scholarly journals Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21889-21904 ◽  
Author(s):  
Lukasova Vera ◽  
Buzgo Matej ◽  
Vocetkova Karolina ◽  
Kubíková Tereza ◽  
Tonar Zbyněk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
3D Scaffolds ◽  
Centrifugal Spinning ◽  
Term Delivery

Bone regeneration is a long-term process requiring proper scaffolding and drug delivery systems.

BioMEMS Technologies for Regenerative Medicine

2008 ◽  
Vol 1139 ◽  
Author(s):  
Jeffrey T. Borenstein
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Organ Shortage ◽  
Engineered Tissues ◽  
Drug Concentrations

AbstractThe emergence of BioMEMS fabrication technologies such as soft lithography, micromolding and assembly of 3D structures, and biodegradable microfluidics, are already making significant contributions to the field of regenerative medicine. Over the past decade, BioMEMS have evolved from early silicon laboratory devices to polymer-based structures and even biodegradable constructs suitable for a range of ex vivo and in vivo applications. These systems are still in the early stages of development, but the long-term potential of the technology promises to enable breakthroughs in health care challenges ranging from the systemic toxicity of drugs to the organ shortage. Ex vivo systems for organ assist applications are emerging for the liver, kidney and lung, and the precision and scalability of BioMEMS fabrication techniques offer the promise of dramatic improvements in device performance and patient outcomes.Ultimately, the greatest benefit from BioMEMS technologies will be realized in applications for implantable devices and systems. Principal advantages include the extreme levels of achievable miniaturization, integration of multiple functions such as delivery, sensing and closed loop control, and the ability of precision microscale and nanoscale features to reproduce the cellular microenvironment to sustain long-term functionality of engineered tissues. Drug delivery systems based on BioMEMS technologies are enabling local, programmable control over drug concentrations and pharmacokinetics for a broad spectrum of conditions and target organs. BioMEMS fabrication methods are also being applied to the development of engineered tissues for applications such as wound healing, microvascular networks and bioartificial organs. Here we review recent progress in BioMEMS-based drug delivery systems, engineered tissue constructs and organ assist devices for a range of ex vivo and in vivo applications in regenerative medicine.

scholarly journals Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 70 ◽  
Author(s):  
Imke Rudnik-Jansen ◽  
Nina Woike ◽  
Suzanne de Jong ◽  
Sabine Versteeg ◽  
Marja Kik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Total Duration ◽  
Delivery Systems ◽  
Pain Behavior ◽  
Streptococcal Cell Wall ◽  
Arthritis Model ◽  
Acute Arthritis ◽  
Analgesic Effects

Episodes of inflammation and pain are predominant features of arthritic joint diseases. Drug delivery systems (DDS) could reduce inflammation and pain long-term without chances of infection upon multiple injections. To allow for long-term evaluation of DDS, we modified a previously published acute arthritis model by extending follow-up periods between flare-ups. Unilateral synovial inflammation of the knee was induced by intra-articular injection of streptococcal cell wall peptidoglycan polysaccharide (PGPS), and flare-ups were induced by intravenous PGPS injections every 4 weeks for a total duration of 84 days. In PGPS-reactivated animals, joint swelling, pain behavior, post mortem synovitis, and osteophyte formation were notable features. Hepatitis, splenitis and inflammation of non-primed joints were observed as systemic side effects. To test the applicability of the modified arthritis model for long-term testing of DDS, the duration of anti-inflammatory and analgesic effects of a corticosteroid released from two different polymer-based platforms was evaluated. The current modified arthritis model has good applicability for testing of DDS for a prolonged period of time. Furthermore, the novel autoregulatory polyesteramide (PEA) microsphere platform releasing triamcinolone acetonide (TAA) was benchmarked against poly lactic-co-glycolic acid (PLGA) and reduced joint swelling and pain behavior more potently compared to TAA-loaded PLGA microspheres.

scholarly journals Double-layered microsphere based dual growth factor delivery system for guided bone regeneration

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16503-16512 ◽  
Author(s):  
Chun Xu ◽  
Jia Xu ◽  
Lan Xiao ◽  
Zhihao Li ◽  
Yin Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Guided Bone Regeneration ◽  
Delivery Systems ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

Microsphere based drug delivery systems show great advantages for tissue engineering.

Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome

Pain Medicine ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 515-520 ◽  
Author(s):  
Eric Z Herring ◽  
Leonardo A Frizon ◽  
Olivia Hogue ◽  
Jay U Mejia ◽  
Richard Rosenquist ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Complex Regional Pain Syndrome ◽  
Drug Delivery Systems ◽  
Pain Syndrome ◽  
Delivery Systems ◽  
Long Term Outcomes ◽  
Intrathecal Drug Delivery

scholarly journals Sustained-release drug delivery systems for the treatment of glaucoma

2021 ◽  
Vol 14 (1) ◽  
pp. 148-159
Author(s):  
Natasha P. Kesav ◽  
◽  
Monica K. Ertel ◽  
Leonard K. Seibold ◽  
Malik Y. Kahook ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Patient Adherence ◽  
The United States ◽  
Delivery Systems ◽  
Release Drug ◽  
Systemic Side Effects

Glaucoma, a leading cause of irreversible blindness, affects more than 64 million people worldwide and is expected to grow in number due to the aging global population and enhanced methods of detection. Although topical therapies are often effective when used as prescribed, the drawbacks of current medical management methods include poor patient adherence, local and systemic side effects, and in some cases, limited therapeutic efficacy. Novel ocular drug delivery platforms promise to deliver differentiated drug formulations with targeted delivery leveraging patient-independent administration. Several platforms are in various stages of development with promising pre-clinical and clinical data. The Bimatoprost Sustained Release (SR) intracameral implant was approved in the United States in March of 2020, making it the first long-term injectable therapy available for the treatment of glaucoma. This review aims to provide an update on novel sustained release drug delivery systems that are available today as well as those that might be commercialized in coming years.

scholarly journals Drug Delivery Systems in Bone Regeneration and Implant Dentistry

10.5772/60003 ◽  
2015 ◽  
Author(s):  
Sukumaran Anil ◽  
Asala F. Al-Sulaimani ◽  
Ansar E. Beeran ◽  
Elna P. Chalisserry ◽  
Harikrishna P.R. Varma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Implant Dentistry

scholarly journals Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 95 ◽  
Author(s):  
Kaoru Aoki ◽  
Naoto Saito
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Drug Delivery Systems ◽  
Calcium Phosphates ◽  
Delivery Systems ◽  
Polymer Scaffolds ◽  
Synthetic Scaffold ◽  
And Performance ◽  
Potential Use

Regenerative medicine has been widely researched for the treatment of bone defects. In the field of bone regenerative medicine, signaling molecules and the use of scaffolds are of particular importance as drug delivery systems (DDS) or carriers for cell differentiation, and various materials have been explored for their potential use. Although calcium phosphates such as hydroxyapatite and tricalcium phosphate are clinically used as synthetic scaffold material for bone regeneration, biodegradable materials have attracted much attention in recent years for their clinical application as scaffolds due their ability to facilitate rapid localized absorption and replacement with autologous bone. In this review, we introduce the types, features, and performance characteristics of biodegradable polymer scaffolds in their role as DDS for bone regeneration therapy.

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