Polypyrrole Based Nanotheranostic Agent for MRI Guided Photothermal-Chemodynamic Synergistic Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Bangyi Zhou ◽  
Chenhui Yin ◽  
Qiang Feng ◽  
Yiting Wu ◽  
Xiaoyu Pan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Polypyrrole Nanoparticles ◽  
Good Biocompatibility ◽  
Mri Guided

Polypyrrole nanoparticles (PPy) have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we reported bovine serum albumin (BSA) stabilized...

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

Microenvironment Responsive DNA-conjugated Albumin Nanocarriers for Targeting Therapy

2021 ◽  
Author(s):  
Jiayu Yu ◽  
Jianing Zhang ◽  
Jing Jin ◽  
Wei Jiang
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Efficient Treatment ◽  
Targeting Therapy

Drug delivery with accurate targeting and efficient treatment has become an essential strategy for cancer therapy. Two nanocarriers based on bovine serum albumin (BSA) and DNA were synthesized by click...

Self-healing of thermally-induced, biocompatible and biodegradable protein hydrogel

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56183-56192 ◽  
Author(s):  
Jun Chen ◽  
Xiaoyu Ma ◽  
Qiuchen Dong ◽  
Donghui Song ◽  
Derek Hargrove ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Self Healing ◽  
Thermally Induced ◽  
External Heating ◽  
Good Biocompatibility ◽  
Recovery Performance

Almost 100% self-healing extent recovery performance was observed in thermal-induced bovine serum albumin hydrogel with external heating. Good biocompatibility and biodegradability of this materials were also demonstrated.

Improvement of an artificial test substrate technique for evaluation of em immunocytochemical labeling

1987 ◽  
Vol 45 ◽  
pp. 762-763
Author(s):  
G. D. Gagne ◽  
M. F. Miller
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Artificial Substrate ◽  
Chemical Fixation ◽  
As If

We recently described an artificial substrate system which could be used to optimize labeling parameters in EM immunocytochemistry (ICC). The system utilizes blocks of glutaraldehyde polymerized bovine serum albumin (BSA) into which an antigen is incorporated by a soaking procedure. The resulting antigen impregnated blocks can then be fixed and embedded as if they are pieces of tissue and the effects of fixation, embedding and other parameters on the ability of incorporated antigen to be immunocyto-chemically labeled can then be assessed. In developing this system further, we discovered that the BSA substrate can also be dried and then sectioned for immunolabeling with or without prior chemical fixation and without exposing the antigen to embedding reagents. The effects of fixation and embedding protocols can thus be evaluated separately.

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