Study of the Interaction of Folic Acid-modified Gold Nanorods and Fibrinogen through Microfluidics: Implications on Protein Adsorption, Incorporation and Viability of Cancer Cells

Nanoscale ◽  
2021 ◽  
Author(s):  
Nacaroha Orellana ◽  
Sujey Palma-Florez ◽  
Estefania Torres ◽  
Maria Luisa Cordero ◽  
Valentina Vio ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Protein Adsorption ◽  
Gold Nanorods ◽  
Potential Applications

Gold nanoparticles (GNPs) are an attractive nanomaterial for potential applications in therapy and diagnostic due to their capability to direct toward specific sites in the organism. However, when exposed to...

Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells

2007 ◽  
Vol 3 (3) ◽  
pp. 224-238 ◽  
Author(s):  
Resham Bhattacharya ◽  
Chitta Ranjan Patra ◽  
Alexis Earl ◽  
Shanfeng Wang ◽  
Aaron Katarya ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Cancer Cells ◽  
Noncovalent Interaction

The Role of Adhesion in Gold Nanoparticles for Cancer Detection and Treatment

2015 ◽  
Vol 1132 ◽  
pp. 72-86
Author(s):  
Y. Oni ◽  
J.D. Obayemi ◽  
K. Kao ◽  
S. Dozie-Nwachukwu ◽  
S. Odusanya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Detection ◽  
Breast Cancer Cells ◽  
Au Nanoparticle ◽  
Adhesion Forces ◽  
Force Microscopy ◽  
Nanoparticle Clusters ◽  
Potential Applications

This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.

Integrin Targeted Gold Nanoparticles Potentiate Cancer Radiation Sensitivity: Synthesizing and modifying gold nanorods to target cancer cells.

2016 ◽  
Vol 10 (1) ◽  
pp. 4-15 ◽  
Author(s):  
I-Chun Yeh ◽  
Pei-Wen Wang ◽  
Hsin-Yi Liu ◽  
Ping-Ching Wu ◽  
Jenn-Ren Hsiao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Radiation Sensitivity ◽  
Target Cancer

Folic acid-modified methotrexate-conjugated gold nanoparticles as nano-sized trojans for drug delivery to folate receptor-positive cancer cells

2020 ◽  
Vol 31 (35) ◽  
pp. 355101
Author(s):  
Oğuz Yücel ◽  
Aslıhan Şengelen ◽  
Serkan Emik ◽  
Evren Önay-Uçar ◽  
Nazlı Arda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Folate Receptor

Fluorescent small Au nanodots prepared from large Ag nanoparticles for targeting and imaging cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 52088-52094 ◽  
Author(s):  
Yuanqing Sun ◽  
Dandan Wang ◽  
Lin Xu ◽  
Tianxin Zhao ◽  
Chuanxi Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Ag Nanoparticles ◽  
Targeted Imaging ◽  
Potential Applications ◽  
Au Nanodots

The fluorescent gold nanodots are conjugated with folic acid, which provides them with potential applications in targeted imaging of cancer cells.

scholarly journals Use in vitro of Gold Nanoparticles Functionalized with Folic Acid as a Photothermal Agent on Treatment of HeLa Cells

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Linda Bertel Garay ◽  
Fernando Martínez Ortega ◽  
Stelia Carolina Méndez-Sanchez
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
Molar Ratio ◽  
Functionalized Gold Nanoparticles ◽  
Dose Dependent

<p>Folic acid (FA) is used as a recognition molecule to achieve selective internalization in cancer cells. Here functionalized gold nanoparticles with folic acid (AuNP-FA) are proposed as suitable therapeutic agents for cervix cancer cells by photothermal damage. The functionalized gold nanoparticles with folic acid were synthesized by mixing hydrogen tetrachloroaurate with folic acid in a molar ratio of 0.56/1 under radiation of mercury lamp (λ<sub>max</sub>=254 nm). HeLa cells were incubated with AuNP-FA during 48 h, then were irradiated and the cytotoxicity was analyzed 12 h after irradiation. The AuNP-FA were dose-dependent cytotoxic under irradiation and not cytotoxic in the absence of radiation. The viability of cancer cells treated with functionalized and non-functionalized gold nanoparticles (AuNPs), with and without near infrared light at 808 nm, was measured by MTT assays. This work provides useful guidance toward the synthesis of biocompatible nanomaterials for biological applications.</p>

Conjugating folic acid to gold nanoparticles through glutathione for targeting and detecting cancer cells

2010 ◽  
Vol 18 (15) ◽  
pp. 5528-5534 ◽  
Author(s):  
Zhaowu Zhang ◽  
Jing Jia ◽  
Youqun Lai ◽  
Yanyan Ma ◽  
Jian Weng ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells
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