Preparation of Antibacterial Nanofibers by Electrospinning Polyvinyl Alcohol Containing Luteolin Hydroxypropyl-β-Cyclodextrin Inclusion Complex

2022 ◽  
Author(s):  
Xiaoyan Wang ◽  
Xiaona Hu ◽  
Shiqing Li ◽  
Wenhui Shi ◽  
Shujing Li ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Inclusion Complex ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Water Solubility ◽  
Electrospinning Technique ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

The sustained-release antimicrobial nanofibers (PVA-Lut-IC-NF) were prepared by incorporating luteolin-hydroxypropyl-β-cyclodextrin inclusion complex (Lut-IC) into polyvinyl alcohol (PVA) via electrospinning technique. PVA-Lut-IC-NF has shown the excellent water-solubility and thermal stability. The...

scholarly journals Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex

RSC Advances ◽  
2019 ◽  
Vol 9 (45) ◽  
pp. 26109-26115 ◽  
Author(s):  
Shuang Gao ◽  
Chao Bie ◽  
Qiuyu Ji ◽  
Haiyang Ling ◽  
Chunyan Li ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Inclusion Complex ◽  
Water Solubility ◽  
Herbicidal Activity ◽  
Beta Cyclodextrin ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Hydroxypropyl Beta Cyclodextrin

Cyanazine/HPβCD inclusion complex was prepared to improve water solubility and thermal stability and herbicidal activity of cyanazine.

scholarly journals Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Ye Zhang
Keyword(s):  
Inclusion Complex ◽  
Sustained Release ◽  
Clinical Application ◽  
Intranasal Administration ◽  
Fickian Diffusion ◽  
Antidepressant Effect ◽  
Control Group ◽  
Thermosensitive Gel ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Poor solubility and bioavailability are limiting factors for the clinical application of curcumin. This study seeks to develop poloxamer/chitosan thermosensitive gel containing curcumin-cyclodextrin inclusion complex with enhanced brain bioavailability and antidepressant effect. The optimized gel had shorter gelation time and produced sustained release in vitro characterized with non-Fickian diffusion. Pharmacokinetics of gel were evaluated using male Sprague-Dawley rats receiving 240 μg/kg of curcumin and curcumin-cyclodextrin inclusion complex through intranasal administration, compared against a control group receiving intravenous curcumin (240 μg/kg). The intranasal administration of gel provided sustained release by maintaining plasma concentrations of curcumin above 21.27 ± 3.26 ng/mL for up to 8 h. Compared to intranasal administration of the inclusion complex, AUC0–8 h of curcumin from thermoreversible gel in plasma and hippocampus was increased 1.62- and 1.28-fold, respectively. The gel exhibited superior antidepressant activity in mice. The findings reported here suggested that the clinical application of curcumin can be better exploited through an intranasal administration of the thermosensitive gel.

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