LA-ICP-MS and MALDI-MS image registration for correlating nanomaterial biodistributions and their biochemical effects

The Analyst ◽  
2021 ◽  
Author(s):  
Laura J. Castellanos-García ◽  
Kristen N. Sikora ◽  
Jeerapat Doungchawee ◽  
Richard Vachet
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Mass Spectrometry Imaging ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Inductively Coupled ◽  
Biochemical Effects ◽  
Ms Imaging ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) imaging and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) are complementary methods that measure distributions of elements and biomolecules in tissue...

Simultaneous measurement of Re–Os and S isotopic compositions of sulfur-bearing minerals using a Carius tube digestion-based N-TIMS and MC-ICP-MS approach

2018 ◽  
Vol 33 (6) ◽  
pp. 1057-1067 ◽  
Author(s):  
Shengling Sun ◽  
Jie Li ◽  
Le Zhang ◽  
Lu Yin ◽  
Jing Zhang
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Thermal Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Inductively Coupled ◽  
Isotopic Compositions ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Thermal Ionization Mass

This study reports an improved procedure for the simultaneous determination of Re–Os and S isotopic compositions of sulfur-bearing minerals using negative thermal ionization mass spectrometry (N-TIMS) and multicollector-inductively coupled plasma-mass spectrometry (MC-ICP-MS), respectively.

scholarly journals Assessing the age of the Late Cretaceous Danek Bonebed with U–Pb geochronology

2014 ◽  
Vol 51 (11) ◽  
pp. 982-986 ◽  
Author(s):  
Joshua H.F.L. Davies ◽  
Jörn-Frederik Wotzlaw ◽  
Alexander P. Wolfe ◽  
Larry M. Heaman
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Age Distribution ◽  
Ionization Mass ◽  
Accessory Zircon ◽  
Zircon Age ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Rich Material

An ash-rich volcaniclastic sandstone immediately underlying dinosaur-rich material from the Danek Bonebed in the Horseshoe Canyon Formation (HCF), Edmonton, Alberta, Canada, contains accessory zircon, which have been dated employing U–Pb geochronology. Both laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and chemical abrasion isotope dilution thermal ionization mass spectrometry (ID-TIMS) U–Pb analyses have been conducted. The zircon age distributions are complex with U–Pb dates ranging from Precambrian to Cretaceous. We consider the youngest ID-TIMS 206Pb/238U date of 71.923 ± 0.068 Ma as the maximum deposition age of the ash-rich sandstone, placing the overlying Danek bonebed in the early Maastrichtian. This age is compatible with the paleontological assemblage from the Danek Bonebed and the regional stratigraphy. The zircon age distribution also implies that the HCF had a complex provenance of the detritus with some Archean and Proterozoic zircons, a group of Mesozoic, and a large compliment of Cretaceous grains. The results highlight the importance of high precision geochronology in constraining the age of important fossil deposits such as the Danek Bonebed.

scholarly journals Precise Measurement of Tellurium Isotope Ratios in Terrestrial Standards Using a Multiple Collector Inductively Coupled Plasma Mass Spectrometry

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1956
Author(s):  
Rajamanickam Murugan ◽  
Tatsuo Aono ◽  
Sarata Kumar Sahoo
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Isotope Ratio ◽  
Thermal Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Ratio Measurement ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Thermal Ionization Mass

Precise tellurium (Te) isotope ratio measurement using mass spectrometry is a challenging task for many decades. In this paper, Te isotope ratio measurements using multi-collector inductively coupled plasma mass spectrometry (MC–ICP–MS) in terrestrial Te standards have been reported. Newly developed Faraday cup with 1012 Ω resistor is used to measure low abundance 120Te, whereas the 1011 Ω resistor is used to measure other Te isotopes. The relative standard deviation obtained for Te isotope ratio measurement by Faraday cups of 120Te/128Te [0.002907(05)], 122Te/128Te [0.079646(10)], 123Te/128Te [0.027850(07)], 125Te/128Te [0.221988(09)], 126Te/128Te [0.592202(20)], and 130Te/128Te [1.076277(30)] were 0.140%, 0.014%, 0.026%, 0.005%, 0.004%, and 0.004%, respectively. The measured isotope ratio results are compared with previous results obtained by thermal ionization mass spectrometry (TIMS), negative thermal ionization mass spectrometry (N–TIMS), and MC–ICP–MS, showing an improvement in the precision about one order of magnitude for 120Te/128Te ratio. The present study shows better precision for Te isotope ratios compared to earlier studies.

Reconstruction, analysis, and segmentation of LA-ICP-MS imaging data using Python for the identification of sub-organ regions in tissues

The Analyst ◽  
2020 ◽  
Vol 145 (10) ◽  
pp. 3705-3712
Author(s):  
Laura J. Castellanos-García ◽  
S. Gokhan Elci ◽  
Richard W. Vachet
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Biological Tissues ◽  
Imaging Data ◽  
Inductively Coupled ◽  
Ms Imaging ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Freely available software written in Python is described that can analyze and reconstruct laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging data, and enable the segmentation of metal distributions in biological tissues.

Stitching together the Ungava Orogen, northern Quebec: geochronological (TIMS and ICP–MS) and geochemical constraints on late magmatic events

1995 ◽  
Vol 32 (12) ◽  
pp. 2115-2127 ◽  
Author(s):  
J. M. Dunphy ◽  
J. N. Ludden ◽  
R. R. Parrish
Keyword(s):  
Mass Spectrometry ◽  
Continental Crust ◽  
Inductively Coupled Plasma ◽  
Ionization Mass ◽  
Inductively Coupled ◽  
High K ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
High Concentrations ◽  
Host Rocks

Late magmatic activity in the Ungava Orogen of northern Quebec is manifest as granitic dykes and small, rare plutons that crosscut all tectono-stratigraphic elements of the orogen. Conventional U–Pb geochronology (thermal ionization mass spectrometry (TIMS)) on one particularly important pluton that cuts all these domains (the Lac Duquet monzogranite) indicates its age of emplacement at 1742.2 ± 1.3 Ma. This undeformed and nonmetamorphosed pluton postdates the youngest structures in the orogen (D4 folds), thereby constraining the timing of the latest deformation to >1742 Ma. Laser ablation inductively coupled plasma–mass spectrometry (ICP–MS) on zircons from the same sample identified a large range in 207Pb/206Pb ages of inherited grains from 1.7 to 3.2 Ga, corresponding to the ages of the host rocks for the pluton. This high-K peraluminous monzogranite pluton contains moderate to high concentrations of large ion lithophile elements and fractionated and enriched light rare earth elements, similar in composition to the surrounding continental crust and to other crustally derived granites. Initial 87Sr/86Sr values of 0.7040–0.7051 and εNd ranging from −4.4 to −9.7 indicate incorporation of a significant amount of older material in the petrogenesis of the pluton. It is proposed that anatexis of the surrounding continental crust due to structural thickening during the waning stages of the Ungava orogeny resulted in the generation of the Lac Duquet pluton and was the source for its inherited zircons.

scholarly journals Sample loss in asymmetric flow field-flow fractionation coupled to inductively coupled plasma-mass spectrometry of silver nanoparticles

2015 ◽  
Vol 30 (10) ◽  
pp. 2214-2222 ◽  
Author(s):  
Carina A. Sötebier ◽  
Frank S. Bierkandt ◽  
Steffi Rades ◽  
Norbert Jakubowski ◽  
Ulrich Panne ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Silver Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Field Flow Fractionation ◽  
Asymmetric Flow ◽  
Qualitative And Quantitative ◽  
Inductively Coupled ◽  
Ms Imaging ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A systematic study on recovery rates and sample loss in AF4 including qualitative and quantitative LA-ICP-MS imaging of the membrane was performed.

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