Tandem Molecular Self-assembly for Selective Lung Cancer Therapy with Two Orders of Magnitude Increase in Efficiency

Nanoscale ◽  
2021 ◽  
Author(s):  
Debin Zheng ◽  
Jingfei Liu ◽  
Yinghao Ding ◽  
Limin Xie ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Self Assembly ◽  
Therapeutic Efficacy ◽  
Self Assembling ◽  
Lung Cancer Therapy ◽  
Magnitude Increase

In situ self-assembling of prodrug molecules into nanomedicine can elevate the therapeutic efficacy of anticancer medications by enhancing the targeting and enrichment of anticancer drugs at tumor sites. However, the...

scholarly journals Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Luo ◽  
Yujuan Gao ◽  
Zhongyu Duan ◽  
Yu Yi ◽  
Hao Wang
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Recent Progress ◽  
Assembly Systems ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
Self Assembling ◽  
Stimuli Response

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

MicroRNAs as Therapeutic Targets for Anticancer Drugs in Lung Cancer Therapy

2020 ◽  
Vol 20 (16) ◽  
pp. 1883-1894
Author(s):  
Yuan-Rong Liu ◽  
Ping-Yu Wang ◽  
Ning Xie ◽  
Shu-Yang Xie
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Messenger Rnas ◽  
Antitumor Activities ◽  
Lung Cancers ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Lung Cancer Therapy ◽  
Therapeutic Mechanisms

MicroRNAs (miRNAs) are short, non-coding RNA molecules that regulate gene expression by translational repression or deregulation of messenger RNAs. Accumulating evidence suggests that miRNAs play various roles in the development and progression of lung cancers. Although their precise roles in targeted cancer therapy are currently unclear, miRNAs have been shown to affect the sensitivity of tumors to anticancer drugs. A large number of recent studies have demonstrated that some anticancer drugs exerted antitumor activities by affecting the expression of miRNAs and their targeted genes. These studies have elucidated the specific biological mechanism of drugs in tumor suppression, which provides a new idea or basis for their clinical application. In this review, we summarized the therapeutic mechanisms of drugs in lung cancer therapy through their effects on miRNAs and their targeted genes, which highlights the roles of miRNAs as targets in lung cancer therapy.

Multicompartmental lipid–protein nanohybrids for combined tretinoin/herbal lung cancer therapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (18) ◽  
pp. 2461-2479
Author(s):  
Nayra M Kamel ◽  
Maged W Helmy ◽  
Magda W Samaha ◽  
Doaa Ragab ◽  
Ahmed O Elzoghby
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Ion Pair ◽  
Pair Formation ◽  
Caspase Activation ◽  
Lung Cancer Therapy ◽  
Enhanced Stability

Aim: Multicompartmental lipid–protein nanohybrids (MLPNs) were developed for combined delivery of the anticancer drugs tretinoin (TRE) and genistein (GEN) as synergistic therapy of lung cancer. Materials & methods: The GEN-loaded lipid core was first prepared and then coated with TRE-loaded zein shell via nanoprecipitation. Results: TRE/GEN-MLPNs demonstrated a size of 154.5 nm. In situ ion pair formation between anionic TRE and the cationic stearyl amine improved the drug encapsulation with enhanced stability of MLPNs. TRE/GEN-coloaded MLPNs were more cytotoxic against A549 cancer cells compared with combined free GEN/TRE. In vivo, lung cancer bearing mice treated with TRE/GEN-MLPNs displayed higher apoptotic caspase activation compared with mice-treated free combined GEN/TRE. Conclusion: TRE/GEN-MLPNs might serve as a promising parenteral nanovehicles for lung cancer therapy.

Self-Assembly Cascade Reaction Platform for CD44 Positive Lung Cancer Therapy

2021 ◽  
Vol 17 (12) ◽  
pp. 2374-2381
Author(s):  
Haitao Miao ◽  
Xiaoxiao Zhu ◽  
Fei Yuan ◽  
Qing Su ◽  
Pei Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Tumor Tissue ◽  
A549 Cells ◽  
Cascade Reaction ◽  
Peroxidase Mimic ◽  
Lung Cancers ◽  
Prussian Blue Nanoparticles ◽  
Lung Cancer Therapy

Lung cancer, as one of the most fatal cancers around the world, is responsible for the death of millions every year. Among various types of lung cancers, the ones overexpressing CD44 is usually associated higher cell proliferation with poorer prognosis. Therefore, finding a way to effectively treat CD44 positive lung cancer is urgently needed. Here in this study, negatively charged ultrasmall prussian blue nanoparticles (UPBNPs) was firstly synthesized and adsorbed to polyethyleneimine (PEI) together with glucose oxidase (Gox). Afterwards, the PEI was further complexed with hyaluronic acid (HA) to give a cascade reaction platform (HP/UPB-Gox) for CD44 positive lung cancer therapy. The HP/UPB-Gox with HA shell was able to positively target CD44 overexpressed A549 cells. Upon arriving at the tumor tissue, the Gox catalyzed the glucose of tumor to create H2O2, which further served as the substrate of UPBNPs, a peroxidase mimic, to finally give highly toxic hydroxyl radical (OH) for cancer therapy. Therefore, the cascade reaction formed between UPBNPs and Gox was expected to realize effective treatment on CD44 overexpressed lung cancer.

Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer

2021 ◽  
Author(s):  
Mei Jiang ◽  
Yuchen Lin ◽  
Xiaocui Fang ◽  
Mingpeng Liu ◽  
Lilusi Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Delivery System ◽  
Gold Nanoclusters ◽  
Cationic Peptide ◽  
Gold Nanocluster ◽  
Lung Cancer Therapy ◽  
Anti Tumor Activity

A novel delivery system for cisplatin based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide was constructed. The constructed cisplatin@GC-pKs showed much enhanced anti-tumor activity for lung cancer therapy.

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