactivation was demonstrated under all conditions; at least 5-log Salmonella inactivation was consistently demonstrated at −23°C (−10°F), at least 5-log E. coli O157:H7 inactivation was consistently demonstrated at −11°C (12°F), and at least 5-log L. monocytogenes inactivation was consistently demonstrated at 0°C (32°F).

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Antibacterial properties of electrospun Ti3C2Tz(MXene)/chitosan nanofibers

RSC Advances ◽

10.1039/c8ra06274a ◽

2018 ◽

Vol 8 (62) ◽

pp. 35386-35394 ◽

Cited By ~ 20

Author(s):

Elisa A. Mayerberger ◽

Reva M. Street ◽

Riki M. McDaniel ◽

Michel W. Barsoum ◽

Caroline L. Schauer

Keyword(s):

Low Cost ◽

Antibacterial Properties ◽

Antimicrobial Properties

Electrospun natural polymeric bandages are highly desirable due to their low-cost, biodegradability, non-toxicity and antimicrobial properties.

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Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity

Molecules ◽

10.3390/molecules25040951 ◽

2020 ◽

Vol 25 (4) ◽

pp. 951 ◽

Cited By ~ 3

Author(s):

Michał Abendrot ◽

Lilianna Chęcińska ◽

Joachim Kusz ◽

Katarzyna Lisowska ◽

Katarzyna Zawadzka ◽

...

Keyword(s):

Amino Acids ◽

Antibacterial Activity ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

X Ray Diffraction ◽

Organic Zinc ◽

Counter Ions ◽

Open Issue ◽

Potential Use ◽

Active Substances

The multifunctional profile of Zn2+ has influenced its great popularity in various pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic zinc derivatives, the search for new zinc-containing compounds with a safer skin profile still remains an open issue. The present paper describes the synthesis, structural characterization, and antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2], where AA represents an amino acid (L-Glu, Gly, L-His, L-Pro, L-Met, and L-Trp). Their synthesis was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any counter-ions such as Cl−, NO3−, or SO42− that can cause some skin irritations. The chemical structure and composition of the compounds were identified by 1H NMR spectroscopy and elemental analysis, and four were also characterized by single-crystal X-ray diffraction. The Hirshfeld surface analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for each complex. Finally, the antibacterial properties of the complexes were determined with respect to three Gram-positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram-negative bacteria, viz. Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the activity of zinc 2-pirrolidone 5-carboxylate (ZnPCA), commonly applied in dermatology. It was found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial activity than the tested standard, and the antimicrobial properties of complex with Trp were satisfactory. The results of the antimicrobial activity examination allow us to postulate that the obtained zinc complexes might become new active substances for use in dermatological products.

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Antibacterial Properties of Silver-Loaded Plasma Polymer Coatings

Journal of Nanomaterials ◽

10.1155/2012/674145 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 22

Author(s):

Lydie Ploux ◽

Mihaela Mateescu ◽

Karine Anselme ◽

Krasimir Vasilev

Keyword(s):

Polymer Matrix ◽

Plasma Polymerization ◽

Antibacterial Effect ◽

Antibacterial Properties ◽

Polymer Coatings ◽

Plasma Polymer ◽

Surprising Result ◽

Cultivable Bacteria ◽

Planktonic Bacteria ◽

Loaded Material

In a previous paper, we proposed new silver nanoparticles (SNPs) based antibacterial coatings able to protect eukaryotic cells from SNPs related toxic effects, while preserving antibacterial efficiency. A SNPs containing n-heptylamine (HA) polymer matrix was deposited by plasma polymerization and coated by a second HA layer. In this paper, we elucidate the antibacterial action of these new coatings. We demonstrated that SNPs-loaded material can be covered by thin HA polymer layer without losing the antibacterial activity to planktonic bacteria living in the near surroundings of the material. SNPs-containing materials also revealed antibacterial effect on adhered bacteria. Adhered bacteria number was significantly reduced compared to pure HA plasma polymer and the physiology of the bacteria was affected. The number of adhered bacteria directly decreased with thickness of the second HA layer. Surprisingly, the quantity of cultivable bacteria harvested by transfer to nutritive agar decreased not only with the presence of SNPs, but also in relation to the covering HA layer thickness, that is, oppositely to the increase in adhered bacteria number. Two hypotheses are proposed for this surprising result (stronger attachment or weaker vitality), which raises the question of the diverse potential ways of action of SNPs entrapped in a polymer matrix.

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Silicon Nitride (Si3N4) Implants: The Future of Dental Implantology?

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-16-00146 ◽

2017 ◽

Vol 43 (3) ◽

pp. 240-244 ◽

Cited By ~ 14

Author(s):

Zahi Badran ◽

Xavier Struillou ◽

Francis J Hughes ◽

Assem Soueidan ◽

Alain Hoornaert ◽

...

Keyword(s):

Silicon Nitride ◽

Dental Implants ◽

Dental Implant ◽

Clinical Success ◽

Treatment Options ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

Future Research ◽

Success Rates ◽

Biological Performance

For decades titanium has been the preferred material for dental implant fabrication, with mechanical and biological performance resulting in high clinical success rates. These have been further enhanced by incremental development of surface modifications aimed at improving speed and degree of osseointegration and resulting in enhanced clinical treatment options and outcomes. However, increasing demand for metal-free dental restorations has also led to the development of ceramic-based dental implants, such as zirconia. In orthopedics, alternative biomaterials, such as polyetheretherketone or silicon nitride, have been used for implant applications. The latter is potentially of particular interest for oral use as it has been shown to have antibacterial properties. In this article we aim to shed light on this particular biomaterial as a future promising candidate for dental implantology applications, addressing basic specifications required for any dental implant material. In view of available preclinical data, silicon nitride seems to have the essential characteristics to be a candidate for dental implants material. This novel ceramic has a surface with potentially antimicrobial properties, and if this is confirmed in future research, it could be of great interest for oral use.

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